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Boronic Acid Functionalized Nanosilica for Binding Guest Molecules

Xue, Xiaoting LU ; Gong, Haiyue LU ; Zheng, Hongwei LU and Ye, Lei LU orcid (2021) In ACS Applied Nano Materials 4(3). p.2866-2875
Abstract

Dendritic fibrous nanosilica (DFNS) has very high surface area and well-defined nanochannels; therefore, it is very useful as supporting material for numerous applications including catalysis, sensing, and bioseparation. Due to the highly restricted space, addition of molecular ligands to DFNS is very challenging. This work studies how ligand conjugation in nanoscale pores in DFNS can be achieved through copper-catalyzed click reaction, using an optional, in situ synthesized, temperature-responsive polymer intermediate. A clickable boronic acid is used as a model to investigate the ligand immobilization and the molecular binding characteristics of the functionalized DFNS. The morphology, composition, nanoscale pores, and specific... (More)

Dendritic fibrous nanosilica (DFNS) has very high surface area and well-defined nanochannels; therefore, it is very useful as supporting material for numerous applications including catalysis, sensing, and bioseparation. Due to the highly restricted space, addition of molecular ligands to DFNS is very challenging. This work studies how ligand conjugation in nanoscale pores in DFNS can be achieved through copper-catalyzed click reaction, using an optional, in situ synthesized, temperature-responsive polymer intermediate. A clickable boronic acid is used as a model to investigate the ligand immobilization and the molecular binding characteristics of the functionalized DFNS. The morphology, composition, nanoscale pores, and specific surface area of the boronic acid functionalized nanosilica were characterized by electron microscopy, thermogravimetric and elemental analysis, Fourier transform infrared spectroscopy, and nitrogen adsorption-desorption measurements. The numbers of boronic acid molecules on the modified DFNS with and without the polymer were determined to be 0.08 and 0.68 mmol of ligand/g of DFNS, respectively. We also studied the binding of small cis-diol molecules in the nanoscale pores of DFNS. The boronic acid modified DFNS with the polymer intermediate exhibits higher binding capacity for Alizarin Red S and nicotinamide adenine dinucleotide than the polymer-free DFNS. The two types of boronic acid modified DFNS can bind small cis-diol molecules in the presence of large glycoproteins, due in large part to the effect of size exclusion provided by the nanochannels in the DFNS.

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author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Alizarin Red S, boronic acid, copolymer brush, dendritic fibrous nanosilica, nicotinamide adenine dinucleotide, size exclusion
in
ACS Applied Nano Materials
volume
4
issue
3
pages
2866 - 2875
publisher
The American Chemical Society (ACS)
external identifiers
  • pmid:33842857
  • scopus:85102463798
ISSN
2574-0970
DOI
10.1021/acsanm.1c00005
language
English
LU publication?
yes
id
5e039ca7-3dec-4071-9f95-25a91cf2b053
date added to LUP
2021-03-29 08:17:20
date last changed
2024-07-13 11:03:45
@article{5e039ca7-3dec-4071-9f95-25a91cf2b053,
  abstract     = {{<p>Dendritic fibrous nanosilica (DFNS) has very high surface area and well-defined nanochannels; therefore, it is very useful as supporting material for numerous applications including catalysis, sensing, and bioseparation. Due to the highly restricted space, addition of molecular ligands to DFNS is very challenging. This work studies how ligand conjugation in nanoscale pores in DFNS can be achieved through copper-catalyzed click reaction, using an optional, in situ synthesized, temperature-responsive polymer intermediate. A clickable boronic acid is used as a model to investigate the ligand immobilization and the molecular binding characteristics of the functionalized DFNS. The morphology, composition, nanoscale pores, and specific surface area of the boronic acid functionalized nanosilica were characterized by electron microscopy, thermogravimetric and elemental analysis, Fourier transform infrared spectroscopy, and nitrogen adsorption-desorption measurements. The numbers of boronic acid molecules on the modified DFNS with and without the polymer were determined to be 0.08 and 0.68 mmol of ligand/g of DFNS, respectively. We also studied the binding of small cis-diol molecules in the nanoscale pores of DFNS. The boronic acid modified DFNS with the polymer intermediate exhibits higher binding capacity for Alizarin Red S and nicotinamide adenine dinucleotide than the polymer-free DFNS. The two types of boronic acid modified DFNS can bind small cis-diol molecules in the presence of large glycoproteins, due in large part to the effect of size exclusion provided by the nanochannels in the DFNS. </p>}},
  author       = {{Xue, Xiaoting and Gong, Haiyue and Zheng, Hongwei and Ye, Lei}},
  issn         = {{2574-0970}},
  keywords     = {{Alizarin Red S; boronic acid; copolymer brush; dendritic fibrous nanosilica; nicotinamide adenine dinucleotide; size exclusion}},
  language     = {{eng}},
  number       = {{3}},
  pages        = {{2866--2875}},
  publisher    = {{The American Chemical Society (ACS)}},
  series       = {{ACS Applied Nano Materials}},
  title        = {{Boronic Acid Functionalized Nanosilica for Binding Guest Molecules}},
  url          = {{http://dx.doi.org/10.1021/acsanm.1c00005}},
  doi          = {{10.1021/acsanm.1c00005}},
  volume       = {{4}},
  year         = {{2021}},
}