Point of no return for improvement of cartilage quality indicated by dGEMRIC before and after weight loss in patients with knee osteoarthritis : a cohort study
(2018) In Acta Radiologica 59(3). p.336-340- Abstract
Background: It has been demonstrated that weight loss improves symptoms in obese subjects with knee osteoarthritis (KOA). A parallel change in cartilage morphology remains to be demonstrated. Purpose: To demonstrate a parallel change in cartilage morphology. Material and Methods: Obese patients with KOA were examined before and after weight loss over 16 weeks. Target knee joints were radiographically assessed by the Kellgren/Lawrence grading (KLG) system. Patients with KLG-1 and 2 changes in the lateral compartment were included. Delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) was performed using intra-articular contrast. Results: Nine patients with lateral KLG-1 and ten patients with lateral KLG-2 were studied. There were no... (More)
Background: It has been demonstrated that weight loss improves symptoms in obese subjects with knee osteoarthritis (KOA). A parallel change in cartilage morphology remains to be demonstrated. Purpose: To demonstrate a parallel change in cartilage morphology. Material and Methods: Obese patients with KOA were examined before and after weight loss over 16 weeks. Target knee joints were radiographically assessed by the Kellgren/Lawrence grading (KLG) system. Patients with KLG-1 and 2 changes in the lateral compartment were included. Delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) was performed using intra-articular contrast. Results: Nine patients with lateral KLG-1 and ten patients with lateral KLG-2 were studied. There were no group differences regarding the lateral compartment baseline dGEMRIC T1 values: median = 497 ms (KLG-1) and 533 ms (KLG-2) (P = 0.12), or regarding reduction in body mass index (BMI) after 16 weeks: 12.8% versus 11.4% (P = 0.74). In the KLG-1 group, several cases of increased dGEMRIC T1 values were seen and median value decreased significantly less than in KLG-2 group (15 ms versus 41 ms, P = 0.03) after weight loss. Conclusion: Improvement of cartilage quality, assessed with dGEMRIC, after weight loss might be possible in early stage KOA (KLG-1), but not in later stage KOA (KLG-2). The results may suggest a point of no return for improvement of cartilage quality that should be tested in larger trials.
(Less)
- author
- Hangaard, Stine ; Gudbergsen, Henrik ; Skougaard, Marie ; Bliddal, Henning ; Nybing, Janus D. ; Tiderius, Carl Johan LU and Boesen, Mikael
- organization
- publishing date
- 2018-03-01
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- cartilage, dGEMRIC, Knee osteoarthritis (KOA), magnetic resonance imaging (MRI), weight loss
- in
- Acta Radiologica
- volume
- 59
- issue
- 3
- pages
- 5 pages
- publisher
- SAGE Publications
- external identifiers
-
- pmid:28696168
- scopus:85041723263
- ISSN
- 0284-1851
- DOI
- 10.1177/0284185117720857
- language
- English
- LU publication?
- yes
- id
- 5f727f8f-a2e7-47b7-a48c-ccb245ffbb15
- date added to LUP
- 2018-03-01 09:38:32
- date last changed
- 2024-06-10 08:36:03
@article{5f727f8f-a2e7-47b7-a48c-ccb245ffbb15, abstract = {{<p>Background: It has been demonstrated that weight loss improves symptoms in obese subjects with knee osteoarthritis (KOA). A parallel change in cartilage morphology remains to be demonstrated. Purpose: To demonstrate a parallel change in cartilage morphology. Material and Methods: Obese patients with KOA were examined before and after weight loss over 16 weeks. Target knee joints were radiographically assessed by the Kellgren/Lawrence grading (KLG) system. Patients with KLG-1 and 2 changes in the lateral compartment were included. Delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) was performed using intra-articular contrast. Results: Nine patients with lateral KLG-1 and ten patients with lateral KLG-2 were studied. There were no group differences regarding the lateral compartment baseline dGEMRIC T1 values: median = 497 ms (KLG-1) and 533 ms (KLG-2) (P = 0.12), or regarding reduction in body mass index (BMI) after 16 weeks: 12.8% versus 11.4% (P = 0.74). In the KLG-1 group, several cases of increased dGEMRIC T1 values were seen and median value decreased significantly less than in KLG-2 group (15 ms versus 41 ms, P = 0.03) after weight loss. Conclusion: Improvement of cartilage quality, assessed with dGEMRIC, after weight loss might be possible in early stage KOA (KLG-1), but not in later stage KOA (KLG-2). The results may suggest a point of no return for improvement of cartilage quality that should be tested in larger trials.</p>}}, author = {{Hangaard, Stine and Gudbergsen, Henrik and Skougaard, Marie and Bliddal, Henning and Nybing, Janus D. and Tiderius, Carl Johan and Boesen, Mikael}}, issn = {{0284-1851}}, keywords = {{cartilage; dGEMRIC; Knee osteoarthritis (KOA); magnetic resonance imaging (MRI); weight loss}}, language = {{eng}}, month = {{03}}, number = {{3}}, pages = {{336--340}}, publisher = {{SAGE Publications}}, series = {{Acta Radiologica}}, title = {{Point of no return for improvement of cartilage quality indicated by dGEMRIC before and after weight loss in patients with knee osteoarthritis : a cohort study}}, url = {{http://dx.doi.org/10.1177/0284185117720857}}, doi = {{10.1177/0284185117720857}}, volume = {{59}}, year = {{2018}}, }