Soluble CD163 was linked to galectin-3, diabetic retinopathy and antidepressants in type 1 diabetes
Melin, Eva O LU ; Dereke, Jonatan LU
; Thunander, Maria
LU
and Hillman, Magnus
LU
(2018)
In Endocrine Connections
7(12).
p.1343-1353
- Abstract
OBJECTIVE: Depression has been associated with diabetic retinopathy and increased plasma levels of galectin-3, a lectin expressed in activated macrophages. Increased levels of sCD163, the soluble form of a macrophage expressed scavenger receptor involved in several inflammatory processes, have been demonstrated in the vitreous of the eye in type 1 diabetes (T1D) patients with severe diabetic retinopathy. The aim was to explore whether circulating sCD163 was associated with diabetic retinopathy, depression, and/or galectin-3 in T1D patients, controlling for gender, metabolic factors, other diabetes complications, life style, and medication.
DESIGN: Cross sectional.
METHODS: Two hundred and eighty-seven T1D patients, men 56%,... (More)
OBJECTIVE: Depression has been associated with diabetic retinopathy and increased plasma levels of galectin-3, a lectin expressed in activated macrophages. Increased levels of sCD163, the soluble form of a macrophage expressed scavenger receptor involved in several inflammatory processes, have been demonstrated in the vitreous of the eye in type 1 diabetes (T1D) patients with severe diabetic retinopathy. The aim was to explore whether circulating sCD163 was associated with diabetic retinopathy, depression, and/or galectin-3 in T1D patients, controlling for gender, metabolic factors, other diabetes complications, life style, and medication.
DESIGN: Cross sectional.
METHODS: Two hundred and eighty-seven T1D patients, men 56%, age 18-59 years, diabetes duration ≥1 year, were consecutively recruited from one specialist diabetes clinic. Depression was assessed by Hospital Anxiety and Depression Scale-depression subscale. Blood samples, anthropometrics and blood pressure were collected, supplemented with data from electronic medical records and the Swedish National Diabetes Registry. High plasma sCD163 was defined as ≥ 0.575 mg/l (corresponding to the 80th percentile) and high plasma galectin-3 as ≥4.659 µg/l (corresponding to the 95th percentile).
RESULTS: The prevalence of depression was 10%, antidepressant medication 8%, diabetic retinopathy 72%, high sCD163 20%, and high galectin-3 5%. High galectin-3 (AOR 9.7), antidepressants (AOR 3.8), diabetic retinopathy (AOR 2.4), and systolic blood pressure (per mm Hg) (AOR 1.03) were associated with high sCD163.
CONCLUSIONS: This is the first study to show that circulating sCD163 was independently associated with galectin-3, the use of antidepressants, and diabetic retinopathy, in patients with T1D. Depression was not associated with sCD163.
(Less)
- author
- Melin, Eva O
LU
; Dereke, Jonatan
LU
; Thunander, Maria
LU
and Hillman, Magnus
LU
- organization
- publishing date
- 2018
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Endocrine Connections
- volume
- 7
- issue
- 12
- pages
- 1343 - 1353
- publisher
- BioScientifica
- external identifiers
-
- pmid:30400063
- scopus:85065089633
- ISSN
- 2049-3614
- DOI
- 10.1530/EC-18-0336
- language
- English
- LU publication?
- yes
- id
- 5f9abfca-f7ba-4988-b9f6-b852d6746566
- date added to LUP
- 2019-01-10 14:43:59
- date last changed
- 2024-04-15 20:35:26
@article{5f9abfca-f7ba-4988-b9f6-b852d6746566,
abstract = {{<p>OBJECTIVE: Depression has been associated with diabetic retinopathy and increased plasma levels of galectin-3, a lectin expressed in activated macrophages. Increased levels of sCD163, the soluble form of a macrophage expressed scavenger receptor involved in several inflammatory processes, have been demonstrated in the vitreous of the eye in type 1 diabetes (T1D) patients with severe diabetic retinopathy. The aim was to explore whether circulating sCD163 was associated with diabetic retinopathy, depression, and/or galectin-3 in T1D patients, controlling for gender, metabolic factors, other diabetes complications, life style, and medication.</p><p>DESIGN: Cross sectional.</p><p>METHODS: Two hundred and eighty-seven T1D patients, men 56%, age 18-59 years, diabetes duration ≥1 year, were consecutively recruited from one specialist diabetes clinic. Depression was assessed by Hospital Anxiety and Depression Scale-depression subscale. Blood samples, anthropometrics and blood pressure were collected, supplemented with data from electronic medical records and the Swedish National Diabetes Registry. High plasma sCD163 was defined as ≥ 0.575 mg/l (corresponding to the 80th percentile) and high plasma galectin-3 as ≥4.659 µg/l (corresponding to the 95th percentile).</p><p>RESULTS: The prevalence of depression was 10%, antidepressant medication 8%, diabetic retinopathy 72%, high sCD163 20%, and high galectin-3 5%. High galectin-3 (AOR 9.7), antidepressants (AOR 3.8), diabetic retinopathy (AOR 2.4), and systolic blood pressure (per mm Hg) (AOR 1.03) were associated with high sCD163.</p><p>CONCLUSIONS: This is the first study to show that circulating sCD163 was independently associated with galectin-3, the use of antidepressants, and diabetic retinopathy, in patients with T1D. Depression was not associated with sCD163.</p>}},
author = {{Melin, Eva O and Dereke, Jonatan and Thunander, Maria and Hillman, Magnus}},
issn = {{2049-3614}},
language = {{eng}},
number = {{12}},
pages = {{1343--1353}},
publisher = {{BioScientifica}},
series = {{Endocrine Connections}},
title = {{Soluble CD163 was linked to galectin-3, diabetic retinopathy and antidepressants in type 1 diabetes}},
url = {{http://dx.doi.org/10.1530/EC-18-0336}},
doi = {{10.1530/EC-18-0336}},
volume = {{7}},
year = {{2018}},
}