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The role of glia in Parkinson's disease : Emerging concepts and therapeutic applications

Kuter, Katarzyna Z. LU ; Cenci, M. Angela LU orcid and Carta, Anna R. (2020) In Progress in Brain Research 252. p.131-168
Abstract

Originally believed to primarily affect neurons, Parkinson's disease (PD) has recently been recognized to also affect the functions and integrity of microglia and astroglia, two cell categories of fundamental importance to brain tissue homeostasis, defense, and repair. Both a loss of glial supportive-defensive functions and a toxic gain of glial functions are implicated in the neurodegenerative process. Moreover, the chronic treatment with L-DOPA may cause maladaptive glial plasticity favoring a development of therapy complications. This chapter focuses on the pathophysiology of PD from a glial point of view, presenting this rapidly growing field from the first discoveries made to the most recent developments. We report and compare... (More)

Originally believed to primarily affect neurons, Parkinson's disease (PD) has recently been recognized to also affect the functions and integrity of microglia and astroglia, two cell categories of fundamental importance to brain tissue homeostasis, defense, and repair. Both a loss of glial supportive-defensive functions and a toxic gain of glial functions are implicated in the neurodegenerative process. Moreover, the chronic treatment with L-DOPA may cause maladaptive glial plasticity favoring a development of therapy complications. This chapter focuses on the pathophysiology of PD from a glial point of view, presenting this rapidly growing field from the first discoveries made to the most recent developments. We report and compare histopathological and molecular findings from experimental models of PD and human studies. We moreover discuss the important role played by astrocytes in compensatory adaptations taking place during presymptomatic disease stages. We finally describe examples of potential therapeutic applications stemming from an increased understanding of the important roles of glia in PD.

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Please use this url to cite or link to this publication:
author
; and
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
keywords
Astrocytes, Compensation, Dyskinesia, Energy metabolism, Grafting, Inflammation, Levodopa, Microglia, Pharmacology, α-Synuclein
host publication
Recent Advances in Parkinson's Disease
series title
Progress in Brain Research
editor
Björklund, Anders and Cenci, M. Angela
volume
252
pages
38 pages
publisher
Elsevier Science Publishers B.V.
external identifiers
  • scopus:85081964251
  • pmid:32247363
ISSN
1875-7855
0079-6123
ISBN
9780444642608
DOI
10.1016/bs.pbr.2020.02.004
language
English
LU publication?
yes
id
5fa022fe-4e04-4b02-9fb8-40eaec43982d
date added to LUP
2020-04-09 08:05:45
date last changed
2024-06-13 14:20:44
@inbook{5fa022fe-4e04-4b02-9fb8-40eaec43982d,
  abstract     = {{<p>Originally believed to primarily affect neurons, Parkinson's disease (PD) has recently been recognized to also affect the functions and integrity of microglia and astroglia, two cell categories of fundamental importance to brain tissue homeostasis, defense, and repair. Both a loss of glial supportive-defensive functions and a toxic gain of glial functions are implicated in the neurodegenerative process. Moreover, the chronic treatment with L-DOPA may cause maladaptive glial plasticity favoring a development of therapy complications. This chapter focuses on the pathophysiology of PD from a glial point of view, presenting this rapidly growing field from the first discoveries made to the most recent developments. We report and compare histopathological and molecular findings from experimental models of PD and human studies. We moreover discuss the important role played by astrocytes in compensatory adaptations taking place during presymptomatic disease stages. We finally describe examples of potential therapeutic applications stemming from an increased understanding of the important roles of glia in PD.</p>}},
  author       = {{Kuter, Katarzyna Z. and Cenci, M. Angela and Carta, Anna R.}},
  booktitle    = {{Recent Advances in Parkinson's Disease}},
  editor       = {{Björklund, Anders and Cenci, M. Angela}},
  isbn         = {{9780444642608}},
  issn         = {{1875-7855}},
  keywords     = {{Astrocytes; Compensation; Dyskinesia; Energy metabolism; Grafting; Inflammation; Levodopa; Microglia; Pharmacology; α-Synuclein}},
  language     = {{eng}},
  pages        = {{131--168}},
  publisher    = {{Elsevier Science Publishers B.V.}},
  series       = {{Progress in Brain Research}},
  title        = {{The role of glia in Parkinson's disease : Emerging concepts and therapeutic applications}},
  url          = {{http://dx.doi.org/10.1016/bs.pbr.2020.02.004}},
  doi          = {{10.1016/bs.pbr.2020.02.004}},
  volume       = {{252}},
  year         = {{2020}},
}