The role of glia in Parkinson's disease : Emerging concepts and therapeutic applications
Kuter, Katarzyna Z. LU ; Cenci, M. Angela LU
and Carta, Anna R.
(2020)
In Progress in Brain Research
252.
p.131-168
- Abstract
Originally believed to primarily affect neurons, Parkinson's disease (PD) has recently been recognized to also affect the functions and integrity of microglia and astroglia, two cell categories of fundamental importance to brain tissue homeostasis, defense, and repair. Both a loss of glial supportive-defensive functions and a toxic gain of glial functions are implicated in the neurodegenerative process. Moreover, the chronic treatment with L-DOPA may cause maladaptive glial plasticity favoring a development of therapy complications. This chapter focuses on the pathophysiology of PD from a glial point of view, presenting this rapidly growing field from the first discoveries made to the most recent developments. We report and compare... (More)
Originally believed to primarily affect neurons, Parkinson's disease (PD) has recently been recognized to also affect the functions and integrity of microglia and astroglia, two cell categories of fundamental importance to brain tissue homeostasis, defense, and repair. Both a loss of glial supportive-defensive functions and a toxic gain of glial functions are implicated in the neurodegenerative process. Moreover, the chronic treatment with L-DOPA may cause maladaptive glial plasticity favoring a development of therapy complications. This chapter focuses on the pathophysiology of PD from a glial point of view, presenting this rapidly growing field from the first discoveries made to the most recent developments. We report and compare histopathological and molecular findings from experimental models of PD and human studies. We moreover discuss the important role played by astrocytes in compensatory adaptations taking place during presymptomatic disease stages. We finally describe examples of potential therapeutic applications stemming from an increased understanding of the important roles of glia in PD.
(Less)
- author
- Kuter, Katarzyna Z.
LU
; Cenci, M. Angela
LU
and Carta, Anna R.
- organization
- publishing date
- 2020
- type
- Chapter in Book/Report/Conference proceeding
- publication status
- published
- subject
- keywords
- Astrocytes, Compensation, Dyskinesia, Energy metabolism, Grafting, Inflammation, Levodopa, Microglia, Pharmacology, α-Synuclein
- host publication
- Recent Advances in Parkinson's Disease
- series title
- Progress in Brain Research
- editor
- Björklund, Anders and Cenci, M. Angela
- volume
- 252
- pages
- 38 pages
- publisher
- Elsevier Science Publishers B.V.
- external identifiers
-
- pmid:32247363
- scopus:85081964251
- ISSN
- 0079-6123
- 1875-7855
- ISBN
- 9780444642608
- DOI
- 10.1016/bs.pbr.2020.02.004
- language
- English
- LU publication?
- yes
- id
- 5fa022fe-4e04-4b02-9fb8-40eaec43982d
- date added to LUP
- 2020-04-09 08:05:45
- date last changed
- 2024-06-13 14:20:44
@inbook{5fa022fe-4e04-4b02-9fb8-40eaec43982d,
abstract = {{<p>Originally believed to primarily affect neurons, Parkinson's disease (PD) has recently been recognized to also affect the functions and integrity of microglia and astroglia, two cell categories of fundamental importance to brain tissue homeostasis, defense, and repair. Both a loss of glial supportive-defensive functions and a toxic gain of glial functions are implicated in the neurodegenerative process. Moreover, the chronic treatment with L-DOPA may cause maladaptive glial plasticity favoring a development of therapy complications. This chapter focuses on the pathophysiology of PD from a glial point of view, presenting this rapidly growing field from the first discoveries made to the most recent developments. We report and compare histopathological and molecular findings from experimental models of PD and human studies. We moreover discuss the important role played by astrocytes in compensatory adaptations taking place during presymptomatic disease stages. We finally describe examples of potential therapeutic applications stemming from an increased understanding of the important roles of glia in PD.</p>}},
author = {{Kuter, Katarzyna Z. and Cenci, M. Angela and Carta, Anna R.}},
booktitle = {{Recent Advances in Parkinson's Disease}},
editor = {{Björklund, Anders and Cenci, M. Angela}},
isbn = {{9780444642608}},
issn = {{0079-6123}},
keywords = {{Astrocytes; Compensation; Dyskinesia; Energy metabolism; Grafting; Inflammation; Levodopa; Microglia; Pharmacology; α-Synuclein}},
language = {{eng}},
pages = {{131--168}},
publisher = {{Elsevier Science Publishers B.V.}},
series = {{Progress in Brain Research}},
title = {{The role of glia in Parkinson's disease : Emerging concepts and therapeutic applications}},
url = {{http://dx.doi.org/10.1016/bs.pbr.2020.02.004}},
doi = {{10.1016/bs.pbr.2020.02.004}},
volume = {{252}},
year = {{2020}},
}