Tissue Factor and Factor VIIa as Therapeutic Targets in Disorders of Hemostasis.
(2008) In Annual Review of Medicine 59. p.29-41- Abstract
- For hemophilia patients with inhibitors against FVIII or FIX, the development of recombinant factor VIIa (rFVIIa) raises the possibility of a therapeutic alternative whose availability and convenience of treatment are comparable to those of FVIII or FIX. In support of this new concept for the treatment of bleeding episodes, pharmacological doses of FVIIa have been shown to induce hemostasis. Pharmacological doses of rFVIIa enhance thrombin generation on thrombin-activated platelets, thereby facilitating the formation of strong, well-structured fibrin plugs resistant to premature proteolysis. Modified rFVIIa molecules with a stronger hemostatic potential have been produced. Inhibition of the FVII-TF-dependent pathway (TFPI and rFVIIai) has... (More)
- For hemophilia patients with inhibitors against FVIII or FIX, the development of recombinant factor VIIa (rFVIIa) raises the possibility of a therapeutic alternative whose availability and convenience of treatment are comparable to those of FVIII or FIX. In support of this new concept for the treatment of bleeding episodes, pharmacological doses of FVIIa have been shown to induce hemostasis. Pharmacological doses of rFVIIa enhance thrombin generation on thrombin-activated platelets, thereby facilitating the formation of strong, well-structured fibrin plugs resistant to premature proteolysis. Modified rFVIIa molecules with a stronger hemostatic potential have been produced. Inhibition of the FVII-TF-dependent pathway (TFPI and rFVIIai) has been tried in attempts to prevent thrombosis, with promising results in animal models so far not confirmed in clinical trials. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/607901
- author
- Hedner, Ulla LU and Ezban, Mirella
- organization
- publishing date
- 2008
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Annual Review of Medicine
- volume
- 59
- pages
- 29 - 41
- publisher
- Annual Reviews
- external identifiers
-
- wos:000253397600003
- scopus:39649106357
- ISSN
- 0066-4219
- DOI
- 10.1146/annurev.med.59.061606.095605
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Emergency medicine/Medicine/Surgery (013240200)
- id
- ed1226ec-b302-4de5-bc2c-37b2e5781b43 (old id 607901)
- alternative location
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17845136&dopt=Abstract
- date added to LUP
- 2016-04-01 12:09:58
- date last changed
- 2022-01-26 23:41:59
@article{ed1226ec-b302-4de5-bc2c-37b2e5781b43,
abstract = {{For hemophilia patients with inhibitors against FVIII or FIX, the development of recombinant factor VIIa (rFVIIa) raises the possibility of a therapeutic alternative whose availability and convenience of treatment are comparable to those of FVIII or FIX. In support of this new concept for the treatment of bleeding episodes, pharmacological doses of FVIIa have been shown to induce hemostasis. Pharmacological doses of rFVIIa enhance thrombin generation on thrombin-activated platelets, thereby facilitating the formation of strong, well-structured fibrin plugs resistant to premature proteolysis. Modified rFVIIa molecules with a stronger hemostatic potential have been produced. Inhibition of the FVII-TF-dependent pathway (TFPI and rFVIIai) has been tried in attempts to prevent thrombosis, with promising results in animal models so far not confirmed in clinical trials.}},
author = {{Hedner, Ulla and Ezban, Mirella}},
issn = {{0066-4219}},
language = {{eng}},
pages = {{29--41}},
publisher = {{Annual Reviews}},
series = {{Annual Review of Medicine}},
title = {{Tissue Factor and Factor VIIa as Therapeutic Targets in Disorders of Hemostasis.}},
url = {{http://dx.doi.org/10.1146/annurev.med.59.061606.095605}},
doi = {{10.1146/annurev.med.59.061606.095605}},
volume = {{59}},
year = {{2008}},
}