Intravenous immunoglobulin and anti-D in idiopathic thrombocytopenic purpura (ITP) : mechanisms of action
(1998) In Transfusion Science 19(3). p.94-289- Abstract
Infusion of large amounts of intravenous immunoglobulin (IVIG) or anti-D can reverse the low platelet count in patients with ITP within hours of the initiation of treatment. In some cases, the effects of IVIG appear to far outlast several half-lives of the product. Several mechanisms have been proposed to explain these rapid and long term effects and these will be discussed in this review.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/61054f2b-197b-49c5-b9d9-0a786283d51b
- author
- Lazarus, A H ; Freedman, J and Semple, J W LU
- publishing date
- 1998-09
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Antibodies, Anti-Idiotypic/immunology, Autoantibodies/immunology, Autoimmune Diseases/immunology, Blood Platelets/immunology, Clinical Trials as Topic, Half-Life, Humans, Immunoglobulin G/immunology, Immunoglobulin M/immunology, Immunoglobulins, Intravenous/therapeutic use, Isoantibodies/therapeutic use, Macrophage Activation, Mononuclear Phagocyte System/physiopathology, Purpura, Thrombocytopenic, Idiopathic/immunology, Rho(D) Immune Globulin
- in
- Transfusion Science
- volume
- 19
- issue
- 3
- pages
- 94 - 289
- publisher
- Pergamon Press Ltd.
- external identifiers
-
- scopus:0346390594
- pmid:10351141
- ISSN
- 0955-3886
- DOI
- 10.1016/s0955-3886(98)00043-5
- language
- English
- LU publication?
- no
- id
- 61054f2b-197b-49c5-b9d9-0a786283d51b
- date added to LUP
- 2022-11-09 15:27:42
- date last changed
- 2024-05-31 22:39:42
@article{61054f2b-197b-49c5-b9d9-0a786283d51b, abstract = {{<p>Infusion of large amounts of intravenous immunoglobulin (IVIG) or anti-D can reverse the low platelet count in patients with ITP within hours of the initiation of treatment. In some cases, the effects of IVIG appear to far outlast several half-lives of the product. Several mechanisms have been proposed to explain these rapid and long term effects and these will be discussed in this review.</p>}}, author = {{Lazarus, A H and Freedman, J and Semple, J W}}, issn = {{0955-3886}}, keywords = {{Antibodies, Anti-Idiotypic/immunology; Autoantibodies/immunology; Autoimmune Diseases/immunology; Blood Platelets/immunology; Clinical Trials as Topic; Half-Life; Humans; Immunoglobulin G/immunology; Immunoglobulin M/immunology; Immunoglobulins, Intravenous/therapeutic use; Isoantibodies/therapeutic use; Macrophage Activation; Mononuclear Phagocyte System/physiopathology; Purpura, Thrombocytopenic, Idiopathic/immunology; Rho(D) Immune Globulin}}, language = {{eng}}, number = {{3}}, pages = {{94--289}}, publisher = {{Pergamon Press Ltd.}}, series = {{Transfusion Science}}, title = {{Intravenous immunoglobulin and anti-D in idiopathic thrombocytopenic purpura (ITP) : mechanisms of action}}, url = {{http://dx.doi.org/10.1016/s0955-3886(98)00043-5}}, doi = {{10.1016/s0955-3886(98)00043-5}}, volume = {{19}}, year = {{1998}}, }