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Adverse Lipid and Inflammatory Changes in Young Nondiabetic First-Degree Relatives of Type 1-Diabetic Patients

Englund, Emma LU ; Maxedius, Annica LU ; Odermarsky, Michal LU orcid and Liuba, Petru LU (2018) 52nd Annual meeting of the Association for European Paediatric and Congenital Caardiology In Cardiology in the Young 28(S1). p.43-44
Abstract
Background: Previous studies from our and other centers on young patients with type 1 diabetes (T1D) have indicated pro-atherosclerotic changes in the carotid arteries and in the lipid and systemic inflammatory profiles without a clear relationship between these changes and the hyperglycemic control. We have also earlier found in these patients a certain HLA-related genetic susceptibility to adverse vascular changes.Objective: To assess whether pro-atherosclerotic changes are present in apparently healthy first- degree relatives of patients with T1D.Methods: Plasma lipids, C-peptide (index of insulin secretion), C-reactive protein (CRP), and the carotid artery intima-media thickness (CA-IMT), compliance (CAC) and stiffness index (SI) were... (More)
Background: Previous studies from our and other centers on young patients with type 1 diabetes (T1D) have indicated pro-atherosclerotic changes in the carotid arteries and in the lipid and systemic inflammatory profiles without a clear relationship between these changes and the hyperglycemic control. We have also earlier found in these patients a certain HLA-related genetic susceptibility to adverse vascular changes.Objective: To assess whether pro-atherosclerotic changes are present in apparently healthy first- degree relatives of patients with T1D.Methods: Plasma lipids, C-peptide (index of insulin secretion), C-reactive protein (CRP), and the carotid artery intima-media thickness (CA-IMT), compliance (CAC) and stiffness index (SI) were assessed in up to 116 non-diabetic first-degree relatives (FDR; mean age: 12.6 years; 56 female) of patients with T1D and in up to 43 age-matched control individuals (mean age: 13.3 years; 23 female) without heredity for cardiovascular risk factors. The number and type of clinically manifest acute infections during the past year were obtained via a questionnaire validated in our previous studies.Results: There was no difference in age, gender, body mass index, arterial blood pressure and C- peptide levels between the FDR and control groups (p>0.2). Also, there was no significant difference in SI (p=0.2), CAC (p=0.1) and CA-IMT (p=0.9) between the groups. In the FDR group, plasma CRP and LDL- cholesterol (LDL-C) were increased (p<0.05 for both) and HDL-C was decreased (p<0.0001) as compared to the control group. The changes in LDL-C and HDL-C were most marked in FDR individuals with ≥ 4 acute respiratory infections during the past year (Figure).Conclusion: Adverse lipidemic and inflammatory changes are present in healthy non-diabetic first- degree relatives of T1D patients, probably related to their genetic susceptibility to this disease. Further analyses of additional indices of peripheral arterial function in these groups are under way. (Less)
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author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Cardiology in the Young
volume
28
issue
S1
article number
MP1-8
pages
43 - 44
publisher
Cambridge University Press
conference name
52nd Annual meeting of the Association for European Paediatric and Congenital Caardiology
conference location
Athens, Greece
conference dates
2018-05-09 - 2018-05-12
ISSN
1467-1107
DOI
10.1017/S1047951118000318
language
English
LU publication?
yes
id
6255e459-8fcc-46d0-a460-4291149361a2
date added to LUP
2018-05-13 20:17:58
date last changed
2021-03-22 16:20:29
@misc{6255e459-8fcc-46d0-a460-4291149361a2,
  abstract     = {{Background: Previous studies from our and other centers on young patients with type 1 diabetes (T1D) have indicated pro-atherosclerotic changes in the carotid arteries and in the lipid and systemic inflammatory profiles without a clear relationship between these changes and the hyperglycemic control. We have also earlier found in these patients a certain HLA-related genetic susceptibility to adverse vascular changes.Objective: To assess whether pro-atherosclerotic changes are present in apparently healthy first- degree relatives of patients with T1D.Methods: Plasma lipids, C-peptide (index of insulin secretion), C-reactive protein (CRP), and the carotid artery intima-media thickness (CA-IMT), compliance (CAC) and stiffness index (SI) were assessed in up to 116 non-diabetic first-degree relatives (FDR; mean age: 12.6 years; 56 female) of patients with T1D and in up to 43 age-matched control individuals (mean age: 13.3 years; 23 female) without heredity for cardiovascular risk factors. The number and type of clinically manifest acute infections during the past year were obtained via a questionnaire validated in our previous studies.Results: There was no difference in age, gender, body mass index, arterial blood pressure and C- peptide levels between the FDR and control groups (p&gt;0.2). Also, there was no significant difference in SI (p=0.2), CAC (p=0.1) and CA-IMT (p=0.9) between the groups. In the FDR group, plasma CRP and LDL- cholesterol (LDL-C) were increased (p&lt;0.05 for both) and HDL-C was decreased (p&lt;0.0001) as compared to the control group. The changes in LDL-C and HDL-C were most marked in FDR individuals with ≥ 4 acute respiratory infections during the past year (Figure).Conclusion: Adverse lipidemic and inflammatory changes are present in healthy non-diabetic first- degree relatives of T1D patients, probably related to their genetic susceptibility to this disease. Further analyses of additional indices of peripheral arterial function in these groups are under way.}},
  author       = {{Englund, Emma and Maxedius, Annica and Odermarsky, Michal and Liuba, Petru}},
  issn         = {{1467-1107}},
  language     = {{eng}},
  note         = {{Conference Abstract}},
  number       = {{S1}},
  pages        = {{43--44}},
  publisher    = {{Cambridge University Press}},
  series       = {{Cardiology in the Young}},
  title        = {{Adverse Lipid and Inflammatory Changes in Young Nondiabetic First-Degree Relatives of Type 1-Diabetic Patients}},
  url          = {{http://dx.doi.org/10.1017/S1047951118000318}},
  doi          = {{10.1017/S1047951118000318}},
  volume       = {{28}},
  year         = {{2018}},
}