Dystroglycan: a possible mediator for reducing congenital muscular dystrophy?
(2007) In Trends in Biotechnology 25(6). p.262-268- Abstract
- alpha-Dystroglycan is a highly glycosylated peripheral protein forming a complex with the membrane-spanning beta-dystroglycan and establishing a connection between the extracellular matrix and the cytoskeleton. In skeletal muscle, as part of the larger dystrophin-glycoprotein complex, dystroglycan is believed to be essential for maintaining the structural and functional stability of muscle fibers. Recent work highlights the role of abnormal dystroglycan glycosylation at the basis of glycosyltransferase-deficient congenital muscular dystrophies. Notably, modulation of glycosyltransferase activity can restore alpha-dystroglycan receptor function in these disorders. Moreover, transgenic approaches favoring the interaction between dystroglycan... (More)
- alpha-Dystroglycan is a highly glycosylated peripheral protein forming a complex with the membrane-spanning beta-dystroglycan and establishing a connection between the extracellular matrix and the cytoskeleton. In skeletal muscle, as part of the larger dystrophin-glycoprotein complex, dystroglycan is believed to be essential for maintaining the structural and functional stability of muscle fibers. Recent work highlights the role of abnormal dystroglycan glycosylation at the basis of glycosyltransferase-deficient congenital muscular dystrophies. Notably, modulation of glycosyltransferase activity can restore alpha-dystroglycan receptor function in these disorders. Moreover, transgenic approaches favoring the interaction between dystroglycan and the extracellular matrix molecules also represent an innovative way to restore skeletal muscle structure. These pioneering approaches might comprise an important first step towards the design of gene-transfer-based strategies for the rescue of congenital muscular dystrophies involving dystroglycan. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/648616
- author
- Sciandra, Francesca ; Gawlik, Kinga LU ; Brancaccio, Andrea and Durbeej-Hjalt, Madeleine LU
- organization
- publishing date
- 2007
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Trends in Biotechnology
- volume
- 25
- issue
- 6
- pages
- 262 - 268
- publisher
- Elsevier
- external identifiers
-
- wos:000247252200006
- scopus:34248562605
- ISSN
- 0167-7799
- DOI
- 10.1016/j.tibtech.2007.04.002
- language
- English
- LU publication?
- yes
- id
- 830b6860-5ab4-4216-b8b1-a083e20b4f23 (old id 648616)
- date added to LUP
- 2016-04-01 12:31:17
- date last changed
- 2022-03-21 05:27:30
@article{830b6860-5ab4-4216-b8b1-a083e20b4f23,
abstract = {{alpha-Dystroglycan is a highly glycosylated peripheral protein forming a complex with the membrane-spanning beta-dystroglycan and establishing a connection between the extracellular matrix and the cytoskeleton. In skeletal muscle, as part of the larger dystrophin-glycoprotein complex, dystroglycan is believed to be essential for maintaining the structural and functional stability of muscle fibers. Recent work highlights the role of abnormal dystroglycan glycosylation at the basis of glycosyltransferase-deficient congenital muscular dystrophies. Notably, modulation of glycosyltransferase activity can restore alpha-dystroglycan receptor function in these disorders. Moreover, transgenic approaches favoring the interaction between dystroglycan and the extracellular matrix molecules also represent an innovative way to restore skeletal muscle structure. These pioneering approaches might comprise an important first step towards the design of gene-transfer-based strategies for the rescue of congenital muscular dystrophies involving dystroglycan.}},
author = {{Sciandra, Francesca and Gawlik, Kinga and Brancaccio, Andrea and Durbeej-Hjalt, Madeleine}},
issn = {{0167-7799}},
language = {{eng}},
number = {{6}},
pages = {{262--268}},
publisher = {{Elsevier}},
series = {{Trends in Biotechnology}},
title = {{Dystroglycan: a possible mediator for reducing congenital muscular dystrophy?}},
url = {{http://dx.doi.org/10.1016/j.tibtech.2007.04.002}},
doi = {{10.1016/j.tibtech.2007.04.002}},
volume = {{25}},
year = {{2007}},
}