Association of microsatellite polymorphisms of the human 14q13.2 region with type 2 diabetes mellitus in latvian and finnish populations
(2007) In Annals of Human Genetics 71. p.772-776- Abstract
- A polymorphic microsatellite in intron 6 of the human proteasome core particle PSMA6 gene (HSMS006), and four other microsatellites localized upstream on human chromosome 14q13.2 (HSMS801, HSMS702, HSMS701, HSMS602), were genotyped in 104 type 2 diabetic patients and 129 age-matched control subjects from Latvia and replicated in 91 type 2 diabetic patients and 88 age-matched healthy control subjects from the Botnia Study in Finland. In type 2 diabetic patients from both populations the HSMS006 (TG)22 allele was two times more frequent compared to the control group. In the Latvian population the (CAA)8 allele of the HSMS602 marker was less frequent in the diabetic group, as was the (AC)24 allele of microsatellite HSMS801. Allele frequencies... (More)
- A polymorphic microsatellite in intron 6 of the human proteasome core particle PSMA6 gene (HSMS006), and four other microsatellites localized upstream on human chromosome 14q13.2 (HSMS801, HSMS702, HSMS701, HSMS602), were genotyped in 104 type 2 diabetic patients and 129 age-matched control subjects from Latvia and replicated in 91 type 2 diabetic patients and 88 age-matched healthy control subjects from the Botnia Study in Finland. In type 2 diabetic patients from both populations the HSMS006 (TG)22 allele was two times more frequent compared to the control group. In the Latvian population the (CAA)8 allele of the HSMS602 marker was less frequent in the diabetic group, as was the (AC)24 allele of microsatellite HSMS801. Allele frequencies of the HSMS701 and 702 repeats were similar in healthy controls and type 2 diabetic patients. In conclusion, our data suggest that variants in the PSMA6 gene on chromosome 14q13.2 are associated with type 2 diabetes. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/655805
- author
- Sjakste, T. ; Kalis, M. ; Poudziunas, I. ; Pirags, V. ; Lazdins, M. ; Groop, Leif LU and Sjakste, N.
- organization
- publishing date
- 2007
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- proteasomes, Chromosome 14, type 2 diabetes mellitus, microsatellites, PSMA6, polymorphism
- in
- Annals of Human Genetics
- volume
- 71
- pages
- 772 - 776
- publisher
- Wiley-Blackwell
- external identifiers
-
- wos:000249923200009
- scopus:34948885086
- ISSN
- 1469-1809
- DOI
- 10.1111/j.1469-1809.2007.00372.x
- language
- English
- LU publication?
- yes
- id
- 652c581e-23ae-4989-b0b3-d8ffe867de52 (old id 655805)
- date added to LUP
- 2016-04-01 12:18:07
- date last changed
- 2024-01-08 15:44:57
@article{652c581e-23ae-4989-b0b3-d8ffe867de52, abstract = {{A polymorphic microsatellite in intron 6 of the human proteasome core particle PSMA6 gene (HSMS006), and four other microsatellites localized upstream on human chromosome 14q13.2 (HSMS801, HSMS702, HSMS701, HSMS602), were genotyped in 104 type 2 diabetic patients and 129 age-matched control subjects from Latvia and replicated in 91 type 2 diabetic patients and 88 age-matched healthy control subjects from the Botnia Study in Finland. In type 2 diabetic patients from both populations the HSMS006 (TG)22 allele was two times more frequent compared to the control group. In the Latvian population the (CAA)8 allele of the HSMS602 marker was less frequent in the diabetic group, as was the (AC)24 allele of microsatellite HSMS801. Allele frequencies of the HSMS701 and 702 repeats were similar in healthy controls and type 2 diabetic patients. In conclusion, our data suggest that variants in the PSMA6 gene on chromosome 14q13.2 are associated with type 2 diabetes.}}, author = {{Sjakste, T. and Kalis, M. and Poudziunas, I. and Pirags, V. and Lazdins, M. and Groop, Leif and Sjakste, N.}}, issn = {{1469-1809}}, keywords = {{proteasomes; Chromosome 14; type 2 diabetes mellitus; microsatellites; PSMA6; polymorphism}}, language = {{eng}}, pages = {{772--776}}, publisher = {{Wiley-Blackwell}}, series = {{Annals of Human Genetics}}, title = {{Association of microsatellite polymorphisms of the human 14q13.2 region with type 2 diabetes mellitus in latvian and finnish populations}}, url = {{http://dx.doi.org/10.1111/j.1469-1809.2007.00372.x}}, doi = {{10.1111/j.1469-1809.2007.00372.x}}, volume = {{71}}, year = {{2007}}, }