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Long-term follow-up of the hepatitis CHENCORE cohort: response to therapy and occurrence of liver-related complications

Pradat, P. ; Tillmann, H. L. ; Sauleda, S. ; Braconier, Jean Henrik LU ; Saracco, G. ; Thursz, M. ; Goldin, R. ; Winkler, R. ; Alberti, A. and Esteban, J.-I. , et al. (2007) In Journal of Viral Hepatitis 14(8). p.556-563
Abstract
The aims of the study were to verify the longterm effect of time on viral clearance in hepatitis C virus (HCV) patients and to find out factors possibly associated with disease progression. A total of 1641 patients recruited from eight European centres in 1996-1.997 were re-analysed 5-7 years after inclusion. The occurrence of decompensated cirrhosis, hepatocellular carcinoma (HCC) and liver transplantation was analysed in relation to different host and viral factors. Ninety-three per cent of the HCV patients who had cleared the virus (spontaneously or after antiviral therapy) remained HCV-RNA-negative during follow up and may be considered as 'cured'. Among patients who were sustained responders at inclusion, 2.3% developed liver... (More)
The aims of the study were to verify the longterm effect of time on viral clearance in hepatitis C virus (HCV) patients and to find out factors possibly associated with disease progression. A total of 1641 patients recruited from eight European centres in 1996-1.997 were re-analysed 5-7 years after inclusion. The occurrence of decompensated cirrhosis, hepatocellular carcinoma (HCC) and liver transplantation was analysed in relation to different host and viral factors. Ninety-three per cent of the HCV patients who had cleared the virus (spontaneously or after antiviral therapy) remained HCV-RNA-negative during follow up and may be considered as 'cured'. Among patients who were sustained responders at inclusion, 2.3% developed liver complications during follow up, and 31% of non-responders did. Advanced age at infection and presence of the human leucocyte antigen (HLA) DRBI*1201-3 allele were possibly associated with a higher rate of progression to decompen- sated cirrhosis or HCC. Decompensated cirrhosis might be further associated with male gender, non-response to previous therapy, and lack of FILA DRBI*1301 allele, whereas HCC seems to be associated with the presence of the HLA DQ02 allele. Long-term follow up of HCV patients indicates that virological response persists over time and is associated with a very low incidence of liver complications. Advanced age at inclusion. advanced age at infection, viral genotype 1, non-response to previous therapy and possibly some specific HLA alleles are factors independently associated with a faster rate of progression towards liver complications. The large proportion of patients lost to follow up stresses the need for a strengthened and optimized management of HCV patients. (Less)
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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
human leucocyte antigen, carcinoma, hepatocellular, hepatitis C, follow up, cirrhosis, complications, viral clearance
in
Journal of Viral Hepatitis
volume
14
issue
8
pages
556 - 563
publisher
Wiley-Blackwell
external identifiers
  • wos:000248483100004
  • scopus:34447545514
ISSN
1365-2893
DOI
10.1111/j.1365-2893.2006.00829.x
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Division of Infection Medicine (SUS) (013008000)
id
05158168-7cd0-4331-a4f4-902e26021026 (old id 657096)
date added to LUP
2016-04-01 12:20:26
date last changed
2022-01-27 02:12:58
@article{05158168-7cd0-4331-a4f4-902e26021026,
  abstract     = {{The aims of the study were to verify the longterm effect of time on viral clearance in hepatitis C virus (HCV) patients and to find out factors possibly associated with disease progression. A total of 1641 patients recruited from eight European centres in 1996-1.997 were re-analysed 5-7 years after inclusion. The occurrence of decompensated cirrhosis, hepatocellular carcinoma (HCC) and liver transplantation was analysed in relation to different host and viral factors. Ninety-three per cent of the HCV patients who had cleared the virus (spontaneously or after antiviral therapy) remained HCV-RNA-negative during follow up and may be considered as 'cured'. Among patients who were sustained responders at inclusion, 2.3% developed liver complications during follow up, and 31% of non-responders did. Advanced age at infection and presence of the human leucocyte antigen (HLA) DRBI*1201-3 allele were possibly associated with a higher rate of progression to decompen- sated cirrhosis or HCC. Decompensated cirrhosis might be further associated with male gender, non-response to previous therapy, and lack of FILA DRBI*1301 allele, whereas HCC seems to be associated with the presence of the HLA DQ02 allele. Long-term follow up of HCV patients indicates that virological response persists over time and is associated with a very low incidence of liver complications. Advanced age at inclusion. advanced age at infection, viral genotype 1, non-response to previous therapy and possibly some specific HLA alleles are factors independently associated with a faster rate of progression towards liver complications. The large proportion of patients lost to follow up stresses the need for a strengthened and optimized management of HCV patients.}},
  author       = {{Pradat, P. and Tillmann, H. L. and Sauleda, S. and Braconier, Jean Henrik and Saracco, G. and Thursz, M. and Goldin, R. and Winkler, R. and Alberti, A. and Esteban, J.-I. and Hadziyannis, S. and Rizzetto, M. and Thomas, H. and Manns, M. P. and Trepo, C.}},
  issn         = {{1365-2893}},
  keywords     = {{human leucocyte antigen; carcinoma; hepatocellular; hepatitis C; follow up; cirrhosis; complications; viral clearance}},
  language     = {{eng}},
  number       = {{8}},
  pages        = {{556--563}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{Journal of Viral Hepatitis}},
  title        = {{Long-term follow-up of the hepatitis CHENCORE cohort: response to therapy and occurrence of liver-related complications}},
  url          = {{http://dx.doi.org/10.1111/j.1365-2893.2006.00829.x}},
  doi          = {{10.1111/j.1365-2893.2006.00829.x}},
  volume       = {{14}},
  year         = {{2007}},
}