Plum-pudding gels as a platform for drug delivery: Understanding the effects of the different components on the diffusion behavior of solutes
(2007) In The Journal of Physical Chemistry Part B 111(25). p.7367-7376- Abstract
- The internal structure of composite gels made of responsive microgel particles inserted into a bulk hydrogel (N-isopropylacrylamide microgel particles in a cross-linked dimethylacrylamide matrix) has been investigated from the diffusion behavior of poly(ethylene glycol) (PEG) probes through the network, in the absence of specific interactions between the diffusing molecules and the system. The effect of the different components has been examined, for example, the size of the probe, the bulk structure, and the microgel nature. Particles were characterized prior to their insertion into the hydrogel in order to describe their properties as a function of size and cross-linker content, thus revealing different swelling behaviors. The biggest... (More)
- The internal structure of composite gels made of responsive microgel particles inserted into a bulk hydrogel (N-isopropylacrylamide microgel particles in a cross-linked dimethylacrylamide matrix) has been investigated from the diffusion behavior of poly(ethylene glycol) (PEG) probes through the network, in the absence of specific interactions between the diffusing molecules and the system. The effect of the different components has been examined, for example, the size of the probe, the bulk structure, and the microgel nature. Particles were characterized prior to their insertion into the hydrogel in order to describe their properties as a function of size and cross-linker content, thus revealing different swelling behaviors. The biggest effects on the diffusion of the PEG probes were related to the bulk structure, and no major effects were registered by the addition of different microgels into the hydrogel network. We attempt to rationalize this behavior in terms of the composite gel structure and discuss the results in terms of their meaning for controlled drug delivery strategies. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/657460
- author
- Salvati, Anna LU ; Söderman, Olle LU and Lynch, Iseult LU
- organization
- publishing date
- 2007
- type
- Contribution to journal
- publication status
- published
- subject
- in
- The Journal of Physical Chemistry Part B
- volume
- 111
- issue
- 25
- pages
- 7367 - 7376
- publisher
- The American Chemical Society (ACS)
- external identifiers
-
- wos:000247435700054
- scopus:34547292379
- pmid:17547442
- ISSN
- 1520-5207
- DOI
- 10.1021/jp069051u
- language
- English
- LU publication?
- yes
- id
- dfae35eb-9fa5-4dc0-bbd6-b2054382567e (old id 657460)
- date added to LUP
- 2016-04-01 16:14:00
- date last changed
- 2022-01-28 18:12:17
@article{dfae35eb-9fa5-4dc0-bbd6-b2054382567e,
abstract = {{The internal structure of composite gels made of responsive microgel particles inserted into a bulk hydrogel (N-isopropylacrylamide microgel particles in a cross-linked dimethylacrylamide matrix) has been investigated from the diffusion behavior of poly(ethylene glycol) (PEG) probes through the network, in the absence of specific interactions between the diffusing molecules and the system. The effect of the different components has been examined, for example, the size of the probe, the bulk structure, and the microgel nature. Particles were characterized prior to their insertion into the hydrogel in order to describe their properties as a function of size and cross-linker content, thus revealing different swelling behaviors. The biggest effects on the diffusion of the PEG probes were related to the bulk structure, and no major effects were registered by the addition of different microgels into the hydrogel network. We attempt to rationalize this behavior in terms of the composite gel structure and discuss the results in terms of their meaning for controlled drug delivery strategies.}},
author = {{Salvati, Anna and Söderman, Olle and Lynch, Iseult}},
issn = {{1520-5207}},
language = {{eng}},
number = {{25}},
pages = {{7367--7376}},
publisher = {{The American Chemical Society (ACS)}},
series = {{The Journal of Physical Chemistry Part B}},
title = {{Plum-pudding gels as a platform for drug delivery: Understanding the effects of the different components on the diffusion behavior of solutes}},
url = {{http://dx.doi.org/10.1021/jp069051u}},
doi = {{10.1021/jp069051u}},
volume = {{111}},
year = {{2007}},
}