Effect of nicotine 6 mg gum on urges to smoke, a randomized clinical trial
(2019) In BMC Pharmacology and Toxicology 20(1).- Abstract
Background: Ability to manage urges to smoke is fundamental to maximizing the chances of success in smoking cessation. Previous studies have linked a higher dose of nicotine in nicotine replacement therapy to a higher success rate for smoking cessation. Thus, this study was performed to compare relief of urges to smoke, up until 5 h following treatment with a new 6 mg nicotine gum versus currently marketed 4 mg nicotine gum. Methods: This was a randomized crossover clinical study. Following 12 h of abstinence from smoking, either one 6 mg or one 4 mg nicotine gum was given to 240 healthy adult smokers. Thereafter, urges to smoke were scored on a 100 mm Visual Analogue Scale repeatedly over 5 h. Results: The reductions in urges to smoke... (More)
Background: Ability to manage urges to smoke is fundamental to maximizing the chances of success in smoking cessation. Previous studies have linked a higher dose of nicotine in nicotine replacement therapy to a higher success rate for smoking cessation. Thus, this study was performed to compare relief of urges to smoke, up until 5 h following treatment with a new 6 mg nicotine gum versus currently marketed 4 mg nicotine gum. Methods: This was a randomized crossover clinical study. Following 12 h of abstinence from smoking, either one 6 mg or one 4 mg nicotine gum was given to 240 healthy adult smokers. Thereafter, urges to smoke were scored on a 100 mm Visual Analogue Scale repeatedly over 5 h. Results: The reductions in urges to smoke over the first 1 and 3 h after administration were statistically significantly greater with 6 mg than 4 mg gum, (p < 0.005). A 50% reduction in perceived urges to smoke was reached in 9.4 min with 6 mg gum compared to 16.2 min with 4 mg gum (median values). The median duration of a 50% or more reduction in VAS urges to smoke score was 111 min with the 6 mg gum, versus 74 min for the 4 mg gum. Conclusion: This study provides evidence that the 6 mg nicotine gum provided a greater reduction, faster and longer relief of urges to smoke than the 4 mg nicotine gum. Trial registration: EudraCT Number: 2010-023268-42. Study was first entered in EudraCT 2011-02-23.
(Less)
- author
- Hansson, Anna LU ; Rasmussen, Thomas ; Perfekt, Roland LU ; Hall, Elin LU and Kraiczi, Holger LU
- organization
- publishing date
- 2019-11-21
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Clinical trial, Craving relief, Nicotine replacement therapy, Smoking cessation, Urges to smoke
- in
- BMC Pharmacology and Toxicology
- volume
- 20
- issue
- 1
- article number
- 69
- publisher
- BioMed Central (BMC)
- external identifiers
-
- pmid:31753009
- scopus:85075536582
- ISSN
- 2050-6511
- DOI
- 10.1186/s40360-019-0368-9
- language
- English
- LU publication?
- yes
- id
- 65954ba1-107e-4101-b438-a4e2b0e367b1
- date added to LUP
- 2019-12-05 08:39:12
- date last changed
- 2024-09-04 13:53:38
@article{65954ba1-107e-4101-b438-a4e2b0e367b1,
abstract = {{<p>Background: Ability to manage urges to smoke is fundamental to maximizing the chances of success in smoking cessation. Previous studies have linked a higher dose of nicotine in nicotine replacement therapy to a higher success rate for smoking cessation. Thus, this study was performed to compare relief of urges to smoke, up until 5 h following treatment with a new 6 mg nicotine gum versus currently marketed 4 mg nicotine gum. Methods: This was a randomized crossover clinical study. Following 12 h of abstinence from smoking, either one 6 mg or one 4 mg nicotine gum was given to 240 healthy adult smokers. Thereafter, urges to smoke were scored on a 100 mm Visual Analogue Scale repeatedly over 5 h. Results: The reductions in urges to smoke over the first 1 and 3 h after administration were statistically significantly greater with 6 mg than 4 mg gum, (p < 0.005). A 50% reduction in perceived urges to smoke was reached in 9.4 min with 6 mg gum compared to 16.2 min with 4 mg gum (median values). The median duration of a 50% or more reduction in VAS urges to smoke score was 111 min with the 6 mg gum, versus 74 min for the 4 mg gum. Conclusion: This study provides evidence that the 6 mg nicotine gum provided a greater reduction, faster and longer relief of urges to smoke than the 4 mg nicotine gum. Trial registration: EudraCT Number: 2010-023268-42. Study was first entered in EudraCT 2011-02-23.</p>}},
author = {{Hansson, Anna and Rasmussen, Thomas and Perfekt, Roland and Hall, Elin and Kraiczi, Holger}},
issn = {{2050-6511}},
keywords = {{Clinical trial; Craving relief; Nicotine replacement therapy; Smoking cessation; Urges to smoke}},
language = {{eng}},
month = {{11}},
number = {{1}},
publisher = {{BioMed Central (BMC)}},
series = {{BMC Pharmacology and Toxicology}},
title = {{Effect of nicotine 6 mg gum on urges to smoke, a randomized clinical trial}},
url = {{http://dx.doi.org/10.1186/s40360-019-0368-9}},
doi = {{10.1186/s40360-019-0368-9}},
volume = {{20}},
year = {{2019}},
}