Evaluation of fluorescently labeled xylopyranosides as probes for proteoglycan biosynthesis
(2007) In Bioorganic & Medicinal Chemistry Letters 17(8). p.2338-2341- Abstract
- A new fluorescent analog to the antiproliferative 2-(6-hydroxynaphthyl)-beta-D-xylopyranoside has been synthesized and tested on a T24 cell line. The new analog was efficiently uptaken by the T24 cells but did not initiate priming of GAG chains. The results are similar to other fluorescently labeled analogs and we propose that these compounds are too large and unpolar to efficiently function as GAG-primers. (c) 2007 Elsevier Ltd. All rights reserved.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/663688
- author
- Johnsson, Richard LU ; Mani, Katrin LU and Ellervik, Ulf LU
- organization
- publishing date
- 2007
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- glycosaminoglycan, fluorescent, carbohydrates, xylose, proteoglycan
- in
- Bioorganic & Medicinal Chemistry Letters
- volume
- 17
- issue
- 8
- pages
- 2338 - 2341
- publisher
- Elsevier
- external identifiers
-
- wos:000246045900045
- scopus:33947683396
- pmid:17291749
- ISSN
- 0960-894X
- DOI
- 10.1016/j.bmcl.2007.01.063
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Organic chemistry (S/LTH) (011001240), Glycobiology (013212006)
- id
- 5b270ca6-7742-4b50-91ba-88e4f93b5c4c (old id 663688)
- date added to LUP
- 2016-04-01 11:34:56
- date last changed
- 2024-02-06 01:22:45
@article{5b270ca6-7742-4b50-91ba-88e4f93b5c4c, abstract = {{A new fluorescent analog to the antiproliferative 2-(6-hydroxynaphthyl)-beta-D-xylopyranoside has been synthesized and tested on a T24 cell line. The new analog was efficiently uptaken by the T24 cells but did not initiate priming of GAG chains. The results are similar to other fluorescently labeled analogs and we propose that these compounds are too large and unpolar to efficiently function as GAG-primers. (c) 2007 Elsevier Ltd. All rights reserved.}}, author = {{Johnsson, Richard and Mani, Katrin and Ellervik, Ulf}}, issn = {{0960-894X}}, keywords = {{glycosaminoglycan; fluorescent; carbohydrates; xylose; proteoglycan}}, language = {{eng}}, number = {{8}}, pages = {{2338--2341}}, publisher = {{Elsevier}}, series = {{Bioorganic & Medicinal Chemistry Letters}}, title = {{Evaluation of fluorescently labeled xylopyranosides as probes for proteoglycan biosynthesis}}, url = {{http://dx.doi.org/10.1016/j.bmcl.2007.01.063}}, doi = {{10.1016/j.bmcl.2007.01.063}}, volume = {{17}}, year = {{2007}}, }