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Small bowel capsule endoscopy in obscure gastrointestinal bleeding : A matched cohort comparison of patients with normal vs surgically altered gastric anatomy

Dray, Xavier ; Rahmi, Gabriel ; Riccioni, Maria Elena ; Vanbiervliet, Geoffroy ; Johansson, Gabriele Wurm LU ; Leandri, Chloé ; Baltes, Peter ; Duburque, Clotilde ; Cholet, Franck and Koulaouzidis, Anastasios LU , et al. (2022) In Clinics and Research in Hepatology and Gastroenterology 46(7).
Abstract

Background: Little is known about small bowel capsule endoscopy (SBCE) outcomes in patients with surgically altered anatomy. Aims: To assess the feasibility and diagnostic yield of orally ingested SBCE to investigate obscure gastrointestinal bleeding (OGIB) in patients with surgically altered gastric anatomy, compared to native gastric anatomy. Methods: 207 patients with OGIB were selected from an open, multicenter, retrospective cohort (SAGA study) and match-paired according to age, gender and bleeding type (overt/occult) to 207 control patients from a randomized controlled trial (PREPINTEST). Primary outcomes were the diagnostic yield (P1 or P2 findings), completion rate, adverse events rate, and small bowel transit time (SBTT).... (More)

Background: Little is known about small bowel capsule endoscopy (SBCE) outcomes in patients with surgically altered anatomy. Aims: To assess the feasibility and diagnostic yield of orally ingested SBCE to investigate obscure gastrointestinal bleeding (OGIB) in patients with surgically altered gastric anatomy, compared to native gastric anatomy. Methods: 207 patients with OGIB were selected from an open, multicenter, retrospective cohort (SAGA study) and match-paired according to age, gender and bleeding type (overt/occult) to 207 control patients from a randomized controlled trial (PREPINTEST). Primary outcomes were the diagnostic yield (P1 or P2 findings), completion rate, adverse events rate, and small bowel transit time (SBTT). Results: The diagnostic yield was not statistically different between groups (44.9% in SAGA vs 42.5% in control patients). Inflammatory/ulcerated lesions were significantly more frequent in patients with SAGA (43.0% vs 29.3%). The median SBTT was significantly longer in the SAGA group than in control patients (283 vs 206 minutes), with a significantly lower completion rate (82.6% vs 89.9%); Adverse events were scarce (0.5% vs 0.0%). Conclusion: Patients with surgically altered gastric anatomy should benefit from SBCE investigation for OGIB as much as non-operated patients.

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type
Contribution to journal
publication status
published
subject
keywords
Capsule endoscopy, Gastrectomy, Gastrointesintal bleeding, Small bowel bleeding
in
Clinics and Research in Hepatology and Gastroenterology
volume
46
issue
7
article number
101921
publisher
Elsevier Masson SAS
external identifiers
  • scopus:85130337658
  • pmid:35390539
ISSN
2210-7401
DOI
10.1016/j.clinre.2022.101921
language
English
LU publication?
yes
id
669a846f-6c10-4796-9beb-38248180ab20
date added to LUP
2022-12-28 13:21:11
date last changed
2024-07-12 00:52:58
@article{669a846f-6c10-4796-9beb-38248180ab20,
  abstract     = {{<p>Background: Little is known about small bowel capsule endoscopy (SBCE) outcomes in patients with surgically altered anatomy. Aims: To assess the feasibility and diagnostic yield of orally ingested SBCE to investigate obscure gastrointestinal bleeding (OGIB) in patients with surgically altered gastric anatomy, compared to native gastric anatomy. Methods: 207 patients with OGIB were selected from an open, multicenter, retrospective cohort (SAGA study) and match-paired according to age, gender and bleeding type (overt/occult) to 207 control patients from a randomized controlled trial (PREPINTEST). Primary outcomes were the diagnostic yield (P1 or P2 findings), completion rate, adverse events rate, and small bowel transit time (SBTT). Results: The diagnostic yield was not statistically different between groups (44.9% in SAGA vs 42.5% in control patients). Inflammatory/ulcerated lesions were significantly more frequent in patients with SAGA (43.0% vs 29.3%). The median SBTT was significantly longer in the SAGA group than in control patients (283 vs 206 minutes), with a significantly lower completion rate (82.6% vs 89.9%); Adverse events were scarce (0.5% vs 0.0%). Conclusion: Patients with surgically altered gastric anatomy should benefit from SBCE investigation for OGIB as much as non-operated patients.</p>}},
  author       = {{Dray, Xavier and Rahmi, Gabriel and Riccioni, Maria Elena and Vanbiervliet, Geoffroy and Johansson, Gabriele Wurm and Leandri, Chloé and Baltes, Peter and Duburque, Clotilde and Cholet, Franck and Koulaouzidis, Anastasios and Quénéhervé, Lucille}},
  issn         = {{2210-7401}},
  keywords     = {{Capsule endoscopy; Gastrectomy; Gastrointesintal bleeding; Small bowel bleeding}},
  language     = {{eng}},
  month        = {{08}},
  number       = {{7}},
  publisher    = {{Elsevier Masson SAS}},
  series       = {{Clinics and Research in Hepatology and Gastroenterology}},
  title        = {{Small bowel capsule endoscopy in obscure gastrointestinal bleeding : A matched cohort comparison of patients with normal vs surgically altered gastric anatomy}},
  url          = {{http://dx.doi.org/10.1016/j.clinre.2022.101921}},
  doi          = {{10.1016/j.clinre.2022.101921}},
  volume       = {{46}},
  year         = {{2022}},
}