Innate lymphoid cells in atherosclerosis
(2017) In European Journal of Pharmacology 816. p.32-36- Abstract
The family of innate lymphoid cells (ILCs) consisting of NK cells, lymphoid tissue inducer cells and the 'helper'-like ILC subsets ILC1, ILC2 and ILC3 have been shown to have important roles in protection against microbes, regulation of inflammatory diseases and involved in allergic reactions. ILC1s produce IFN-γ upon stimulation with IL-12 and IL-18, ILC2s produce IL-5 and IL-13 responding to IL-33 and IL-25 while ILC3s produce IL-17 and IL-22 after stimulation with IL-23 or IL-1. Although few studies have directly investigated the role for ILCs in atherosclerosis, several studies have investigated transcription factors and cytokines shared by ILCs and T helper cells. In this review we summarize our current understanding of the role of... (More)
The family of innate lymphoid cells (ILCs) consisting of NK cells, lymphoid tissue inducer cells and the 'helper'-like ILC subsets ILC1, ILC2 and ILC3 have been shown to have important roles in protection against microbes, regulation of inflammatory diseases and involved in allergic reactions. ILC1s produce IFN-γ upon stimulation with IL-12 and IL-18, ILC2s produce IL-5 and IL-13 responding to IL-33 and IL-25 while ILC3s produce IL-17 and IL-22 after stimulation with IL-23 or IL-1. Although few studies have directly investigated the role for ILCs in atherosclerosis, several studies have investigated transcription factors and cytokines shared by ILCs and T helper cells. In this review we summarize our current understanding of the role of ILC in atherosclerosis and discuss future directions.
(Less)
- author
- Engelbertsen, Daniel LU and Lichtman, Andrew H
- publishing date
- 2017-12-05
- type
- Contribution to journal
- publication status
- published
- keywords
- Animals, Atherosclerosis/immunology, Humans, Immunity, Innate, Lymphocytes/cytology
- in
- European Journal of Pharmacology
- volume
- 816
- pages
- 5 pages
- publisher
- Elsevier
- external identifiers
-
- pmid:28449862
- scopus:85019112535
- ISSN
- 1879-0712
- DOI
- 10.1016/j.ejphar.2017.04.030
- language
- English
- LU publication?
- no
- id
- 670f69ed-9879-415a-bd5a-4f50690befd7
- date added to LUP
- 2019-01-16 10:12:09
- date last changed
- 2024-08-06 07:34:14
@article{670f69ed-9879-415a-bd5a-4f50690befd7, abstract = {{<p>The family of innate lymphoid cells (ILCs) consisting of NK cells, lymphoid tissue inducer cells and the 'helper'-like ILC subsets ILC1, ILC2 and ILC3 have been shown to have important roles in protection against microbes, regulation of inflammatory diseases and involved in allergic reactions. ILC1s produce IFN-γ upon stimulation with IL-12 and IL-18, ILC2s produce IL-5 and IL-13 responding to IL-33 and IL-25 while ILC3s produce IL-17 and IL-22 after stimulation with IL-23 or IL-1. Although few studies have directly investigated the role for ILCs in atherosclerosis, several studies have investigated transcription factors and cytokines shared by ILCs and T helper cells. In this review we summarize our current understanding of the role of ILC in atherosclerosis and discuss future directions.</p>}}, author = {{Engelbertsen, Daniel and Lichtman, Andrew H}}, issn = {{1879-0712}}, keywords = {{Animals; Atherosclerosis/immunology; Humans; Immunity, Innate; Lymphocytes/cytology}}, language = {{eng}}, month = {{12}}, pages = {{32--36}}, publisher = {{Elsevier}}, series = {{European Journal of Pharmacology}}, title = {{Innate lymphoid cells in atherosclerosis}}, url = {{http://dx.doi.org/10.1016/j.ejphar.2017.04.030}}, doi = {{10.1016/j.ejphar.2017.04.030}}, volume = {{816}}, year = {{2017}}, }