Achieving brain clearance and preventing neurodegenerative diseases—A glymphatic perspective
(2021) In Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 41(9). p.2137-2149- Abstract
- Age-related neurodegenerative diseases are a growing burden to society, and many are sporadic, meaning that the environment, diet and lifestyle play significant roles. Cerebrospinal fluid (CSF)-mediated clearing of brain waste products via perivascular pathways, named the glymphatic system, is receiving increasing interest, as it offers unexplored perspectives on understanding neurodegenerative diseases. The glymphatic system is involved in clearance of metabolic by-products such as amyloid-β from the brain, and its function is believed to lower the risk of developing some of the most common neurodegenerative diseases. Here, we present magnetic resonance imaging (MRI) data on the heart cycle’s control of CSF flow in humans which... (More)
- Age-related neurodegenerative diseases are a growing burden to society, and many are sporadic, meaning that the environment, diet and lifestyle play significant roles. Cerebrospinal fluid (CSF)-mediated clearing of brain waste products via perivascular pathways, named the glymphatic system, is receiving increasing interest, as it offers unexplored perspectives on understanding neurodegenerative diseases. The glymphatic system is involved in clearance of metabolic by-products such as amyloid-β from the brain, and its function is believed to lower the risk of developing some of the most common neurodegenerative diseases. Here, we present magnetic resonance imaging (MRI) data on the heart cycle’s control of CSF flow in humans which corroborates findings from animal studies. We also review the importance of sleep, diet, vascular health for glymphatic clearance and find that these factors are also known players in brain longevity. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/67a5633c-781c-4535-8d08-3e221632bf93
- author
- Kylkilahti, Tekla Maria
LU
; Berends, Eline
LU
; Ramos, Marta
LU
; Shanbhag, Nagesh C LU ; Töger, Johannes LU ; Bloch, Karin Markenroth LU
and Lundgaard, Iben LU
- organization
-
- Glia-Immune Interactions (research group)
- WCMM-Wallenberg Centre for Molecular Medicine
- Cancer and matrix remodelling (research group)
- Diagnostic Radiology, (Lund)
- MR Physics (research group)
- Lund Cardiac MR Group (research group)
- Clinical Physiology (Lund)
- Lund University Bioimaging Center
- MultiPark: Multidisciplinary research focused on Parkinson´s disease
- publishing date
- 2021
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
- volume
- 41
- issue
- 9
- pages
- 2137 - 2149
- publisher
- Nature Publishing Group
- external identifiers
-
- pmid:33461408
- scopus:85099686281
- ISSN
- 0271-678X
- DOI
- 10.1177/0271678X20982388
- language
- English
- LU publication?
- yes
- id
- 67a5633c-781c-4535-8d08-3e221632bf93
- date added to LUP
- 2021-01-25 11:00:51
- date last changed
- 2022-08-05 08:16:34
@article{67a5633c-781c-4535-8d08-3e221632bf93, abstract = {{Age-related neurodegenerative diseases are a growing burden to society, and many are sporadic, meaning that the environment, diet and lifestyle play significant roles. Cerebrospinal fluid (CSF)-mediated clearing of brain waste products via perivascular pathways, named the glymphatic system, is receiving increasing interest, as it offers unexplored perspectives on understanding neurodegenerative diseases. The glymphatic system is involved in clearance of metabolic by-products such as amyloid-β from the brain, and its function is believed to lower the risk of developing some of the most common neurodegenerative diseases. Here, we present magnetic resonance imaging (MRI) data on the heart cycle’s control of CSF flow in humans which corroborates findings from animal studies. We also review the importance of sleep, diet, vascular health for glymphatic clearance and find that these factors are also known players in brain longevity.}}, author = {{Kylkilahti, Tekla Maria and Berends, Eline and Ramos, Marta and Shanbhag, Nagesh C and Töger, Johannes and Bloch, Karin Markenroth and Lundgaard, Iben}}, issn = {{0271-678X}}, language = {{eng}}, number = {{9}}, pages = {{2137--2149}}, publisher = {{Nature Publishing Group}}, series = {{Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism}}, title = {{Achieving brain clearance and preventing neurodegenerative diseases—A glymphatic perspective}}, url = {{http://dx.doi.org/10.1177/0271678X20982388}}, doi = {{10.1177/0271678X20982388}}, volume = {{41}}, year = {{2021}}, }