Metabolism of chylomicron phosphatidylethanolamine in the rat
(1984) In Biochimica et Biophysica Acta 793(1). p.105-113- Abstract
- 10 min after intravenous injection of 32P-labelled chylomicrons 69% of the [32P]phosphatidylethanolamine, but only 34% of the [32P]phosphatidylcholine, was cleared from plasma. Over this time period the plasma phosphatidylethanolamine concentration that was increased after the chylomicron injection returned to normal, indicating that the rapid clearance of [32P]phosphatidylethanolamine was primarily due to metabolism and not due to exchange with tissue phospholipids. Also after chylomicron [32P]phospholipids had been transferred to high-density lipoproteins in vitro a greater fraction of [32P]phosphatidylethanolamine than of [32P]phosphatidylcholine was eliminated both in the intact rat and in the perfused rat liver. In the latter system... (More)
- 10 min after intravenous injection of 32P-labelled chylomicrons 69% of the [32P]phosphatidylethanolamine, but only 34% of the [32P]phosphatidylcholine, was cleared from plasma. Over this time period the plasma phosphatidylethanolamine concentration that was increased after the chylomicron injection returned to normal, indicating that the rapid clearance of [32P]phosphatidylethanolamine was primarily due to metabolism and not due to exchange with tissue phospholipids. Also after chylomicron [32P]phospholipids had been transferred to high-density lipoproteins in vitro a greater fraction of [32P]phosphatidylethanolamine than of [32P]phosphatidylcholine was eliminated both in the intact rat and in the perfused rat liver. In the latter system the uptake of [32P]phosphatidylethanolamine was reduced by preperfusion with heparin to remove heparin-releasable hepatic lipase. Experiments with hepatocytes and non-parenchymal liver cells, which both contain only minor amounts of surface-bound hepatic lipase, did not demonstrate any rapid uptake of [32P]phosphatidylethanolamine by exchange with cellular phospholipids. This study shows that there is a mechanism for rapid clearance of chylomicron phosphatidylethanolamine, which maintains a low plasma phosphatidylethanolamine level (30-40 micrograms/ml) despite a significant transport of phosphatidylethanolamine with the intestinal lipoproteins. A major part of the rapid phosphatidylethanolamine metabolism occurs in the liver, where the activity of the hepatic lipase is likely to be of crucial importance. (Less)
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https://lup.lub.lu.se/record/67c34fcf-5dd6-42b1-849f-8ec2b6c4db04
- author
- Landin, Britta and Nilsson, Åke LU
- publishing date
- 1984-03-01
- type
- Contribution to journal
- publication status
- published
- in
- Biochimica et Biophysica Acta
- volume
- 793
- issue
- 1
- pages
- 9 pages
- publisher
- Elsevier
- external identifiers
-
- scopus:0021343044
- ISSN
- 0006-3002
- language
- English
- LU publication?
- no
- id
- 67c34fcf-5dd6-42b1-849f-8ec2b6c4db04
- date added to LUP
- 2019-05-26 09:35:39
- date last changed
- 2021-11-22 04:00:37
@article{67c34fcf-5dd6-42b1-849f-8ec2b6c4db04,
abstract = {{10 min after intravenous injection of 32P-labelled chylomicrons 69% of the [32P]phosphatidylethanolamine, but only 34% of the [32P]phosphatidylcholine, was cleared from plasma. Over this time period the plasma phosphatidylethanolamine concentration that was increased after the chylomicron injection returned to normal, indicating that the rapid clearance of [32P]phosphatidylethanolamine was primarily due to metabolism and not due to exchange with tissue phospholipids. Also after chylomicron [32P]phospholipids had been transferred to high-density lipoproteins in vitro a greater fraction of [32P]phosphatidylethanolamine than of [32P]phosphatidylcholine was eliminated both in the intact rat and in the perfused rat liver. In the latter system the uptake of [32P]phosphatidylethanolamine was reduced by preperfusion with heparin to remove heparin-releasable hepatic lipase. Experiments with hepatocytes and non-parenchymal liver cells, which both contain only minor amounts of surface-bound hepatic lipase, did not demonstrate any rapid uptake of [32P]phosphatidylethanolamine by exchange with cellular phospholipids. This study shows that there is a mechanism for rapid clearance of chylomicron phosphatidylethanolamine, which maintains a low plasma phosphatidylethanolamine level (30-40 micrograms/ml) despite a significant transport of phosphatidylethanolamine with the intestinal lipoproteins. A major part of the rapid phosphatidylethanolamine metabolism occurs in the liver, where the activity of the hepatic lipase is likely to be of crucial importance.}},
author = {{Landin, Britta and Nilsson, Åke}},
issn = {{0006-3002}},
language = {{eng}},
month = {{03}},
number = {{1}},
pages = {{105--113}},
publisher = {{Elsevier}},
series = {{Biochimica et Biophysica Acta}},
title = {{Metabolism of chylomicron phosphatidylethanolamine in the rat}},
volume = {{793}},
year = {{1984}},
}