Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Classification of patients with knee osteoarthritis in clinical phenotypes : Data from the osteoarthritis initiative

Dell’Isola, A. LU and Steultjens, M. (2018) In PLoS ONE 13. p.1-18
Abstract

Objectives The existence of phenotypes has been hypothesized to explain the large heterogeneity characterizing the knee osteoarthritis. In a previous systematic review of the literature, six main phenotypes were identified: Minimal Joint Disease (MJD), Malaligned Biomechanical (MB), Chronic Pain (CP), Inflammatory (I), Metabolic Syndrome (MS) and Bone and Cartilage Metabolism (BCM). The purpose of this study was to classify a sample of individuals with knee osteoarthritis (KOA) into pre-defined groups characterized by specific variables that can be linked to different disease mechanisms, and compare these phenotypes for demographic and health outcomes. Methods 599 patients were selected from the OAI database FNIH at 24 months’ time to... (More)

Objectives The existence of phenotypes has been hypothesized to explain the large heterogeneity characterizing the knee osteoarthritis. In a previous systematic review of the literature, six main phenotypes were identified: Minimal Joint Disease (MJD), Malaligned Biomechanical (MB), Chronic Pain (CP), Inflammatory (I), Metabolic Syndrome (MS) and Bone and Cartilage Metabolism (BCM). The purpose of this study was to classify a sample of individuals with knee osteoarthritis (KOA) into pre-defined groups characterized by specific variables that can be linked to different disease mechanisms, and compare these phenotypes for demographic and health outcomes. Methods 599 patients were selected from the OAI database FNIH at 24 months’ time to conduct the study. For each phenotype, cut offs of key variables were identified matching the results from previous studies in the field and the data available for the sample. The selection process consisted of 3 steps. At the end of each step, the subjects classified were excluded from the further classification stages. Patients meeting the criteria for more than one phenotype were classified separately into a ‘complex KOA’ group. Results Phenotype allocation (including complex KOA) was successful for 84% of cases with an overlap of 20%. Disease duration was shorter in the MJD while the CP phenotype included a larger number of Women (81%). A significant effect of phenotypes on WOMAC pain (F = 16.736 p <0.001) and WOMAC physical function (F = 14.676, p < 0.001) was identified after controlling for disease duration. Conclusion This study signifies the feasibility of a classification of KOA subjects in distinct phenotypes based on subgroup-specific characteristics.

(Less)
Please use this url to cite or link to this publication:
author
and
publishing date
type
Contribution to journal
publication status
published
in
PLoS ONE
volume
13
article number
e0191045
pages
1 - 18
publisher
Public Library of Science (PLoS)
external identifiers
  • pmid:29329325
  • scopus:85040452313
ISSN
1932-6203
DOI
10.1371/journal.pone.0191045
language
English
LU publication?
no
additional info
Publisher Copyright: Copyright: © 2018 Dell’Isola, Steultjens. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
id
68505771-da53-44de-ae73-f8ed5c25134f
date added to LUP
2024-09-13 08:40:43
date last changed
2025-07-20 03:56:53
@article{68505771-da53-44de-ae73-f8ed5c25134f,
  abstract     = {{<p>Objectives The existence of phenotypes has been hypothesized to explain the large heterogeneity characterizing the knee osteoarthritis. In a previous systematic review of the literature, six main phenotypes were identified: Minimal Joint Disease (MJD), Malaligned Biomechanical (MB), Chronic Pain (CP), Inflammatory (I), Metabolic Syndrome (MS) and Bone and Cartilage Metabolism (BCM). The purpose of this study was to classify a sample of individuals with knee osteoarthritis (KOA) into pre-defined groups characterized by specific variables that can be linked to different disease mechanisms, and compare these phenotypes for demographic and health outcomes. Methods 599 patients were selected from the OAI database FNIH at 24 months’ time to conduct the study. For each phenotype, cut offs of key variables were identified matching the results from previous studies in the field and the data available for the sample. The selection process consisted of 3 steps. At the end of each step, the subjects classified were excluded from the further classification stages. Patients meeting the criteria for more than one phenotype were classified separately into a ‘complex KOA’ group. Results Phenotype allocation (including complex KOA) was successful for 84% of cases with an overlap of 20%. Disease duration was shorter in the MJD while the CP phenotype included a larger number of Women (81%). A significant effect of phenotypes on WOMAC pain (F = 16.736 p &lt;0.001) and WOMAC physical function (F = 14.676, p &lt; 0.001) was identified after controlling for disease duration. Conclusion This study signifies the feasibility of a classification of KOA subjects in distinct phenotypes based on subgroup-specific characteristics.</p>}},
  author       = {{Dell’Isola, A. and Steultjens, M.}},
  issn         = {{1932-6203}},
  language     = {{eng}},
  pages        = {{1--18}},
  publisher    = {{Public Library of Science (PLoS)}},
  series       = {{PLoS ONE}},
  title        = {{Classification of patients with knee osteoarthritis in clinical phenotypes : Data from the osteoarthritis initiative}},
  url          = {{http://dx.doi.org/10.1371/journal.pone.0191045}},
  doi          = {{10.1371/journal.pone.0191045}},
  volume       = {{13}},
  year         = {{2018}},
}