Risk Factors and Outcomes of Acute Kidney Injury After Cardiac Surgery : A Retrospective Observational Single-Center Study
(2024) In Journal of clinical medicine research 16(7-8). p.375-380- Abstract
BACKGROUND: Acute kidney injury (AKI) following cardiac surgery is a well-described phenomenon, usually associated with hemodynamic changes ultimately leading to ischemic injury to the kidneys. In this study, we assessed the occurrence of AKI in a cohort of patients undergoing elective cardiac surgery at a single center.
METHODS: Patients undergoing elective cardiac surgery (coronary artery bypass grafting (CABG) and/or valve repair) between the years 2016 and 2022 were retrospectively included in the study.
RESULTS: During the study, 167 patients underwent CABG, valve replacement, or both procedures. The majority were male (85.0%). Post-operative AKI was observed in 27.5% of patients, with 2.4% requiring continuous renal... (More)
BACKGROUND: Acute kidney injury (AKI) following cardiac surgery is a well-described phenomenon, usually associated with hemodynamic changes ultimately leading to ischemic injury to the kidneys. In this study, we assessed the occurrence of AKI in a cohort of patients undergoing elective cardiac surgery at a single center.
METHODS: Patients undergoing elective cardiac surgery (coronary artery bypass grafting (CABG) and/or valve repair) between the years 2016 and 2022 were retrospectively included in the study.
RESULTS: During the study, 167 patients underwent CABG, valve replacement, or both procedures. The majority were male (85.0%). Post-operative AKI was observed in 27.5% of patients, with 2.4% requiring continuous renal replacement therapy (CRRT)/dialysis. The majority of AKI cases were staged as Kidney Disease: Improving Global Outcomes (KDIGO) stage 1. Among patients needing CRRT/dialysis, 1.8% recovered renal function within 3 months, with 0.6% experiencing 30-day mortality. In univariate analysis, factors associated with AKI included older age (P = 0.003), severe anemia (P < 0.0001), pre-operative creatinine elevation (P < 0.0001), complex surgeries (P < 0.0001), blood product transfusion (P < 0.0001), longer cross-clamp (XC) and cardiopulmonary bypass (CPB) times (P < 0.0001), and inotropes usage (P < 0.0001). Classical risk factors like diabetes mellitus (DM) and hypertension did not show significant differences. The majority of these factors (severe anemia, age, pre-operative creatinine, post-operative inotrope usage, and cross-clamp times) were consistently significant (P < 0.05) in logistic regression analysis.
CONCLUSION: Post-operative AKI following cardiac surgery is frequent, with significant associations seen especially with pre-operative anemia. Future investigations focusing on the specific causes of anemia linked to AKI development are essential, considering the high prevalence of hemoglobinopathy traits in our population.
(Less)
- author
- organization
- publishing date
- 2024-08
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of clinical medicine research
- volume
- 16
- issue
- 7-8
- pages
- 375 - 380
- publisher
- Elmer Press
- external identifiers
-
- pmid:39206102
- scopus:85210002567
- ISSN
- 1918-3003
- DOI
- 10.14740/jocmr5220
- language
- English
- LU publication?
- yes
- additional info
- Copyright 2024, Mohrag et al.
- id
- 68a15162-ba8a-44c5-a5fb-6bcfc3084f13
- date added to LUP
- 2024-10-15 18:44:09
- date last changed
- 2025-05-15 21:16:31
@article{68a15162-ba8a-44c5-a5fb-6bcfc3084f13,
abstract = {{<p>BACKGROUND: Acute kidney injury (AKI) following cardiac surgery is a well-described phenomenon, usually associated with hemodynamic changes ultimately leading to ischemic injury to the kidneys. In this study, we assessed the occurrence of AKI in a cohort of patients undergoing elective cardiac surgery at a single center.</p><p>METHODS: Patients undergoing elective cardiac surgery (coronary artery bypass grafting (CABG) and/or valve repair) between the years 2016 and 2022 were retrospectively included in the study.</p><p>RESULTS: During the study, 167 patients underwent CABG, valve replacement, or both procedures. The majority were male (85.0%). Post-operative AKI was observed in 27.5% of patients, with 2.4% requiring continuous renal replacement therapy (CRRT)/dialysis. The majority of AKI cases were staged as Kidney Disease: Improving Global Outcomes (KDIGO) stage 1. Among patients needing CRRT/dialysis, 1.8% recovered renal function within 3 months, with 0.6% experiencing 30-day mortality. In univariate analysis, factors associated with AKI included older age (P = 0.003), severe anemia (P < 0.0001), pre-operative creatinine elevation (P < 0.0001), complex surgeries (P < 0.0001), blood product transfusion (P < 0.0001), longer cross-clamp (XC) and cardiopulmonary bypass (CPB) times (P < 0.0001), and inotropes usage (P < 0.0001). Classical risk factors like diabetes mellitus (DM) and hypertension did not show significant differences. The majority of these factors (severe anemia, age, pre-operative creatinine, post-operative inotrope usage, and cross-clamp times) were consistently significant (P < 0.05) in logistic regression analysis.</p><p>CONCLUSION: Post-operative AKI following cardiac surgery is frequent, with significant associations seen especially with pre-operative anemia. Future investigations focusing on the specific causes of anemia linked to AKI development are essential, considering the high prevalence of hemoglobinopathy traits in our population.</p>}},
author = {{Mohrag, Mostafa and Abdulrasak, Mohammed and Borik, Waseem and Alshamakhi, Atheer and Ageeli, Nada and Abu Allah, Roaa and Al Hammadah, Maryam and Saabi, Somaya and Moafa, Reema and Darraj, Atheer and Farasani, Moath and Oraibi, Omar and Somaili, Mohammed and Madkhali, Mohammed Ali and Alqassmi, Sameer and Someili, Ali}},
issn = {{1918-3003}},
language = {{eng}},
number = {{7-8}},
pages = {{375--380}},
publisher = {{Elmer Press}},
series = {{Journal of clinical medicine research}},
title = {{Risk Factors and Outcomes of Acute Kidney Injury After Cardiac Surgery : A Retrospective Observational Single-Center Study}},
url = {{http://dx.doi.org/10.14740/jocmr5220}},
doi = {{10.14740/jocmr5220}},
volume = {{16}},
year = {{2024}},
}