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Bioinformatic approaches for modeling the substrate specificity of HIV-1 protease: an overview

Rognvaldsson, Thorsteinn ; You, Liwen LU and Garwicz, Daniel LU (2007) In Expert Review of Molecular Diagnostics 7(4). p.435-451
Abstract
HIV-1 protease has a broad and complex substrate specificity, which hitherto has escaped a simple comprehensive definition. This, and the relatively high mutation rate of the retroviral protease, makes it challenging to design effective protease inhibitors. Several attempts have been made during the last two decades to elucidate the enigmatic cleavage specificity of HIV-1 protease and to predict cleavage of novel substrates using bioinformatic analysis methods. This review describes the methods that have been utilized to date to address this important problem and the results achieved. The data sets used are also reviewed and important aspects of these are highlighted.
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author
; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
protease, prediction, human immunodeficiency virus, HIV, bioinformatics, cleavage rule, physicochemical property
in
Expert Review of Molecular Diagnostics
volume
7
issue
4
pages
435 - 451
publisher
Future Drugs Ltd
external identifiers
  • wos:000248620700010
  • scopus:34447517453
ISSN
1744-8352
DOI
10.1586/14737159.7.4.435
language
English
LU publication?
yes
id
d1cb555e-a759-4bde-b97b-3e45ff91f210 (old id 691969)
date added to LUP
2016-04-01 11:37:09
date last changed
2024-10-08 03:28:30
@article{d1cb555e-a759-4bde-b97b-3e45ff91f210,
  abstract     = {{HIV-1 protease has a broad and complex substrate specificity, which hitherto has escaped a simple comprehensive definition. This, and the relatively high mutation rate of the retroviral protease, makes it challenging to design effective protease inhibitors. Several attempts have been made during the last two decades to elucidate the enigmatic cleavage specificity of HIV-1 protease and to predict cleavage of novel substrates using bioinformatic analysis methods. This review describes the methods that have been utilized to date to address this important problem and the results achieved. The data sets used are also reviewed and important aspects of these are highlighted.}},
  author       = {{Rognvaldsson, Thorsteinn and You, Liwen and Garwicz, Daniel}},
  issn         = {{1744-8352}},
  keywords     = {{protease; prediction; human immunodeficiency virus; HIV; bioinformatics; cleavage rule; physicochemical property}},
  language     = {{eng}},
  number       = {{4}},
  pages        = {{435--451}},
  publisher    = {{Future Drugs Ltd}},
  series       = {{Expert Review of Molecular Diagnostics}},
  title        = {{Bioinformatic approaches for modeling the substrate specificity of HIV-1 protease: an overview}},
  url          = {{http://dx.doi.org/10.1586/14737159.7.4.435}},
  doi          = {{10.1586/14737159.7.4.435}},
  volume       = {{7}},
  year         = {{2007}},
}