Effect of temperature on the association behavior in aqueous mixtures of an oppositely charged amphiphilic block copolymer and bile salt
(2020) In Polymer 206.- Abstract
The association in aqueous mixtures of a thermoresponsive cationic diblock copolymer composed of poly(N-isopropylacrylamide) (PNIPAM) and poly(3-acrylamidopropyl)-trimethylammonium-chloride (PAMPTMA(+)) and the oppositely charged bile salt sodium deoxycholate (NaDC) is investigated at different compositions by light and X-ray scattering, calorimetry, and electrophoretic mobility measurements. Clouding reveals aggregation upon heating. The addition of NaDC to the copolymer solution lowers the temperature of the transition and increases its cooperativity. At high temperature and low NaDC fractions, mixed aggregates with a dehydrated PNIPAM-rich interior and a PAMPTMA(+)-rich shell partially neutralized by DC– anions are formed.... (More)
The association in aqueous mixtures of a thermoresponsive cationic diblock copolymer composed of poly(N-isopropylacrylamide) (PNIPAM) and poly(3-acrylamidopropyl)-trimethylammonium-chloride (PAMPTMA(+)) and the oppositely charged bile salt sodium deoxycholate (NaDC) is investigated at different compositions by light and X-ray scattering, calorimetry, and electrophoretic mobility measurements. Clouding reveals aggregation upon heating. The addition of NaDC to the copolymer solution lowers the temperature of the transition and increases its cooperativity. At high temperature and low NaDC fractions, mixed aggregates with a dehydrated PNIPAM-rich interior and a PAMPTMA(+)-rich shell partially neutralized by DC– anions are formed. At high NaDC fractions, the aggregates present internal regularly spaced segregated nanoregions of dehydrated PNIPAM and PAMPTMA(+)/DC– (microphase separation). The results suggest that the mixed aggregates have appealing composition-controlled thermoresponse. The system phase separates at body temperature and the highest NaDC fractions investigated, meaning in conditions accomplished when the use of the polymer as a bile salt sequestrant is hypothesized.
(Less)
- author
- Du, Guanqun LU ; Del Giudice, Alessandra LU ; Alfredsson, Viveka LU ; Carnerup, Anna M. LU ; Pavel, Nicolae V. ; Loh, Watson LU ; Masci, Giancarlo ; Nyström, Bo ; Galantini, Luciano and Schillén, Karin LU
- organization
- publishing date
- 2020
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Bile salts, Cationic thermoresponsive block copolymers, Oppositely charged polymer-surfactant systems
- in
- Polymer
- volume
- 206
- article number
- 122871
- publisher
- Elsevier
- external identifiers
-
- scopus:85090129803
- ISSN
- 0032-3861
- DOI
- 10.1016/j.polymer.2020.122871
- language
- English
- LU publication?
- yes
- id
- 695e48b7-8003-4738-8657-73c264e4d0f2
- date added to LUP
- 2020-09-14 13:58:25
- date last changed
- 2022-04-19 00:44:37
@article{695e48b7-8003-4738-8657-73c264e4d0f2, abstract = {{<p>The association in aqueous mixtures of a thermoresponsive cationic diblock copolymer composed of poly(N-isopropylacrylamide) (PNIPAM) and poly(3-acrylamidopropyl)-trimethylammonium-chloride (PAMPTMA(+)) and the oppositely charged bile salt sodium deoxycholate (NaDC) is investigated at different compositions by light and X-ray scattering, calorimetry, and electrophoretic mobility measurements. Clouding reveals aggregation upon heating. The addition of NaDC to the copolymer solution lowers the temperature of the transition and increases its cooperativity. At high temperature and low NaDC fractions, mixed aggregates with a dehydrated PNIPAM-rich interior and a PAMPTMA(+)-rich shell partially neutralized by DC<sup>–</sup> anions are formed. At high NaDC fractions, the aggregates present internal regularly spaced segregated nanoregions of dehydrated PNIPAM and PAMPTMA(+)/DC<sup>–</sup> (microphase separation). The results suggest that the mixed aggregates have appealing composition-controlled thermoresponse. The system phase separates at body temperature and the highest NaDC fractions investigated, meaning in conditions accomplished when the use of the polymer as a bile salt sequestrant is hypothesized.</p>}}, author = {{Du, Guanqun and Del Giudice, Alessandra and Alfredsson, Viveka and Carnerup, Anna M. and Pavel, Nicolae V. and Loh, Watson and Masci, Giancarlo and Nyström, Bo and Galantini, Luciano and Schillén, Karin}}, issn = {{0032-3861}}, keywords = {{Bile salts; Cationic thermoresponsive block copolymers; Oppositely charged polymer-surfactant systems}}, language = {{eng}}, publisher = {{Elsevier}}, series = {{Polymer}}, title = {{Effect of temperature on the association behavior in aqueous mixtures of an oppositely charged amphiphilic block copolymer and bile salt}}, url = {{http://dx.doi.org/10.1016/j.polymer.2020.122871}}, doi = {{10.1016/j.polymer.2020.122871}}, volume = {{206}}, year = {{2020}}, }