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CADET-Hub: Online platform for biomanufacturing modeling and stability testing

Lanzrath, Hannah ; Li, Xiyan ; Bracewell, Daniel G. ; Calvosa, Eric ; Cardillo, Antonio Gaetano ; Clenet, Didier ; Espinoza, Daniel LU ; Forestieri, Caroline ; Gernaey, Krist V. and Gomis Fons, Joaquín LU , et al. (2026) In Computers & Chemical Engineering 212.
Abstract
Biomanufacturing increasingly relies on computational modeling to strengthen process understanding, speed up process development, scale-up and scale-down, improve experimental design, and reduce reliance on costly and laborious wet lab activities. Here we present CADET-Hub, a modular web-based platform for biomanufacturing and stability modeling, developed within the Inno4Vac project. CADET-Hub unifies upstream and downstream bioprocess modeling with stability prediction in a single, user accessible environment. The upstream modules comprise compartment models derived from computational fluid dynamics and metabolic models for bioreactor simulation. The downstream modules cover centrifugation, filtration, and chromatography, implemented... (More)
Biomanufacturing increasingly relies on computational modeling to strengthen process understanding, speed up process development, scale-up and scale-down, improve experimental design, and reduce reliance on costly and laborious wet lab activities. Here we present CADET-Hub, a modular web-based platform for biomanufacturing and stability modeling, developed within the Inno4Vac project. CADET-Hub unifies upstream and downstream bioprocess modeling with stability prediction in a single, user accessible environment. The upstream modules comprise compartment models derived from computational fluid dynamics and metabolic models for bioreactor simulation. The downstream modules cover centrifugation, filtration, and chromatography, implemented through the open-source bioprocess simulation engine CADET-Core and its workflow and model-building layer CADET-Process. A dedicated stability forecasting module completes the platform by enabling shelf life prediction of biological products using advanced kinetic and statistical methods. Throughout the project, we engaged with regulatory bodies to inform model development, validation, and documentation in line with current regulatory expectations for biopharmaceutical applications. (Less)
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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Computers & Chemical Engineering
volume
212
article number
109690
pages
18 pages
publisher
Elsevier
external identifiers
  • scopus:105039129884
ISSN
1873-4375
DOI
10.1016/j.compchemeng.2026.109690
language
English
LU publication?
yes
id
69c348ef-cfaf-450a-9246-646c1829016b
date added to LUP
2026-05-20 09:41:02
date last changed
2026-06-08 04:01:15
@article{69c348ef-cfaf-450a-9246-646c1829016b,
  abstract     = {{Biomanufacturing increasingly relies on computational modeling to strengthen process understanding, speed up process development, scale-up and scale-down, improve experimental design, and reduce reliance on costly and laborious wet lab activities. Here we present CADET-Hub, a modular web-based platform for biomanufacturing and stability modeling, developed within the Inno4Vac project. CADET-Hub unifies upstream and downstream bioprocess modeling with stability prediction in a single, user accessible environment. The upstream modules comprise compartment models derived from computational fluid dynamics and metabolic models for bioreactor simulation. The downstream modules cover centrifugation, filtration, and chromatography, implemented through the open-source bioprocess simulation engine CADET-Core and its workflow and model-building layer CADET-Process. A dedicated stability forecasting module completes the platform by enabling shelf life prediction of biological products using advanced kinetic and statistical methods. Throughout the project, we engaged with regulatory bodies to inform model development, validation, and documentation in line with current regulatory expectations for biopharmaceutical applications.}},
  author       = {{Lanzrath, Hannah and Li, Xiyan and Bracewell, Daniel G. and Calvosa, Eric and Cardillo, Antonio Gaetano and Clenet, Didier and Espinoza, Daniel and Forestieri, Caroline and Gernaey, Krist V. and Gomis Fons, Joaquín and Hørsholt, Steen and Bagterp Jørgensen, John and Lebrun, Pierre and Mansois, Noemie and Martin, William and Meln, Irina and Van Molle, Wim and Natalis, Laurent and Nilsson, Bernt and Perea-Vélez, Mónica and Rayat, Andrea C.M.E. and Rother, Dörte and Schmölder, Johannes and Liebers, Reinhard and von Lieres, Eric}},
  issn         = {{1873-4375}},
  language     = {{eng}},
  publisher    = {{Elsevier}},
  series       = {{Computers & Chemical Engineering}},
  title        = {{CADET-Hub: Online platform for biomanufacturing modeling and stability testing}},
  url          = {{http://dx.doi.org/10.1016/j.compchemeng.2026.109690}},
  doi          = {{10.1016/j.compchemeng.2026.109690}},
  volume       = {{212}},
  year         = {{2026}},
}