The Genetics of Urinary Tract Infections and the Innate Defense of the Kidney and Urinary tract
(2016) In Journal of pediatric genetics 5(1). p.25-32- Abstract
The urinary tract is a sterile organ system. Urinary tract infections (UTIs) are common and often serious infections. Research has focused on uropathogen, environment, and host factors leading to UTI pathogenesis. A growing body of evidence exists implicating genetic factors that can contribute to UTI risks. In this review, we highlight genetic variations in aspects of the innate immune system critical to the host response to uropathogens. This overview includes genetic variations in pattern recognition receptor molecules, chemokines/cytokines, and neutrophil activation. We also comprehensively cover murine knockout models of UTI, genetic variations involved in renal scarring as a result of ascending UTIs, and asymptomatic bacteriuria.... (More)
The urinary tract is a sterile organ system. Urinary tract infections (UTIs) are common and often serious infections. Research has focused on uropathogen, environment, and host factors leading to UTI pathogenesis. A growing body of evidence exists implicating genetic factors that can contribute to UTI risks. In this review, we highlight genetic variations in aspects of the innate immune system critical to the host response to uropathogens. This overview includes genetic variations in pattern recognition receptor molecules, chemokines/cytokines, and neutrophil activation. We also comprehensively cover murine knockout models of UTI, genetic variations involved in renal scarring as a result of ascending UTIs, and asymptomatic bacteriuria.
(Less)
- author
- Ambite, Ines LU ; RYDSTRÖM, GUSTAV LU ; Schwaderer, Andrew L and Hains, David S
- organization
- publishing date
- 2016-03
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Journal Article, Review
- in
- Journal of pediatric genetics
- volume
- 5
- issue
- 1
- pages
- 25 - 32
- publisher
- Georg Thieme Verlag
- external identifiers
-
- pmid:27617139
- ISSN
- 2146-4596
- DOI
- 10.1055/s-0035-1557110
- language
- English
- LU publication?
- yes
- id
- 6aacfe2a-07dc-451c-a891-7706356d2723
- date added to LUP
- 2018-05-17 17:00:28
- date last changed
- 2018-11-21 21:39:53
@article{6aacfe2a-07dc-451c-a891-7706356d2723, abstract = {{<p>The urinary tract is a sterile organ system. Urinary tract infections (UTIs) are common and often serious infections. Research has focused on uropathogen, environment, and host factors leading to UTI pathogenesis. A growing body of evidence exists implicating genetic factors that can contribute to UTI risks. In this review, we highlight genetic variations in aspects of the innate immune system critical to the host response to uropathogens. This overview includes genetic variations in pattern recognition receptor molecules, chemokines/cytokines, and neutrophil activation. We also comprehensively cover murine knockout models of UTI, genetic variations involved in renal scarring as a result of ascending UTIs, and asymptomatic bacteriuria. </p>}}, author = {{Ambite, Ines and RYDSTRÖM, GUSTAV and Schwaderer, Andrew L and Hains, David S}}, issn = {{2146-4596}}, keywords = {{Journal Article; Review}}, language = {{eng}}, number = {{1}}, pages = {{25--32}}, publisher = {{Georg Thieme Verlag}}, series = {{Journal of pediatric genetics}}, title = {{The Genetics of Urinary Tract Infections and the Innate Defense of the Kidney and Urinary tract}}, url = {{http://dx.doi.org/10.1055/s-0035-1557110}}, doi = {{10.1055/s-0035-1557110}}, volume = {{5}}, year = {{2016}}, }