Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Fibronectin-guided migration of carcinoma collectives

Gopal, Sandeep LU orcid ; Veracini, Laurence ; Grall, Dominique ; Butori, Catherine ; Schaub, Sébastien ; Audebert, Stéphane ; Camoin, Luc ; Baudelet, Emilie ; Radwanska, Agata and Beghelli-de la Forest Divonne, Stéphanie , et al. (2017) In Nature Communications 8. p.1-15
Abstract

Functional interplay between tumour cells and their neoplastic extracellular matrix plays a decisive role in malignant progression of carcinomas. Here we provide a comprehensive data set of the human HNSCC-associated fibroblast matrisome. Although much attention has been paid to the deposit of collagen, we identify oncofetal fibronectin (FN) as a major and obligate component of the matrix assembled by stromal fibroblasts from head and neck squamous cell carcinomas (HNSCC). FN overexpression in tumours from 435 patients corresponds to an independent unfavourable prognostic indicator. We show that migration of carcinoma collectives on fibrillar FN-rich matrices is achieved through αvβ6 and α9β1 engagement, rather than α5β1. Moreover,... (More)

Functional interplay between tumour cells and their neoplastic extracellular matrix plays a decisive role in malignant progression of carcinomas. Here we provide a comprehensive data set of the human HNSCC-associated fibroblast matrisome. Although much attention has been paid to the deposit of collagen, we identify oncofetal fibronectin (FN) as a major and obligate component of the matrix assembled by stromal fibroblasts from head and neck squamous cell carcinomas (HNSCC). FN overexpression in tumours from 435 patients corresponds to an independent unfavourable prognostic indicator. We show that migration of carcinoma collectives on fibrillar FN-rich matrices is achieved through αvβ6 and α9β1 engagement, rather than α5β1. Moreover, αvβ6-driven migration occurs independently of latent TGF-β activation and Smad-dependent signalling in tumour epithelial cells. These results provide insights into the adhesion-dependent events at the tumour-stroma interface that govern the collective mode of migration adopted by carcinoma cells to invade surrounding stroma in HNSCC.

(Less)
Please use this url to cite or link to this publication:
author
; ; ; ; ; ; ; ; and , et al. (More)
; ; ; ; ; ; ; ; ; ; ; ; ; ; ; and (Less)
publishing date
type
Contribution to journal
publication status
published
keywords
Adult, Aged, Aged, 80 and over, Carcinoma, Squamous Cell, Cell Line, Tumor, Cell Movement/drug effects, Extracellular Matrix, Female, Fibronectins/metabolism, Gene Expression Regulation, Neoplastic, Head and Neck Neoplasms, Humans, Integrins/genetics, Male, Middle Aged, Squamous Cell Carcinoma of Head and Neck
in
Nature Communications
volume
8
article number
14105
pages
1 - 15
publisher
Nature Publishing Group
external identifiers
  • pmid:28102238
  • scopus:85010424342
ISSN
2041-1723
DOI
10.1038/ncomms14105
language
English
LU publication?
no
id
6b61c408-8494-4ae1-afc0-6d35706cd48d
date added to LUP
2021-10-25 13:10:31
date last changed
2024-06-16 22:08:12
@article{6b61c408-8494-4ae1-afc0-6d35706cd48d,
  abstract     = {{<p>Functional interplay between tumour cells and their neoplastic extracellular matrix plays a decisive role in malignant progression of carcinomas. Here we provide a comprehensive data set of the human HNSCC-associated fibroblast matrisome. Although much attention has been paid to the deposit of collagen, we identify oncofetal fibronectin (FN) as a major and obligate component of the matrix assembled by stromal fibroblasts from head and neck squamous cell carcinomas (HNSCC). FN overexpression in tumours from 435 patients corresponds to an independent unfavourable prognostic indicator. We show that migration of carcinoma collectives on fibrillar FN-rich matrices is achieved through αvβ6 and α9β1 engagement, rather than α5β1. Moreover, αvβ6-driven migration occurs independently of latent TGF-β activation and Smad-dependent signalling in tumour epithelial cells. These results provide insights into the adhesion-dependent events at the tumour-stroma interface that govern the collective mode of migration adopted by carcinoma cells to invade surrounding stroma in HNSCC.</p>}},
  author       = {{Gopal, Sandeep and Veracini, Laurence and Grall, Dominique and Butori, Catherine and Schaub, Sébastien and Audebert, Stéphane and Camoin, Luc and Baudelet, Emilie and Radwanska, Agata and Beghelli-de la Forest Divonne, Stéphanie and Violette, Shelia M and Weinreb, Paul H and Rekima, Samah and Ilie, Marius and Sudaka, Anne and Hofman, Paul and Van Obberghen-Schilling, Ellen}},
  issn         = {{2041-1723}},
  keywords     = {{Adult; Aged; Aged, 80 and over; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Movement/drug effects; Extracellular Matrix; Female; Fibronectins/metabolism; Gene Expression Regulation, Neoplastic; Head and Neck Neoplasms; Humans; Integrins/genetics; Male; Middle Aged; Squamous Cell Carcinoma of Head and Neck}},
  language     = {{eng}},
  pages        = {{1--15}},
  publisher    = {{Nature Publishing Group}},
  series       = {{Nature Communications}},
  title        = {{Fibronectin-guided migration of carcinoma collectives}},
  url          = {{http://dx.doi.org/10.1038/ncomms14105}},
  doi          = {{10.1038/ncomms14105}},
  volume       = {{8}},
  year         = {{2017}},
}