Seasonal influenza vaccine effectiveness against influenza in 2012-2013 : A hospital-based case-control study in Lithuania
(2014) In Vaccine 32(7). p.857-863- Abstract
Background: Due to scarce information on seasonal influenza vaccine effectiveness (SIVE) against severe clinical influenza outcomes in risk populations, we conducted a case-control study to assess its effects against laboratory-confirmed influenza in hospitalized patients during the 2012-2013 influenza season. Methods: We conducted a test-negative case-control study among ≥18 years old patients with influenza-like illness (ILI) hospitalized in two Lithuanian hospitals. Cases were influenza A(H1N1), A(H3) or influenza B positive by RT-PCR, and controls were influenza negative. Additional demographic and clinical data to assess the role of confounding were collected. SIVE and its confidence intervals (95% CI) were estimated by using... (More)
Background: Due to scarce information on seasonal influenza vaccine effectiveness (SIVE) against severe clinical influenza outcomes in risk populations, we conducted a case-control study to assess its effects against laboratory-confirmed influenza in hospitalized patients during the 2012-2013 influenza season. Methods: We conducted a test-negative case-control study among ≥18 years old patients with influenza-like illness (ILI) hospitalized in two Lithuanian hospitals. Cases were influenza A(H1N1), A(H3) or influenza B positive by RT-PCR, and controls were influenza negative. Additional demographic and clinical data to assess the role of confounding were collected. SIVE and its confidence intervals (95% CI) were estimated by using multivariate logistic regression as (1. OR). ×. 100%. Results: The sample consisted of 185 subjects. Seasonal influenza vaccine uptake was 5%. Among 111 (60%) influenza positive cases, 24.3% were A(H1N1), 10.8% were A(H3) and 24.3% were influenza B cases. Unadjusted SIVE was 79% (95% CI -6% to 96%) and after the adjustment it increased to 86% (95% CI 19% to 97%). Conclusions: Seasonal influenza vaccination in 2012-2013 was associated with reduced occurrence of laboratory-confirmed influenza, but due to low sample size the estimate of SIVE is imprecise. Given high prevalence of influenza in hospitalized ILI cases and low influenza vaccination coverage, there is a need to increase influenza vaccination rates.
(Less)
- author
- publishing date
- 2014-02-07
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Case-control studies, Effectiveness, Influenza, Influenza vaccine, Lithuania
- in
- Vaccine
- volume
- 32
- issue
- 7
- pages
- 857 - 863
- publisher
- Elsevier
- external identifiers
-
- pmid:24370711
- scopus:84892857429
- ISSN
- 0264-410X
- DOI
- 10.1016/j.vaccine.2013.12.021
- project
- Newly introduced vaccines: effectiveness and determinants of acceptance
- Infectious diseases surveillance, vaccine effectiveness and determinants of acceptance
- language
- English
- LU publication?
- no
- id
- 6b6de864-82bf-42da-bb00-c8c020486744
- date added to LUP
- 2020-05-14 14:30:53
- date last changed
- 2024-05-01 11:00:24
@article{6b6de864-82bf-42da-bb00-c8c020486744, abstract = {{<p>Background: Due to scarce information on seasonal influenza vaccine effectiveness (SIVE) against severe clinical influenza outcomes in risk populations, we conducted a case-control study to assess its effects against laboratory-confirmed influenza in hospitalized patients during the 2012-2013 influenza season. Methods: We conducted a test-negative case-control study among ≥18 years old patients with influenza-like illness (ILI) hospitalized in two Lithuanian hospitals. Cases were influenza A(H1N1), A(H3) or influenza B positive by RT-PCR, and controls were influenza negative. Additional demographic and clinical data to assess the role of confounding were collected. SIVE and its confidence intervals (95% CI) were estimated by using multivariate logistic regression as (1. OR). ×. 100%. Results: The sample consisted of 185 subjects. Seasonal influenza vaccine uptake was 5%. Among 111 (60%) influenza positive cases, 24.3% were A(H1N1), 10.8% were A(H3) and 24.3% were influenza B cases. Unadjusted SIVE was 79% (95% CI -6% to 96%) and after the adjustment it increased to 86% (95% CI 19% to 97%). Conclusions: Seasonal influenza vaccination in 2012-2013 was associated with reduced occurrence of laboratory-confirmed influenza, but due to low sample size the estimate of SIVE is imprecise. Given high prevalence of influenza in hospitalized ILI cases and low influenza vaccination coverage, there is a need to increase influenza vaccination rates.</p>}}, author = {{Gefenaite, Giedre and Rahamat-Langendoen, Janette and Ambrozaitis, Arvydas and Mickiene, Aukse and Jancoriene, Ligita and Kuliese, Monika and Velyvyte, Daiva and Niesters, Hubert and Stolk, Ronald P. and Zagminas, Kestutis and Hak, Eelko}}, issn = {{0264-410X}}, keywords = {{Case-control studies; Effectiveness; Influenza; Influenza vaccine; Lithuania}}, language = {{eng}}, month = {{02}}, number = {{7}}, pages = {{857--863}}, publisher = {{Elsevier}}, series = {{Vaccine}}, title = {{Seasonal influenza vaccine effectiveness against influenza in 2012-2013 : A hospital-based case-control study in Lithuania}}, url = {{http://dx.doi.org/10.1016/j.vaccine.2013.12.021}}, doi = {{10.1016/j.vaccine.2013.12.021}}, volume = {{32}}, year = {{2014}}, }