Putaminal T1/T2-weighted ratio is increased in PSP compared to PD and healthy controls, a multi-cohort study
(2024) In Parkinsonism and Related Disorders 121.- Abstract
Introduction: Differentiating Parkinson's disease (PD) from progressive supranuclear palsy (PSP) and multiple system atrophy (MSA) is a common clinical problem. We aimed to apply the T1-/T2-weighted ratio imaging technique, based on standard clinical MRI, to reveal differences in neurodegeneration in three large cohorts. Methods: Three cohorts, with a total of 405 participants (269 PD, 44 PSP, 38 MSA, 54 controls), were combined and T1/T2-weighted ratio image analyses were carried out. A combination of automatic segmentation and atlas-based ROI were used in this study. The cohorts were combined using the ComBat batch correction procedure. Results: Group differences were found in the putamen (p... (More)
Introduction: Differentiating Parkinson's disease (PD) from progressive supranuclear palsy (PSP) and multiple system atrophy (MSA) is a common clinical problem. We aimed to apply the T1-/T2-weighted ratio imaging technique, based on standard clinical MRI, to reveal differences in neurodegeneration in three large cohorts. Methods: Three cohorts, with a total of 405 participants (269 PD, 44 PSP, 38 MSA, 54 controls), were combined and T1/T2-weighted ratio image analyses were carried out. A combination of automatic segmentation and atlas-based ROI were used in this study. The cohorts were combined using the ComBat batch correction procedure. Results: Group differences were found in the putamen (p = 0.040), with higher T1/T2-weighted ratio in this region in PSP compared to PD and healthy controls (p-values 0.010 and 0.007 respectively). Using putaminal T1/T2-weighted ratio for diagnostic separation, a fair performance was found in separating PSP from healthy controls, with an area under the receiver operating characteristic curve of 0.701. Conclusion: Different patterns of T1/T2-weighted ratio, reflecting differences in underlying pathophysiology, were found between the groups. Since T1/T2-weighted ratio can be applied to standard clinical MRI sequences to allow more quantitative analyses, this seems to be a promising biomarker for diagnostics and treatment evaluation of parkinsonian disorders for clinical trials.
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- author
- Sjöström, Henrik ; van Westen, Danielle LU ; Hall, Sara LU ; Tjerkaski, Jonathan ; Westman, Eric ; Muehlboeck, Sebastian ; Hansson, Oskar LU ; Svenningsson, Per and Granberg, Tobias
- organization
- publishing date
- 2024
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Parkinsonism and Related Disorders
- volume
- 121
- article number
- 106047
- publisher
- Elsevier
- external identifiers
-
- pmid:38368753
- scopus:85185529185
- ISSN
- 1353-8020
- DOI
- 10.1016/j.parkreldis.2024.106047
- language
- English
- LU publication?
- yes
- id
- 6d9cffa1-77fe-428f-9200-c5a4a01154a5
- date added to LUP
- 2024-03-14 12:36:42
- date last changed
- 2024-06-20 14:25:47
@article{6d9cffa1-77fe-428f-9200-c5a4a01154a5, abstract = {{<p>Introduction: Differentiating Parkinson's disease (PD) from progressive supranuclear palsy (PSP) and multiple system atrophy (MSA) is a common clinical problem. We aimed to apply the T<sub>1</sub>-/T<sub>2</sub>-weighted ratio imaging technique, based on standard clinical MRI, to reveal differences in neurodegeneration in three large cohorts. Methods: Three cohorts, with a total of 405 participants (269 PD, 44 PSP, 38 MSA, 54 controls), were combined and T<sub>1</sub>/T<sub>2</sub>-weighted ratio image analyses were carried out. A combination of automatic segmentation and atlas-based ROI were used in this study. The cohorts were combined using the ComBat batch correction procedure. Results: Group differences were found in the putamen (p = 0.040), with higher T<sub>1</sub>/T<sub>2</sub>-weighted ratio in this region in PSP compared to PD and healthy controls (p-values 0.010 and 0.007 respectively). Using putaminal T<sub>1</sub>/T<sub>2</sub>-weighted ratio for diagnostic separation, a fair performance was found in separating PSP from healthy controls, with an area under the receiver operating characteristic curve of 0.701. Conclusion: Different patterns of T<sub>1</sub>/T<sub>2</sub>-weighted ratio, reflecting differences in underlying pathophysiology, were found between the groups. Since T<sub>1</sub>/T<sub>2</sub>-weighted ratio can be applied to standard clinical MRI sequences to allow more quantitative analyses, this seems to be a promising biomarker for diagnostics and treatment evaluation of parkinsonian disorders for clinical trials.</p>}}, author = {{Sjöström, Henrik and van Westen, Danielle and Hall, Sara and Tjerkaski, Jonathan and Westman, Eric and Muehlboeck, Sebastian and Hansson, Oskar and Svenningsson, Per and Granberg, Tobias}}, issn = {{1353-8020}}, language = {{eng}}, publisher = {{Elsevier}}, series = {{Parkinsonism and Related Disorders}}, title = {{Putaminal T1/T2-weighted ratio is increased in PSP compared to PD and healthy controls, a multi-cohort study}}, url = {{http://dx.doi.org/10.1016/j.parkreldis.2024.106047}}, doi = {{10.1016/j.parkreldis.2024.106047}}, volume = {{121}}, year = {{2024}}, }