Transport properties of aqueous solutions of the oncologic drug 5-fluorouracil : A fundamental complement to therapeutics
(2021) In Journal of Chemical Thermodynamics 161.- Abstract
Cancer pharmacology is often markedly toxic and must be precisely dosed in order to reach the therapeutic bioavailability under strict control. Transport properties are important tools in the process of interpretation and fine-tuning pharmaceutical applications, notably for drugs that have a long record of use and have met their limits of bioavailability. 5–Fluorouracil (5-FU) is one of the most used antineoplastic agents since its discovery in 1957. In this paper, binary mutual diffusion coefficients of 5-fluorouracil, obtained from a Taylor dispersion method setup are reported for aqueous solutions up to 75 mmol.kg−1. These data were complemented by viscosity measurements. The overall information allows to compute... (More)
Cancer pharmacology is often markedly toxic and must be precisely dosed in order to reach the therapeutic bioavailability under strict control. Transport properties are important tools in the process of interpretation and fine-tuning pharmaceutical applications, notably for drugs that have a long record of use and have met their limits of bioavailability. 5–Fluorouracil (5-FU) is one of the most used antineoplastic agents since its discovery in 1957. In this paper, binary mutual diffusion coefficients of 5-fluorouracil, obtained from a Taylor dispersion method setup are reported for aqueous solutions up to 75 mmol.kg−1. These data were complemented by viscosity measurements. The overall information allows to compute descriptive parameters and further interpretation on the basis of well-established models.
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- author
- Verissimo, Luis M.P. ; Cabral, Inês ; Cabral, Ana M.T.D.P.V. ; Utzeri, Gianluca LU ; Veiga, Francisco J.B. ; Valente, Artur J.M. and Ribeiro, Ana C.F.
- publishing date
- 2021-10
- type
- Contribution to journal
- publication status
- published
- keywords
- 5-Fluorouracil, Aqueous solutions, Binary mutual diffusion, Oncologic drugs transport properties
- in
- Journal of Chemical Thermodynamics
- volume
- 161
- article number
- 106533
- publisher
- Academic Press
- external identifiers
-
- scopus:85106583028
- ISSN
- 0021-9614
- DOI
- 10.1016/j.jct.2021.106533
- language
- English
- LU publication?
- no
- additional info
- Publisher Copyright: © 2021 Elsevier Ltd
- id
- 6e8145b8-8388-47c6-9cac-e47ce1cdf308
- date added to LUP
- 2024-07-22 10:54:22
- date last changed
- 2024-08-15 10:11:49
@article{6e8145b8-8388-47c6-9cac-e47ce1cdf308, abstract = {{<p>Cancer pharmacology is often markedly toxic and must be precisely dosed in order to reach the therapeutic bioavailability under strict control. Transport properties are important tools in the process of interpretation and fine-tuning pharmaceutical applications, notably for drugs that have a long record of use and have met their limits of bioavailability. 5–Fluorouracil (5-FU) is one of the most used antineoplastic agents since its discovery in 1957. In this paper, binary mutual diffusion coefficients of 5-fluorouracil, obtained from a Taylor dispersion method setup are reported for aqueous solutions up to 75 mmol.kg<sup>−1</sup>. These data were complemented by viscosity measurements. The overall information allows to compute descriptive parameters and further interpretation on the basis of well-established models.</p>}}, author = {{Verissimo, Luis M.P. and Cabral, Inês and Cabral, Ana M.T.D.P.V. and Utzeri, Gianluca and Veiga, Francisco J.B. and Valente, Artur J.M. and Ribeiro, Ana C.F.}}, issn = {{0021-9614}}, keywords = {{5-Fluorouracil; Aqueous solutions; Binary mutual diffusion; Oncologic drugs transport properties}}, language = {{eng}}, publisher = {{Academic Press}}, series = {{Journal of Chemical Thermodynamics}}, title = {{Transport properties of aqueous solutions of the oncologic drug 5-fluorouracil : A fundamental complement to therapeutics}}, url = {{http://dx.doi.org/10.1016/j.jct.2021.106533}}, doi = {{10.1016/j.jct.2021.106533}}, volume = {{161}}, year = {{2021}}, }