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Effects of acute hydration changes on cardiovascular magnetic resonance native T1 and T2 mapping

Myhr, Katrine Aagaard ; Keceli, Emel ; Kunkel, Joakim Bo ; Kristensen, Charlotte Burup LU orcid ; Vejlstrup, Niels ; Køber, Lars and Pecini, Redi (2024) In International Journal of Cardiovascular Imaging 41(2). p.199-209
Abstract

Changes in hydration status may affect myocardial native T1 and T2 values and influence the clinical interpretation. We aimed to assess the impact of acute preload augmentation on native T1 and T2. Cardiovascular magnetic resonance (CMR) native T1 and T2 mapping were performed twice on the same day in 20 healthy participants before and after an acute preload augmentation by a 2-liter intravenous infusion of isotonic sodium chloride (0.9%). Test-retest reproducibility was evaluated in 30 healthy participants with two consecutive CMR examinations on the same day. Sixteen participants were included in both substudies. In the 20 healthy participants undergoing acute preload augmentation (55% males, mean age (interquartile range [IQR]) 43... (More)

Changes in hydration status may affect myocardial native T1 and T2 values and influence the clinical interpretation. We aimed to assess the impact of acute preload augmentation on native T1 and T2. Cardiovascular magnetic resonance (CMR) native T1 and T2 mapping were performed twice on the same day in 20 healthy participants before and after an acute preload augmentation by a 2-liter intravenous infusion of isotonic sodium chloride (0.9%). Test-retest reproducibility was evaluated in 30 healthy participants with two consecutive CMR examinations on the same day. Sixteen participants were included in both substudies. In the 20 healthy participants undergoing acute preload augmentation (55% males, mean age (interquartile range [IQR]) 43 [29–51] years), native T1 increased with 17 ms (95% confidence interval [CI] 7 to 26; p = 0.001), T2 with 1.7 ms (95% CI 0.8 to 2.4; p < 0.001), and blood T1 with 46 ms (95% CI 28 to 65; p < 0.001). Test-retest variability in 30 healthy participants (47% males, median age 43 [28–52] years) showed 95% limits of agreement (LOA) of ± 26 ms for native T1, ± 2.1 ms for T2, and ± 57 ms for blood T1. In the 16 participants included in both substudies, the mean differences in changes post-infusion versus test-retest were 22 ms (95% CI 8 to 36; p = 0.01) for native T1, 1.9 ms (95% CI 0.9 to 2.9; p = 0.001) for T2, and 62 ms (95% CI 32 to 91; p < 0.001) for blood T1. Native T1 and T2 values increased following acute preload augmentation. However, the changes were within the 95% LOA of the test-retest reproducibility.

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author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Cardiovascular magnetic resonance, Hydration status, Native T1 mapping, T2 mapping
in
International Journal of Cardiovascular Imaging
volume
41
issue
2
pages
11 pages
publisher
Springer
external identifiers
  • scopus:85213015872
  • pmid:39724439
ISSN
1569-5794
DOI
10.1007/s10554-024-03291-9
language
English
LU publication?
yes
id
704f797a-a569-4a74-947a-6eddf0c34b2e
date added to LUP
2025-01-30 10:03:21
date last changed
2025-07-17 23:50:14
@article{704f797a-a569-4a74-947a-6eddf0c34b2e,
  abstract     = {{<p>Changes in hydration status may affect myocardial native T1 and T2 values and influence the clinical interpretation. We aimed to assess the impact of acute preload augmentation on native T1 and T2. Cardiovascular magnetic resonance (CMR) native T1 and T2 mapping were performed twice on the same day in 20 healthy participants before and after an acute preload augmentation by a 2-liter intravenous infusion of isotonic sodium chloride (0.9%). Test-retest reproducibility was evaluated in 30 healthy participants with two consecutive CMR examinations on the same day. Sixteen participants were included in both substudies. In the 20 healthy participants undergoing acute preload augmentation (55% males, mean age (interquartile range [IQR]) 43 [29–51] years), native T1 increased with 17 ms (95% confidence interval [CI] 7 to 26; p = 0.001), T2 with 1.7 ms (95% CI 0.8 to 2.4; p &lt; 0.001), and blood T1 with 46 ms (95% CI 28 to 65; p &lt; 0.001). Test-retest variability in 30 healthy participants (47% males, median age 43 [28–52] years) showed 95% limits of agreement (LOA) of ± 26 ms for native T1, ± 2.1 ms for T2, and ± 57 ms for blood T1. In the 16 participants included in both substudies, the mean differences in changes post-infusion versus test-retest were 22 ms (95% CI 8 to 36; p = 0.01) for native T1, 1.9 ms (95% CI 0.9 to 2.9; p = 0.001) for T2, and 62 ms (95% CI 32 to 91; p &lt; 0.001) for blood T1. Native T1 and T2 values increased following acute preload augmentation. However, the changes were within the 95% LOA of the test-retest reproducibility.</p>}},
  author       = {{Myhr, Katrine Aagaard and Keceli, Emel and Kunkel, Joakim Bo and Kristensen, Charlotte Burup and Vejlstrup, Niels and Køber, Lars and Pecini, Redi}},
  issn         = {{1569-5794}},
  keywords     = {{Cardiovascular magnetic resonance; Hydration status; Native T1 mapping; T2 mapping}},
  language     = {{eng}},
  number       = {{2}},
  pages        = {{199--209}},
  publisher    = {{Springer}},
  series       = {{International Journal of Cardiovascular Imaging}},
  title        = {{Effects of acute hydration changes on cardiovascular magnetic resonance native T1 and T2 mapping}},
  url          = {{http://dx.doi.org/10.1007/s10554-024-03291-9}},
  doi          = {{10.1007/s10554-024-03291-9}},
  volume       = {{41}},
  year         = {{2024}},
}