Predictors of short-term anxiety outcome in subthalamic stimulation for Parkinson’s disease
Sauerbier, A. ; Odin, P. LU
and Dafsari, Haidar Salimi
(2024)
In npj Parkinson's Disease
10(1).
- Abstract
- The effects of subthalamic nucleus deep brain stimulation (STN-DBS) on anxiety in Parkinson’s disease (PD) are understudied. We identified clinical predictors of STN-DBS effects on anxiety in this study. In this prospective, open-label, multicentre study, we assessed patients with anxiety undergoing STN-DBS for PD preoperatively and at 6-month follow-up postoperatively. We assessed the Hospital Anxiety and Depression Scale (HADS-anxiety and depression subscales), Unified PD Rating Scale-motor examination, Scales for Outcomes in PD-motor (SCOPA-M)-activities of daily living (ADL) and -motor complications, Non-Motor Symptom Scale (NMSS), PDQuestionnaire-8 (PDQ-8), and levodopa-equivalent daily dose. We tested changes at follow-up with... (More)
- The effects of subthalamic nucleus deep brain stimulation (STN-DBS) on anxiety in Parkinson’s disease (PD) are understudied. We identified clinical predictors of STN-DBS effects on anxiety in this study. In this prospective, open-label, multicentre study, we assessed patients with anxiety undergoing STN-DBS for PD preoperatively and at 6-month follow-up postoperatively. We assessed the Hospital Anxiety and Depression Scale (HADS-anxiety and depression subscales), Unified PD Rating Scale-motor examination, Scales for Outcomes in PD-motor (SCOPA-M)-activities of daily living (ADL) and -motor complications, Non-Motor Symptom Scale (NMSS), PDQuestionnaire-8 (PDQ-8), and levodopa-equivalent daily dose. We tested changes at follow-up with Wilcoxon signed-rank test and corrected for multiple comparisons (Bonferroni method). We identified patients with a clinically relevant anxiety improvement of anxiety based on a designated threshold of ½ standard deviation of baseline HADS-anxiety. Moreover, we investigated predictors of HADS-anxiety changes with correlations and linear regressions. We included 50 patients with clinically relevant baseline anxiety (i.e., HADS-anxiety ≥ 8) aged 63.1 years ± 8.3 with 10.4 years ± 4.5 PD duration. HADS-anxiety improved significantly at 6-month follow-up as 80% of our cohort experienced clinically relevant anxiety improvement. In predictor analyses, worse baseline SCOPA-ADL and NMSS-urinary domain were associated with greater HADS-anxiety improvements. HADS-anxiety and PDQ-8 changes correlated moderately. Worse preoperative ADL and urinary symptoms predicted favourable postoperative anxiety outcome, which in turn was directly proportionate to greater QoL improvement. This study highlights the importance of detailed anxiety assessments alongside other non-motor and motor symptoms when advising and monitoring patients undergoing STN-DBS for PD. © The Author(s) 2024. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/7290a5b6-f390-4b2f-a5f9-3af642517ff8
- author
- Sauerbier, A.
; Odin, P.
LU
and Dafsari, Haidar Salimi
- author collaboration
- organization
- publishing date
- 2024
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- levodopa, adult, aged, anxiety, Article, brain depth stimulation, clinical article, clinical trial, controlled study, daily life activity, disease duration, female, follow up, Hospital Anxiety and Depression Scale, human, ICD-10, male, multicenter study, Non-Motor Symptoms Scale, Parkinson disease, prediction, prospective study, quality of life, questionnaire, subthalamic nucleus, Unified Parkinson Disease Rating Scale
- in
- npj Parkinson's Disease
- volume
- 10
- issue
- 1
- article number
- 114
- publisher
- Springer Nature
- external identifiers
-
- scopus:85195692254
- pmid:38851717
- ISSN
- 2373-8057
- DOI
- 10.1038/s41531-024-00701-6
- language
- English
- LU publication?
- yes
- id
- 7290a5b6-f390-4b2f-a5f9-3af642517ff8
- date added to LUP
- 2024-08-29 14:05:35
- date last changed
- 2024-08-30 03:07:30
@article{7290a5b6-f390-4b2f-a5f9-3af642517ff8,
abstract = {{The effects of subthalamic nucleus deep brain stimulation (STN-DBS) on anxiety in Parkinson’s disease (PD) are understudied. We identified clinical predictors of STN-DBS effects on anxiety in this study. In this prospective, open-label, multicentre study, we assessed patients with anxiety undergoing STN-DBS for PD preoperatively and at 6-month follow-up postoperatively. We assessed the Hospital Anxiety and Depression Scale (HADS-anxiety and depression subscales), Unified PD Rating Scale-motor examination, Scales for Outcomes in PD-motor (SCOPA-M)-activities of daily living (ADL) and -motor complications, Non-Motor Symptom Scale (NMSS), PDQuestionnaire-8 (PDQ-8), and levodopa-equivalent daily dose. We tested changes at follow-up with Wilcoxon signed-rank test and corrected for multiple comparisons (Bonferroni method). We identified patients with a clinically relevant anxiety improvement of anxiety based on a designated threshold of ½ standard deviation of baseline HADS-anxiety. Moreover, we investigated predictors of HADS-anxiety changes with correlations and linear regressions. We included 50 patients with clinically relevant baseline anxiety (i.e., HADS-anxiety ≥ 8) aged 63.1 years ± 8.3 with 10.4 years ± 4.5 PD duration. HADS-anxiety improved significantly at 6-month follow-up as 80% of our cohort experienced clinically relevant anxiety improvement. In predictor analyses, worse baseline SCOPA-ADL and NMSS-urinary domain were associated with greater HADS-anxiety improvements. HADS-anxiety and PDQ-8 changes correlated moderately. Worse preoperative ADL and urinary symptoms predicted favourable postoperative anxiety outcome, which in turn was directly proportionate to greater QoL improvement. This study highlights the importance of detailed anxiety assessments alongside other non-motor and motor symptoms when advising and monitoring patients undergoing STN-DBS for PD. © The Author(s) 2024.}},
author = {{Sauerbier, A. and Odin, P. and Dafsari, Haidar Salimi}},
issn = {{2373-8057}},
keywords = {{levodopa; adult; aged; anxiety; Article; brain depth stimulation; clinical article; clinical trial; controlled study; daily life activity; disease duration; female; follow up; Hospital Anxiety and Depression Scale; human; ICD-10; male; multicenter study; Non-Motor Symptoms Scale; Parkinson disease; prediction; prospective study; quality of life; questionnaire; subthalamic nucleus; Unified Parkinson Disease Rating Scale}},
language = {{eng}},
number = {{1}},
publisher = {{Springer Nature}},
series = {{npj Parkinson's Disease}},
title = {{Predictors of short-term anxiety outcome in subthalamic stimulation for Parkinson’s disease}},
url = {{http://dx.doi.org/10.1038/s41531-024-00701-6}},
doi = {{10.1038/s41531-024-00701-6}},
volume = {{10}},
year = {{2024}},
}