Body Mass Index Is Associated with Impaired Semen Characteristics and Reduced Levels of Anti-Müllerian Hormone across a Wide Weight Range.
(2015) In PLoS ONE 10(6).- Abstract
- There is still controversy as to how body mass index (BMI) affects male reproduction. We investigated how BMI is associated with semen quality and reproductive hormones in 166 men, including 38 severely obese men. Standard semen analysis and sperm DNA integrity analysis were performed, and blood samples were analysed for reproductive hormones. Adjusted for age and time of abstinence, BMI was negatively associated with sperm concentration (B = -0.088, P = 0.009), total sperm count (B = -0.223, P = 0.001), progressive sperm motility (B = -0.675, P = 0.007), normal sperm morphology (B = -0.078, P = 0.001), and percentage of vital spermatozoa (B = -0.006, P = 0.027). A negative relationship was observed between BMI and total testosterone (B =... (More)
- There is still controversy as to how body mass index (BMI) affects male reproduction. We investigated how BMI is associated with semen quality and reproductive hormones in 166 men, including 38 severely obese men. Standard semen analysis and sperm DNA integrity analysis were performed, and blood samples were analysed for reproductive hormones. Adjusted for age and time of abstinence, BMI was negatively associated with sperm concentration (B = -0.088, P = 0.009), total sperm count (B = -0.223, P = 0.001), progressive sperm motility (B = -0.675, P = 0.007), normal sperm morphology (B = -0.078, P = 0.001), and percentage of vital spermatozoa (B = -0.006, P = 0.027). A negative relationship was observed between BMI and total testosterone (B = -0.378, P < 0.001), sex hormone binding globulin (B = -0.572, P < 0.001), inhibin B (B = -3.120, P < 0.001) and anti-Müllerian hormone (AMH) (B = -0.009, P < 0.001). Our findings suggest that high BMI is negatively associated with semen characteristics and serum levels of AMH. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/7486779
- author
- Andersen, Jorunn M ; Herning, Hilde ; Aschim, Elin L ; Hjelmesæth, Jøran ; Mala, Tom ; Hanevik, Hans Ivar ; Bungum, Mona LU ; Haugen, Trine B and Witczak, Oliwia
- organization
- publishing date
- 2015
- type
- Contribution to journal
- publication status
- published
- subject
- in
- PLoS ONE
- volume
- 10
- issue
- 6
- article number
- e0130210
- publisher
- Public Library of Science (PLoS)
- external identifiers
-
- pmid:26067627
- wos:000356327000151
- scopus:84936163972
- pmid:26067627
- ISSN
- 1932-6203
- DOI
- 10.1371/journal.pone.0130210
- language
- English
- LU publication?
- yes
- id
- 6bf3ab7c-4268-4fe7-8b46-b17db70136eb (old id 7486779)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/26067627?dopt=Abstract
- date added to LUP
- 2016-04-01 14:39:54
- date last changed
- 2022-05-07 23:59:53
@article{6bf3ab7c-4268-4fe7-8b46-b17db70136eb, abstract = {{There is still controversy as to how body mass index (BMI) affects male reproduction. We investigated how BMI is associated with semen quality and reproductive hormones in 166 men, including 38 severely obese men. Standard semen analysis and sperm DNA integrity analysis were performed, and blood samples were analysed for reproductive hormones. Adjusted for age and time of abstinence, BMI was negatively associated with sperm concentration (B = -0.088, P = 0.009), total sperm count (B = -0.223, P = 0.001), progressive sperm motility (B = -0.675, P = 0.007), normal sperm morphology (B = -0.078, P = 0.001), and percentage of vital spermatozoa (B = -0.006, P = 0.027). A negative relationship was observed between BMI and total testosterone (B = -0.378, P < 0.001), sex hormone binding globulin (B = -0.572, P < 0.001), inhibin B (B = -3.120, P < 0.001) and anti-Müllerian hormone (AMH) (B = -0.009, P < 0.001). Our findings suggest that high BMI is negatively associated with semen characteristics and serum levels of AMH.}}, author = {{Andersen, Jorunn M and Herning, Hilde and Aschim, Elin L and Hjelmesæth, Jøran and Mala, Tom and Hanevik, Hans Ivar and Bungum, Mona and Haugen, Trine B and Witczak, Oliwia}}, issn = {{1932-6203}}, language = {{eng}}, number = {{6}}, publisher = {{Public Library of Science (PLoS)}}, series = {{PLoS ONE}}, title = {{Body Mass Index Is Associated with Impaired Semen Characteristics and Reduced Levels of Anti-Müllerian Hormone across a Wide Weight Range.}}, url = {{https://lup.lub.lu.se/search/files/4094316/8627247}}, doi = {{10.1371/journal.pone.0130210}}, volume = {{10}}, year = {{2015}}, }