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Pharmacological modulation of vascular ageing: a review from VascAgeNet

Roth, Lynn ; Dogan, Soner ; Tuna, Bilge guvenc ; Aranyi, Tamas ; Benitez, Sonia ; Borrell-Pages, Maria ; Bozaykut, Perinur ; De meyer, Guido r.y. ; Duca, Laurent and Durmus, Nergiz , et al. (2023) In Ageing Research Reviews
Abstract
Vascular ageing, characterized by structural and functional changes in blood vessels of which arterial stiffness and endothelial dysfunction are key components, is associated with increased risk of cardiovascular and other age-related diseases. As the global population continues to age, understanding the underlying mechanisms and developing effective therapeutic interventions to mitigate vascular ageing becomes crucial for improving cardiovascular health outcomes. Therefore, this review provides an overview of the current knowledge on pharmacological modulation of vascular ageing, highlighting key strategies and promising therapeutic targets. Several molecular pathways have been identified as central players in vascular ageing, including... (More)
Vascular ageing, characterized by structural and functional changes in blood vessels of which arterial stiffness and endothelial dysfunction are key components, is associated with increased risk of cardiovascular and other age-related diseases. As the global population continues to age, understanding the underlying mechanisms and developing effective therapeutic interventions to mitigate vascular ageing becomes crucial for improving cardiovascular health outcomes. Therefore, this review provides an overview of the current knowledge on pharmacological modulation of vascular ageing, highlighting key strategies and promising therapeutic targets. Several molecular pathways have been identified as central players in vascular ageing, including oxidative stress and inflammation, the renin-angiotensin-aldosterone system, cellular senescence, macroautophagy, extracellular matrix remodelling, calcification, and gasotransmitter-related signalling. Pharmacological and dietary interventions targeting these pathways have shown potential in ameliorating age-related vascular changes. Nevertheless, the development and application of drugs targeting vascular ageing is complicated by various inherent challenges and limitations, such as certain preclinical methodological considerations, interactions with exercise training and sex/gender-related differences, which should be taken into account. Overall, pharmacological modulation of endothelial dysfunction and arterial stiffness as hallmarks of vascular ageing, holds great promise for improving cardiovascular health in the ageing population. Nonetheless, further research is needed to fully elucidate the underlying mechanisms and optimize the efficacy and safety of these interventions for clinical translation. (Less)
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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
vascular ageing
in
Ageing Research Reviews
article number
102122
publisher
Elsevier
external identifiers
  • scopus:85177763196
  • pmid:37956927
ISSN
1872-9649
DOI
10.1016/j.arr.2023.102122
project
Vascular Ageing and Arterial Stiffness in the Swedish Population
language
English
LU publication?
yes
id
749d8b64-88d4-47a9-aad9-dc227e267354
date added to LUP
2023-11-13 14:00:56
date last changed
2024-06-15 15:36:48
@article{749d8b64-88d4-47a9-aad9-dc227e267354,
  abstract     = {{Vascular ageing, characterized by structural and functional changes in blood vessels of which arterial stiffness and endothelial dysfunction are key components, is associated with increased risk of cardiovascular and other age-related diseases. As the global population continues to age, understanding the underlying mechanisms and developing effective therapeutic interventions to mitigate vascular ageing becomes crucial for improving cardiovascular health outcomes. Therefore, this review provides an overview of the current knowledge on pharmacological modulation of vascular ageing, highlighting key strategies and promising therapeutic targets. Several molecular pathways have been identified as central players in vascular ageing, including oxidative stress and inflammation, the renin-angiotensin-aldosterone system, cellular senescence, macroautophagy, extracellular matrix remodelling, calcification, and gasotransmitter-related signalling. Pharmacological and dietary interventions targeting these pathways have shown potential in ameliorating age-related vascular changes. Nevertheless, the development and application of drugs targeting vascular ageing is complicated by various inherent challenges and limitations, such as certain preclinical methodological considerations, interactions with exercise training and sex/gender-related differences, which should be taken into account. Overall, pharmacological modulation of endothelial dysfunction and arterial stiffness as hallmarks of vascular ageing, holds great promise for improving cardiovascular health in the ageing population. Nonetheless, further research is needed to fully elucidate the underlying mechanisms and optimize the efficacy and safety of these interventions for clinical translation.}},
  author       = {{Roth, Lynn and Dogan, Soner and Tuna, Bilge guvenc and Aranyi, Tamas and Benitez, Sonia and Borrell-Pages, Maria and Bozaykut, Perinur and De meyer, Guido r.y. and Duca, Laurent and Durmus, Nergiz and Fonseca, Diogo and Fraenkel, Emil and Gillery, Philippe and Giudici, Alessandro and Jaisson, Stéphane and Johansson, Madeleine and Julve, Josep and Lucas-Herald, Angela k. and Martinet, Wim and Maurice, Pascal and Mcdonnell, Barry and Ozbek, Emine nur and Pucci, Giacomo and Pugh, Christopher j.a. and Rochfort, Keith d. and Roks, Anton j.m. and Rotllan, Noemi and Shadiow, James and Sohrabi, Yahya and Spronck, Bart and Szeri, Flora and Terentes-Printzios, Dimitrios and Aydın, Elif tunç and Tura-Ceide, Olga and Ucar, Eda and Anacak, Gunay yetik}},
  issn         = {{1872-9649}},
  keywords     = {{vascular ageing}},
  language     = {{eng}},
  month        = {{11}},
  publisher    = {{Elsevier}},
  series       = {{Ageing Research Reviews}},
  title        = {{Pharmacological modulation of vascular ageing: a review from VascAgeNet}},
  url          = {{http://dx.doi.org/10.1016/j.arr.2023.102122}},
  doi          = {{10.1016/j.arr.2023.102122}},
  year         = {{2023}},
}