SAMHD1 Limits the Efficacy of Forodesine in Leukemia by Protecting Cells against the Cytotoxicity of dGTP
(2020) In Cell Reports 31(6).- Abstract
SAMHD1 degrades deoxyribonucleoside triphosphates (dNTPs), the building blocks of DNA. Davenne et al. find that SAMHD1 protects cells against dNTP imbalances. Exposure of SAMHD1-deficient cells to deoxyguanosine (dG) results in increased intracellular dGTP levels and subsequent apoptosis. This can be exploited to selectively kill cancer cells that acquired SAMHD1 mutations.
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https://lup.lub.lu.se/record/74bec4fe-e0ac-473e-9237-055d9cb8f468
- author
- publishing date
- 2020-05-12
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- apoptosis, BCX-1777, chronic lymphocytic leukemia, CyTOF, deoxyguanosine, dGTP, dNTP, forodesine, Immucillin H, SAMHD1
- in
- Cell Reports
- volume
- 31
- issue
- 6
- article number
- 107640
- publisher
- Cell Press
- external identifiers
-
- scopus:85084344520
- pmid:32402273
- ISSN
- 2211-1247
- DOI
- 10.1016/j.celrep.2020.107640
- language
- English
- LU publication?
- no
- id
- 74bec4fe-e0ac-473e-9237-055d9cb8f468
- date added to LUP
- 2020-11-26 14:25:09
- date last changed
- 2024-06-27 02:21:57
@article{74bec4fe-e0ac-473e-9237-055d9cb8f468, abstract = {{<p>SAMHD1 degrades deoxyribonucleoside triphosphates (dNTPs), the building blocks of DNA. Davenne et al. find that SAMHD1 protects cells against dNTP imbalances. Exposure of SAMHD1-deficient cells to deoxyguanosine (dG) results in increased intracellular dGTP levels and subsequent apoptosis. This can be exploited to selectively kill cancer cells that acquired SAMHD1 mutations.</p>}}, author = {{Davenne, Tamara and Klintman, Jenny and Sharma, Sushma and Rigby, Rachel E. and Blest, Henry T.W. and Cursi, Chiara and Bridgeman, Anne and Dadonaite, Bernadeta and De Keersmaecker, Kim and Hillmen, Peter and Chabes, Andrei and Schuh, Anna and Rehwinkel, Jan}}, issn = {{2211-1247}}, keywords = {{apoptosis; BCX-1777; chronic lymphocytic leukemia; CyTOF; deoxyguanosine; dGTP; dNTP; forodesine; Immucillin H; SAMHD1}}, language = {{eng}}, month = {{05}}, number = {{6}}, publisher = {{Cell Press}}, series = {{Cell Reports}}, title = {{SAMHD1 Limits the Efficacy of Forodesine in Leukemia by Protecting Cells against the Cytotoxicity of dGTP}}, url = {{http://dx.doi.org/10.1016/j.celrep.2020.107640}}, doi = {{10.1016/j.celrep.2020.107640}}, volume = {{31}}, year = {{2020}}, }