Reviewing the role of the genes G72 and DAAO in glutamate neurotransmission in schizophrenia
(2007) In European Neuropsychopharmacology 17(9). p.567-572- Abstract
We review the role of two susceptibility genes; G72 and DAAO in glutamate neurotransmission and the aetiology of schizophrenia. The gene product of G72 is an activator of DAAO (D-amino acid oxidase), which is the only enzyme oxidising D-serine. D-serine is an important co-agonist for the NMDA glutamate receptor and plays a role in neuronal migration and cell death. Studies of D-serine revealed lower serum levels in schizophrenia patients as compared to healthy controls. Furthermore, administration of D-serine as add-on medication reduced the symptoms of schizophrenia. The underlying mechanism of the involvement of G72 and DAAO in schizophrenia is probably based on decreased levels of D-serine and decreased NMDA receptor functioning in... (More)
We review the role of two susceptibility genes; G72 and DAAO in glutamate neurotransmission and the aetiology of schizophrenia. The gene product of G72 is an activator of DAAO (D-amino acid oxidase), which is the only enzyme oxidising D-serine. D-serine is an important co-agonist for the NMDA glutamate receptor and plays a role in neuronal migration and cell death. Studies of D-serine revealed lower serum levels in schizophrenia patients as compared to healthy controls. Furthermore, administration of D-serine as add-on medication reduced the symptoms of schizophrenia. The underlying mechanism of the involvement of G72 and DAAO in schizophrenia is probably based on decreased levels of D-serine and decreased NMDA receptor functioning in patients. The involvement of this gene is therefore indirect support for the glutamate dysfunction hypothesis in schizophrenia.
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- author
- Boks, M. P.M. ; Rietkerk, T. ; van de Beek, M. H. ; Sommer, I. E. ; de Koning, T. J. LU and Kahn, R. S.
- publishing date
- 2007-09-01
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- D-Serine, DAAO;, G72;, Glutamate;, Schizophrenia;
- in
- European Neuropsychopharmacology
- volume
- 17
- issue
- 9
- pages
- 6 pages
- publisher
- Elsevier
- external identifiers
-
- scopus:34447550448
- pmid:17250995
- ISSN
- 0924-977X
- DOI
- 10.1016/j.euroneuro.2006.12.003
- language
- English
- LU publication?
- no
- id
- 760bf859-a0ac-4180-a3a1-c0780648f0ec
- date added to LUP
- 2020-02-28 13:57:22
- date last changed
- 2024-05-29 10:17:38
@article{760bf859-a0ac-4180-a3a1-c0780648f0ec,
abstract = {{<p>We review the role of two susceptibility genes; G72 and DAAO in glutamate neurotransmission and the aetiology of schizophrenia. The gene product of G72 is an activator of DAAO (D-amino acid oxidase), which is the only enzyme oxidising D-serine. D-serine is an important co-agonist for the NMDA glutamate receptor and plays a role in neuronal migration and cell death. Studies of D-serine revealed lower serum levels in schizophrenia patients as compared to healthy controls. Furthermore, administration of D-serine as add-on medication reduced the symptoms of schizophrenia. The underlying mechanism of the involvement of G72 and DAAO in schizophrenia is probably based on decreased levels of D-serine and decreased NMDA receptor functioning in patients. The involvement of this gene is therefore indirect support for the glutamate dysfunction hypothesis in schizophrenia.</p>}},
author = {{Boks, M. P.M. and Rietkerk, T. and van de Beek, M. H. and Sommer, I. E. and de Koning, T. J. and Kahn, R. S.}},
issn = {{0924-977X}},
keywords = {{D-Serine; DAAO;; G72;; Glutamate;; Schizophrenia;}},
language = {{eng}},
month = {{09}},
number = {{9}},
pages = {{567--572}},
publisher = {{Elsevier}},
series = {{European Neuropsychopharmacology}},
title = {{Reviewing the role of the genes G72 and DAAO in glutamate neurotransmission in schizophrenia}},
url = {{http://dx.doi.org/10.1016/j.euroneuro.2006.12.003}},
doi = {{10.1016/j.euroneuro.2006.12.003}},
volume = {{17}},
year = {{2007}},
}