Platelets and the immune continuum
(2011) In Nature Reviews Immunology 11(4). p.74-264- Abstract
Platelets are anucleate cells that are crucial mediators of haemostasis. Most immunologists probably don't think about platelets every day, and may even consider these cells to be 'nuisances' in certain in vitro studies. However, it is becoming increasingly clear that platelets have inflammatory functions and can influence both innate and adaptive immune responses. Here, we discuss the mechanisms by which platelets contribute to immunity: these small cells are more immunologically savvy than we once thought.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/76b327e7-614e-4f8a-91e0-5971533aaccf
- author
- Semple, John W LU ; Italiano, Joseph E and Freedman, John
- publishing date
- 2011-04
- type
- Contribution to journal
- publication status
- published
- keywords
- Adaptive Immunity, Animals, Atherosclerosis, Birds, Blood Platelets, Communicable Diseases, Cytokines, Hematopoiesis, Hemostasis, Humans, Immunity, Innate, Inflammation, Mice, Platelet Count, Toll-Like Receptors, Journal Article, Review
- in
- Nature Reviews Immunology
- volume
- 11
- issue
- 4
- pages
- 11 pages
- publisher
- Nature Publishing Group
- external identifiers
-
- pmid:21436837
- scopus:79953150620
- ISSN
- 1474-1741
- DOI
- 10.1038/nri2956
- language
- English
- LU publication?
- no
- id
- 76b327e7-614e-4f8a-91e0-5971533aaccf
- date added to LUP
- 2016-09-23 12:04:54
- date last changed
- 2024-10-06 01:59:40
@article{76b327e7-614e-4f8a-91e0-5971533aaccf, abstract = {{<p>Platelets are anucleate cells that are crucial mediators of haemostasis. Most immunologists probably don't think about platelets every day, and may even consider these cells to be 'nuisances' in certain in vitro studies. However, it is becoming increasingly clear that platelets have inflammatory functions and can influence both innate and adaptive immune responses. Here, we discuss the mechanisms by which platelets contribute to immunity: these small cells are more immunologically savvy than we once thought.</p>}}, author = {{Semple, John W and Italiano, Joseph E and Freedman, John}}, issn = {{1474-1741}}, keywords = {{Adaptive Immunity; Animals; Atherosclerosis; Birds; Blood Platelets; Communicable Diseases; Cytokines; Hematopoiesis; Hemostasis; Humans; Immunity, Innate; Inflammation; Mice; Platelet Count; Toll-Like Receptors; Journal Article; Review}}, language = {{eng}}, number = {{4}}, pages = {{74--264}}, publisher = {{Nature Publishing Group}}, series = {{Nature Reviews Immunology}}, title = {{Platelets and the immune continuum}}, url = {{http://dx.doi.org/10.1038/nri2956}}, doi = {{10.1038/nri2956}}, volume = {{11}}, year = {{2011}}, }