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Irradiation in a flash : Unique sparing of memory in mice after whole brain irradiation with dose rates above 100 Gy/s

Montay-Gruel, Pierre ; Petersson, Kristoffer LU ; Jaccard, Maud ; Boivin, Gaël ; Germond, Jean François ; Petit, Benoit ; Doenlen, Raphaël ; Favaudon, Vincent ; Bochud, François and Bailat, Claude , et al. (2017) In Radiotherapy and Oncology 124(3). p.365-369
Abstract

This study shows for the first time that normal brain tissue toxicities after WBI can be reduced with increased dose rate. Spatial memory is preserved after WBI with mean dose rates above 100 Gy/s, whereas 10 Gy WBI at a conventional radiotherapy dose rate (0.1 Gy/s) totally impairs spatial memory.

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author
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publishing date
type
Contribution to journal
publication status
published
keywords
Cognition's preservation, Flash-RT, Whole brain irradiation
in
Radiotherapy and Oncology
volume
124
issue
3
pages
365 - 369
publisher
Elsevier
external identifiers
  • pmid:28545957
  • scopus:85019639866
ISSN
0167-8140
DOI
10.1016/j.radonc.2017.05.003
language
English
LU publication?
no
additional info
Publisher Copyright: © 2017 Elsevier B.V.
id
778171ab-d7fb-4dff-8868-786abbd029e1
date added to LUP
2021-11-03 18:15:32
date last changed
2024-07-14 23:54:32
@article{778171ab-d7fb-4dff-8868-786abbd029e1,
  abstract     = {{<p>This study shows for the first time that normal brain tissue toxicities after WBI can be reduced with increased dose rate. Spatial memory is preserved after WBI with mean dose rates above 100 Gy/s, whereas 10 Gy WBI at a conventional radiotherapy dose rate (0.1 Gy/s) totally impairs spatial memory.</p>}},
  author       = {{Montay-Gruel, Pierre and Petersson, Kristoffer and Jaccard, Maud and Boivin, Gaël and Germond, Jean François and Petit, Benoit and Doenlen, Raphaël and Favaudon, Vincent and Bochud, François and Bailat, Claude and Bourhis, Jean and Vozenin, Marie Catherine}},
  issn         = {{0167-8140}},
  keywords     = {{Cognition's preservation; Flash-RT; Whole brain irradiation}},
  language     = {{eng}},
  number       = {{3}},
  pages        = {{365--369}},
  publisher    = {{Elsevier}},
  series       = {{Radiotherapy and Oncology}},
  title        = {{Irradiation in a flash : Unique sparing of memory in mice after whole brain irradiation with dose rates above 100 Gy/s}},
  url          = {{http://dx.doi.org/10.1016/j.radonc.2017.05.003}},
  doi          = {{10.1016/j.radonc.2017.05.003}},
  volume       = {{124}},
  year         = {{2017}},
}