Use of common cardiovascular disease drugs and risk of dementia : A case–control study in Swedish national register data
(2025) In Alzheimer's and Dementia 21(1).- Abstract
INTRODUCTION: Cardiovascular drug use may help prevent dementia; however, current evidence is mixed. Using a case–control design, we investigated the association between duration and combination of multiple cardiovascular drug classes and incident dementia. METHODS: From the Swedish national registers, we included 88,065 incident dementia cases aged ≥ 70 at diagnosis between 2011 and 2016 and 880,650 age- and sex-matched controls. Cardiovascular drug use was ascertained from the Prescribed Drug Register. RESULTS: Long-term users (≥ 5 years) of antihypertensives, diuretics, lipid-lowering drugs (LLDs), and oral anticoagulants (OACs) had statistically significantly fewer dementia diagnoses (odds ratio [OR] 0.75–0.91) than non-users.... (More)
INTRODUCTION: Cardiovascular drug use may help prevent dementia; however, current evidence is mixed. Using a case–control design, we investigated the association between duration and combination of multiple cardiovascular drug classes and incident dementia. METHODS: From the Swedish national registers, we included 88,065 incident dementia cases aged ≥ 70 at diagnosis between 2011 and 2016 and 880,650 age- and sex-matched controls. Cardiovascular drug use was ascertained from the Prescribed Drug Register. RESULTS: Long-term users (≥ 5 years) of antihypertensives, diuretics, lipid-lowering drugs (LLDs), and oral anticoagulants (OACs) had statistically significantly fewer dementia diagnoses (odds ratio [OR] 0.75–0.91) than non-users. Antiplatelets use was associated with more dementia diagnoses (OR 1.13–1.25). Use of antihypertensives in combination with diuretics, LLDs, and OACs for ≥ 5 years was associated with fewer dementia diagnoses (OR 0.66–0.84). DISCUSSION: Preventing dementia via cardiovascular drug pathways may be possible. It is however important to consider the potential long-term negative cognitive effect of antiplatelets. Highlights: Use ≥ 5 years of common cardiovascular drugs was associated with lower dementia risk. Common cardiovascular drug combination use was associated with lower dementia risk. Anti-platelet use of any duration was associated with higher dementia risk.
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- author
- Ding, Mozhu LU ; Wennberg, Alexandra M. ; Engström, Gunnar LU and Modig, Karin
- organization
- publishing date
- 2025
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- cardiovascular disease, cardiovascular drugs, case–control study, dementia
- in
- Alzheimer's and Dementia
- volume
- 21
- issue
- 1
- publisher
- Wiley
- external identifiers
-
- pmid:39555901
- scopus:85209793498
- ISSN
- 1552-5260
- DOI
- 10.1002/alz.14389
- language
- English
- LU publication?
- yes
- additional info
- Publisher Copyright: © 2024 The Author(s). Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.
- id
- 7792a7c1-2eba-4451-adeb-4c330976c3ef
- date added to LUP
- 2025-01-23 09:56:15
- date last changed
- 2025-12-12 14:04:00
@article{7792a7c1-2eba-4451-adeb-4c330976c3ef,
abstract = {{<p>INTRODUCTION: Cardiovascular drug use may help prevent dementia; however, current evidence is mixed. Using a case–control design, we investigated the association between duration and combination of multiple cardiovascular drug classes and incident dementia. METHODS: From the Swedish national registers, we included 88,065 incident dementia cases aged ≥ 70 at diagnosis between 2011 and 2016 and 880,650 age- and sex-matched controls. Cardiovascular drug use was ascertained from the Prescribed Drug Register. RESULTS: Long-term users (≥ 5 years) of antihypertensives, diuretics, lipid-lowering drugs (LLDs), and oral anticoagulants (OACs) had statistically significantly fewer dementia diagnoses (odds ratio [OR] 0.75–0.91) than non-users. Antiplatelets use was associated with more dementia diagnoses (OR 1.13–1.25). Use of antihypertensives in combination with diuretics, LLDs, and OACs for ≥ 5 years was associated with fewer dementia diagnoses (OR 0.66–0.84). DISCUSSION: Preventing dementia via cardiovascular drug pathways may be possible. It is however important to consider the potential long-term negative cognitive effect of antiplatelets. Highlights: Use ≥ 5 years of common cardiovascular drugs was associated with lower dementia risk. Common cardiovascular drug combination use was associated with lower dementia risk. Anti-platelet use of any duration was associated with higher dementia risk.</p>}},
author = {{Ding, Mozhu and Wennberg, Alexandra M. and Engström, Gunnar and Modig, Karin}},
issn = {{1552-5260}},
keywords = {{cardiovascular disease; cardiovascular drugs; case–control study; dementia}},
language = {{eng}},
number = {{1}},
publisher = {{Wiley}},
series = {{Alzheimer's and Dementia}},
title = {{Use of common cardiovascular disease drugs and risk of dementia : A case–control study in Swedish national register data}},
url = {{http://dx.doi.org/10.1002/alz.14389}},
doi = {{10.1002/alz.14389}},
volume = {{21}},
year = {{2025}},
}