Potential Biomarkers for Radiation-Induced Renal Toxicity following 177Lu-Octreotate Administration in Mice.
(2015) In PLoS ONE 10(8).- Abstract
- C57BL/6N mice were i.v. injected with 0, 30, 60, 90, 120, or 150 MBq 177Lu-octreotate (0, 16, 29, 40, 48, and 54 Gy to the kidneys). At 4, 8, and 12 months after administration, radiation-induced effects were evaluated in relation to (a) global transcriptional variations in kidney tissues, (b) morphological changes in the kidneys, (c) changes in white and red blood cell count as well as blood levels of urea, and (d) changes in renal function using 99mTc-DTPA/99mTc-DMSA scintigraphy.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/7840600
- author
- Schüler, Emil ; Larsson, Maria ; Parris, Toshima Z ; Johansson, Martin LU ; Helou, Khalil and Forssell-Aronsson, Eva
- organization
- publishing date
- 2015
- type
- Contribution to journal
- publication status
- published
- subject
- in
- PLoS ONE
- volume
- 10
- issue
- 8
- article number
- e0136204
- publisher
- Public Library of Science (PLoS)
- external identifiers
-
- pmid:26287527
- wos:000360018600122
- scopus:84942456163
- pmid:26287527
- ISSN
- 1932-6203
- DOI
- 10.1371/journal.pone.0136204
- language
- English
- LU publication?
- yes
- id
- 79cb06f6-6b1c-4b8c-a181-ee898eadc213 (old id 7840600)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/26287527?dopt=Abstract
- date added to LUP
- 2016-04-01 13:09:57
- date last changed
- 2022-03-29 05:56:28
@article{79cb06f6-6b1c-4b8c-a181-ee898eadc213,
abstract = {{C57BL/6N mice were i.v. injected with 0, 30, 60, 90, 120, or 150 MBq 177Lu-octreotate (0, 16, 29, 40, 48, and 54 Gy to the kidneys). At 4, 8, and 12 months after administration, radiation-induced effects were evaluated in relation to (a) global transcriptional variations in kidney tissues, (b) morphological changes in the kidneys, (c) changes in white and red blood cell count as well as blood levels of urea, and (d) changes in renal function using 99mTc-DTPA/99mTc-DMSA scintigraphy.}},
author = {{Schüler, Emil and Larsson, Maria and Parris, Toshima Z and Johansson, Martin and Helou, Khalil and Forssell-Aronsson, Eva}},
issn = {{1932-6203}},
language = {{eng}},
number = {{8}},
publisher = {{Public Library of Science (PLoS)}},
series = {{PLoS ONE}},
title = {{Potential Biomarkers for Radiation-Induced Renal Toxicity following 177Lu-Octreotate Administration in Mice.}},
url = {{https://lup.lub.lu.se/search/files/3198824/8603328}},
doi = {{10.1371/journal.pone.0136204}},
volume = {{10}},
year = {{2015}},
}