Non protein bound iron concentrations in amniotic fluid
Gazzolo, D ; Perrone, S ; Paffetti, P ; Longini, M ; Vezzosi, P ; Bruschettini, Matteo LU
; Lituania, M
and Buonocore, G
(2005)
In Clinical Biochemistry
38(7).
p.674-677
- Abstract
- Objectives: To investigate whether amniotic fluid concentrations of non protein bound iron (NPBI) vary with growth in healthy fetuses and also offer a reference curve in the second trimester of pregnancy. Design and methods: Amniotic fluid concentrations of NPBI were measured by HPLC in 118 women with physiological singleton pregnancies, who underwent amniocentesis for fetal karyotype between weeks 15 and 18 of gestation. Results: NPBI increased progressively from weeks 14-15 to weeks 15-16, peaking at 17-18 weeks of gestation. NPBI values regressed positively with gestational age (GA). Multiple linear regression analysis between NPBI, as dependent variable, and various fetal parameters, as independent variables, showed a statistically... (More)
- Objectives: To investigate whether amniotic fluid concentrations of non protein bound iron (NPBI) vary with growth in healthy fetuses and also offer a reference curve in the second trimester of pregnancy. Design and methods: Amniotic fluid concentrations of NPBI were measured by HPLC in 118 women with physiological singleton pregnancies, who underwent amniocentesis for fetal karyotype between weeks 15 and 18 of gestation. Results: NPBI increased progressively from weeks 14-15 to weeks 15-16, peaking at 17-18 weeks of gestation. NPBI values regressed positively with gestational age (GA). Multiple linear regression analysis between NPBI, as dependent variable, and various fetal parameters, as independent variables, showed a statistically significant regression coefficient with GA, bi-parietal diameter and transverse cerebellar diameter. Conclusions: The present data constitutes the first quantification of NPBI concentrations in amniotic fluid under physiological conditions. Correlations with GA and ultrasound fetal biometry suggest that NPBI may play a role in fetal growth. (C) 2005 The Canadian Society of Clinical Chemists. All rights reserved. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/7856268
- author
- Gazzolo, D
; Perrone, S
; Paffetti, P
; Longini, M
; Vezzosi, P
; Bruschettini, Matteo
LU
; Lituania, M
and Buonocore, G
- publishing date
- 2005
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- stress, oxidative, pregnancy, ammotic fluid, fetus, non protein bound iron
- in
- Clinical Biochemistry
- volume
- 38
- issue
- 7
- pages
- 674 - 677
- publisher
- Elsevier
- external identifiers
-
- wos:000230697100012
- scopus:21844441618
- ISSN
- 1873-2933
- DOI
- 10.1016/j.clinbiochem.2005.03.010
- language
- English
- LU publication?
- no
- id
- d0d42f52-feb7-4b38-b94a-3cf38f22a5b2 (old id 7856268)
- date added to LUP
- 2016-04-01 12:33:11
- date last changed
- 2022-02-03 23:45:24
@article{d0d42f52-feb7-4b38-b94a-3cf38f22a5b2,
abstract = {{Objectives: To investigate whether amniotic fluid concentrations of non protein bound iron (NPBI) vary with growth in healthy fetuses and also offer a reference curve in the second trimester of pregnancy. Design and methods: Amniotic fluid concentrations of NPBI were measured by HPLC in 118 women with physiological singleton pregnancies, who underwent amniocentesis for fetal karyotype between weeks 15 and 18 of gestation. Results: NPBI increased progressively from weeks 14-15 to weeks 15-16, peaking at 17-18 weeks of gestation. NPBI values regressed positively with gestational age (GA). Multiple linear regression analysis between NPBI, as dependent variable, and various fetal parameters, as independent variables, showed a statistically significant regression coefficient with GA, bi-parietal diameter and transverse cerebellar diameter. Conclusions: The present data constitutes the first quantification of NPBI concentrations in amniotic fluid under physiological conditions. Correlations with GA and ultrasound fetal biometry suggest that NPBI may play a role in fetal growth. (C) 2005 The Canadian Society of Clinical Chemists. All rights reserved.}},
author = {{Gazzolo, D and Perrone, S and Paffetti, P and Longini, M and Vezzosi, P and Bruschettini, Matteo and Lituania, M and Buonocore, G}},
issn = {{1873-2933}},
keywords = {{stress; oxidative; pregnancy; ammotic fluid; fetus; non protein bound iron}},
language = {{eng}},
number = {{7}},
pages = {{674--677}},
publisher = {{Elsevier}},
series = {{Clinical Biochemistry}},
title = {{Non protein bound iron concentrations in amniotic fluid}},
url = {{http://dx.doi.org/10.1016/j.clinbiochem.2005.03.010}},
doi = {{10.1016/j.clinbiochem.2005.03.010}},
volume = {{38}},
year = {{2005}},
}