Direct reprogramming into interneurons : potential for brain repair
(2019) In Cellular and Molecular Life Sciences 76(20). p.3953-3967- Abstract
The brain tissue has only a limited capacity for generating new neurons. Therefore, to treat neurological diseases, there is a need of other cell sources for brain repair. Different sources of cells have been subject of intense research over the years, including cells from primary tissue, stem cell-derived cells and reprogrammed cells. As an alternative, direct reprogramming of resident brain cells into neurons is a recent approach that could provide an attractive method for treating brain injuries or diseases as it uses the patient’s own cells for generating novel neurons inside the brain. In vivo reprogramming is still in its early stages but holds great promise as an option for cell therapy. To date, both inhibitory and excitatory... (More)
The brain tissue has only a limited capacity for generating new neurons. Therefore, to treat neurological diseases, there is a need of other cell sources for brain repair. Different sources of cells have been subject of intense research over the years, including cells from primary tissue, stem cell-derived cells and reprogrammed cells. As an alternative, direct reprogramming of resident brain cells into neurons is a recent approach that could provide an attractive method for treating brain injuries or diseases as it uses the patient’s own cells for generating novel neurons inside the brain. In vivo reprogramming is still in its early stages but holds great promise as an option for cell therapy. To date, both inhibitory and excitatory neurons have been obtained via in vivo reprogramming, but the precise phenotype or functionality of these cells has not been analysed in detail in most of the studies. Recent data shows that in vivo reprogrammed neurons are able to functionally mature and integrate into the existing brain circuitry, and compose interneuron phenotypes that seem to correlate to their endogenous counterparts. Interneurons are of particular importance as they are essential in physiological brain function and when disturbed lead to several neurological disorders. In this review, we describe a comprehensive overview of the existing studies involving brain repair, including in vivo reprogramming, with a focus on interneurons, along with an overview on current efforts to generate interneurons for cell therapy for a number of neurological diseases.
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- author
- Pereira, Maria LU ; Birtele, Marcella LU and Rylander Ottosson, Daniella LU
- organization
-
- Stem Cell Center
- Department of Experimental Medical Science
- StemTherapy: National Initiative on Stem Cells for Regenerative Therapy
- Developmental and Regenerative Neurobiology (research group)
- MultiPark: Multidisciplinary research focused on Parkinson´s disease
- Regenerative Neurophysiology (research group)
- publishing date
- 2019
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Cell therapy, Dopamine, ESCs, iNs, Intracerebral injections, iPSC, Mice, Neurodegenerative diseases, Neuronal conversion, Neuropsychiatric disorders, Parvalbumin, Transdifferentiation, Viral injections
- in
- Cellular and Molecular Life Sciences
- volume
- 76
- issue
- 20
- pages
- 3953 - 3967
- publisher
- Birkhäuser Verlag
- external identifiers
-
- pmid:31250034
- scopus:85068206654
- ISSN
- 1420-682X
- DOI
- 10.1007/s00018-019-03193-3
- language
- English
- LU publication?
- yes
- id
- 7dc5712c-ba88-403e-bd2a-f772274e4219
- date added to LUP
- 2019-07-10 15:10:31
- date last changed
- 2024-06-25 23:27:40
@article{7dc5712c-ba88-403e-bd2a-f772274e4219, abstract = {{<p>The brain tissue has only a limited capacity for generating new neurons. Therefore, to treat neurological diseases, there is a need of other cell sources for brain repair. Different sources of cells have been subject of intense research over the years, including cells from primary tissue, stem cell-derived cells and reprogrammed cells. As an alternative, direct reprogramming of resident brain cells into neurons is a recent approach that could provide an attractive method for treating brain injuries or diseases as it uses the patient’s own cells for generating novel neurons inside the brain. In vivo reprogramming is still in its early stages but holds great promise as an option for cell therapy. To date, both inhibitory and excitatory neurons have been obtained via in vivo reprogramming, but the precise phenotype or functionality of these cells has not been analysed in detail in most of the studies. Recent data shows that in vivo reprogrammed neurons are able to functionally mature and integrate into the existing brain circuitry, and compose interneuron phenotypes that seem to correlate to their endogenous counterparts. Interneurons are of particular importance as they are essential in physiological brain function and when disturbed lead to several neurological disorders. In this review, we describe a comprehensive overview of the existing studies involving brain repair, including in vivo reprogramming, with a focus on interneurons, along with an overview on current efforts to generate interneurons for cell therapy for a number of neurological diseases.</p>}}, author = {{Pereira, Maria and Birtele, Marcella and Rylander Ottosson, Daniella}}, issn = {{1420-682X}}, keywords = {{Cell therapy; Dopamine; ESCs; iNs; Intracerebral injections; iPSC; Mice; Neurodegenerative diseases; Neuronal conversion; Neuropsychiatric disorders; Parvalbumin; Transdifferentiation; Viral injections}}, language = {{eng}}, number = {{20}}, pages = {{3953--3967}}, publisher = {{Birkhäuser Verlag}}, series = {{Cellular and Molecular Life Sciences}}, title = {{Direct reprogramming into interneurons : potential for brain repair}}, url = {{http://dx.doi.org/10.1007/s00018-019-03193-3}}, doi = {{10.1007/s00018-019-03193-3}}, volume = {{76}}, year = {{2019}}, }