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Multi-parameter mapping (MPM) of relaxation (R1, R2*), proton density (PD) and magnetization transfer saturation (MT) at 3T: a multi-center dual-vendor reproducibility and repeatability study

Leutritz, Tobias ; Seif, Maryam ; Helms, Gunther LU orcid ; Samson, Rebecca S ; Curt, Armin ; Freund, Patrick and Weiskopf, Nikolaus (2020) In Human Brain Mapping 41(15). p.4232-4247
Abstract
Multicenter clinical and quantitative magnetic resonance imaging (qMRI) studies require a high degree of reproducibility across different sites and scanner manufacturers, as well as time points. We therefore implemented a multiparameter mapping (MPM) protocol based on vendor's product sequences and demonstrate its repeatability and reproducibility for whole‐brain coverage. Within ~20 min, four MPM metrics (magnetization transfer saturation [MT], proton density [PD], longitudinal [R1], and effective transverse [R2*] relaxation rates) were measured using an optimized 1 mm isotropic resolution protocol on six 3 T MRI scanners from two different vendors. The same five healthy participants underwent two scanning sessions, on the same scanner,... (More)
Multicenter clinical and quantitative magnetic resonance imaging (qMRI) studies require a high degree of reproducibility across different sites and scanner manufacturers, as well as time points. We therefore implemented a multiparameter mapping (MPM) protocol based on vendor's product sequences and demonstrate its repeatability and reproducibility for whole‐brain coverage. Within ~20 min, four MPM metrics (magnetization transfer saturation [MT], proton density [PD], longitudinal [R1], and effective transverse [R2*] relaxation rates) were measured using an optimized 1 mm isotropic resolution protocol on six 3 T MRI scanners from two different vendors. The same five healthy participants underwent two scanning sessions, on the same scanner, at each site. MPM metrics were calculated using the hMRI‐toolbox. To account for different MT pulses used by each vendor, we linearly scaled the MT values to harmonize them across vendors. To determine longitudinal repeatability and inter‐site comparability, the intra‐site (i.e., scan‐rescan experiment) coefficient of variation (CoV), inter‐site CoV, and bias across sites were estimated. For MT, R1, and PD, the intra‐ and inter‐site CoV was between 4 and 10% across sites and scan time points for intracranial gray and white matter. A higher intra‐site CoV (16%) was observed in R2* maps. The inter‐site bias was below 5% for all parameters. In conclusion, the MPM protocol yielded reliable quantitative maps at high resolution with a short acquisition time. The high reproducibility of MPM metrics across sites and scan time points combined with its tissue microstructure sensitivity facilitates longitudinal multicenter imaging studies targeting microstructural changes, for example, as a quantitative MRI biomarker for interventional clinical trials. (Less)
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author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Human Brain Mapping
volume
41
issue
15
pages
16 pages
publisher
Wiley-Blackwell
external identifiers
  • scopus:85087652976
  • pmid:32639104
ISSN
1065-9471
DOI
10.1002/hbm.25122
language
English
LU publication?
yes
id
7eb8136d-8bf2-4579-84f8-cb1fd4b23bc5
date added to LUP
2020-07-09 00:17:06
date last changed
2022-04-18 23:25:50
@article{7eb8136d-8bf2-4579-84f8-cb1fd4b23bc5,
  abstract     = {{Multicenter clinical and quantitative magnetic resonance imaging (qMRI) studies require a high degree of reproducibility across different sites and scanner manufacturers, as well as time points. We therefore implemented a multiparameter mapping (MPM) protocol based on vendor's product sequences and demonstrate its repeatability and reproducibility for whole‐brain coverage. Within ~20 min, four MPM metrics (magnetization transfer saturation [MT], proton density [PD], longitudinal [R1], and effective transverse [R2*] relaxation rates) were measured using an optimized 1 mm isotropic resolution protocol on six 3 T MRI scanners from two different vendors. The same five healthy participants underwent two scanning sessions, on the same scanner, at each site. MPM metrics were calculated using the hMRI‐toolbox. To account for different MT pulses used by each vendor, we linearly scaled the MT values to harmonize them across vendors. To determine longitudinal repeatability and inter‐site comparability, the intra‐site (i.e., scan‐rescan experiment) coefficient of variation (CoV), inter‐site CoV, and bias across sites were estimated. For MT, R1, and PD, the intra‐ and inter‐site CoV was between 4 and 10% across sites and scan time points for intracranial gray and white matter. A higher intra‐site CoV (16%) was observed in R2* maps. The inter‐site bias was below 5% for all parameters. In conclusion, the MPM protocol yielded reliable quantitative maps at high resolution with a short acquisition time. The high reproducibility of MPM metrics across sites and scan time points combined with its tissue microstructure sensitivity facilitates longitudinal multicenter imaging studies targeting microstructural changes, for example, as a quantitative MRI biomarker for interventional clinical trials.}},
  author       = {{Leutritz, Tobias and Seif, Maryam and Helms, Gunther and Samson, Rebecca S and Curt, Armin and Freund, Patrick and Weiskopf, Nikolaus}},
  issn         = {{1065-9471}},
  language     = {{eng}},
  month        = {{10}},
  number       = {{15}},
  pages        = {{4232--4247}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{Human Brain Mapping}},
  title        = {{Multi-parameter mapping (MPM) of relaxation (R1, R2*), proton density (PD) and magnetization transfer saturation (MT) at 3T: a multi-center dual-vendor reproducibility and repeatability study}},
  url          = {{http://dx.doi.org/10.1002/hbm.25122}},
  doi          = {{10.1002/hbm.25122}},
  volume       = {{41}},
  year         = {{2020}},
}