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Review and perspectives on the structure–function relationships of the gag subunits of feline immunodeficiency virus

Long, Mathieu LU ; Toesca, Johan and Guillon, Christophe (2021) In Pathogens 10(11).
Abstract

The Gag polyprotein is implied in the budding as well as the establishment of the supramolecular architecture of infectious retroviral particles. It is also involved in the early phases of the replication of retroviruses by protecting and transporting the viral genome towards the nucleus of the infected cell until its integration in the host genome. Therefore, understanding the structure– function relationships of the Gag subunits is crucial as each of them can represent a therapeutic target. Though the field has been explored for some time in the area of Human Immunodeficiency Virus (HIV), it is only in the last decade that structural data on Feline Immunodeficiency Virus (FIV) Gag subunits have emerged. As FIV is an important... (More)

The Gag polyprotein is implied in the budding as well as the establishment of the supramolecular architecture of infectious retroviral particles. It is also involved in the early phases of the replication of retroviruses by protecting and transporting the viral genome towards the nucleus of the infected cell until its integration in the host genome. Therefore, understanding the structure– function relationships of the Gag subunits is crucial as each of them can represent a therapeutic target. Though the field has been explored for some time in the area of Human Immunodeficiency Virus (HIV), it is only in the last decade that structural data on Feline Immunodeficiency Virus (FIV) Gag subunits have emerged. As FIV is an important veterinary issue, both in domestic cats and endangered feline species, such data are of prime importance for the development of anti-FIV molecules targeting Gag. This review will focus on the recent advances and perspectives on the structure–function relationships of each subunit of the FIV Gag polyprotein.

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author
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organization
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type
Contribution to journal
publication status
published
subject
keywords
Capsid, Feline Immunodeficiency Virus, FIV, Gag, HIV, Human Immunodeficiency Virus, Late domain, Matrix, Nucleocapsid, Structure
in
Pathogens
volume
10
issue
11
article number
1502
publisher
MDPI AG
external identifiers
  • pmid:34832657
  • scopus:85119681699
ISSN
2076-0817
DOI
10.3390/pathogens10111502
language
English
LU publication?
yes
id
7f8b80d5-2a68-4e70-9234-c6d343d6c4f6
date added to LUP
2021-12-03 14:38:35
date last changed
2024-07-14 00:30:39
@article{7f8b80d5-2a68-4e70-9234-c6d343d6c4f6,
  abstract     = {{<p>The Gag polyprotein is implied in the budding as well as the establishment of the supramolecular architecture of infectious retroviral particles. It is also involved in the early phases of the replication of retroviruses by protecting and transporting the viral genome towards the nucleus of the infected cell until its integration in the host genome. Therefore, understanding the structure– function relationships of the Gag subunits is crucial as each of them can represent a therapeutic target. Though the field has been explored for some time in the area of Human Immunodeficiency Virus (HIV), it is only in the last decade that structural data on Feline Immunodeficiency Virus (FIV) Gag subunits have emerged. As FIV is an important veterinary issue, both in domestic cats and endangered feline species, such data are of prime importance for the development of anti-FIV molecules targeting Gag. This review will focus on the recent advances and perspectives on the structure–function relationships of each subunit of the FIV Gag polyprotein.</p>}},
  author       = {{Long, Mathieu and Toesca, Johan and Guillon, Christophe}},
  issn         = {{2076-0817}},
  keywords     = {{Capsid; Feline Immunodeficiency Virus; FIV; Gag; HIV; Human Immunodeficiency Virus; Late domain; Matrix; Nucleocapsid; Structure}},
  language     = {{eng}},
  number       = {{11}},
  publisher    = {{MDPI AG}},
  series       = {{Pathogens}},
  title        = {{Review and perspectives on the structure–function relationships of the gag subunits of feline immunodeficiency virus}},
  url          = {{http://dx.doi.org/10.3390/pathogens10111502}},
  doi          = {{10.3390/pathogens10111502}},
  volume       = {{10}},
  year         = {{2021}},
}