Epigenetic alterations in human liver from subjects with type 2 diabetes in parallel with reduced folate levels.
(2015) In Journal of Clinical Endocrinology and Metabolism 100(11). p.1491-1501- Abstract
- Epigenetic variation may contribute to the development of complex metabolic diseases such as type 2 diabetes (T2D). Hepatic insulin resistance is a hallmark of T2D. However, it remains unknown if epigenetic alterations take place in the liver from diabetic subjects. Therefore, we investigated the genome-wide DNA methylation pattern in the liver from subjects with T2D and non-diabetic controls and related epigenetic alterations to gene expression and circulating folate levels.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/8034507
- author
- Nilsson, Emma A LU ; Matte, Ashok ; Perfilyev, Alexander LU ; de Mello, Vanessa D ; Käkelä, Pirjo ; Pihlajamäki, Jussi and Ling, Charlotte LU
- organization
- publishing date
- 2015
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Clinical Endocrinology and Metabolism
- volume
- 100
- issue
- 11
- pages
- 1491 - 1501
- publisher
- Oxford University Press
- external identifiers
-
- pmid:26418287
- wos:000364925700023
- scopus:84958673442
- pmid:26418287
- ISSN
- 1945-7197
- DOI
- 10.1210/jc.2015-3204
- language
- English
- LU publication?
- yes
- id
- 9b192333-b505-4b12-acf4-5e88c7f6277c (old id 8034507)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/26418287?dopt=Abstract
- date added to LUP
- 2016-04-01 10:32:54
- date last changed
- 2023-03-17 06:27:02
@article{9b192333-b505-4b12-acf4-5e88c7f6277c, abstract = {{Epigenetic variation may contribute to the development of complex metabolic diseases such as type 2 diabetes (T2D). Hepatic insulin resistance is a hallmark of T2D. However, it remains unknown if epigenetic alterations take place in the liver from diabetic subjects. Therefore, we investigated the genome-wide DNA methylation pattern in the liver from subjects with T2D and non-diabetic controls and related epigenetic alterations to gene expression and circulating folate levels.}}, author = {{Nilsson, Emma A and Matte, Ashok and Perfilyev, Alexander and de Mello, Vanessa D and Käkelä, Pirjo and Pihlajamäki, Jussi and Ling, Charlotte}}, issn = {{1945-7197}}, language = {{eng}}, number = {{11}}, pages = {{1491--1501}}, publisher = {{Oxford University Press}}, series = {{Journal of Clinical Endocrinology and Metabolism}}, title = {{Epigenetic alterations in human liver from subjects with type 2 diabetes in parallel with reduced folate levels.}}, url = {{http://dx.doi.org/10.1210/jc.2015-3204}}, doi = {{10.1210/jc.2015-3204}}, volume = {{100}}, year = {{2015}}, }