Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Role of ursolic acid in preventing gastrointestinal cancer: recent trends and future perspectives

Chauhan, Abhishek ; Pathak, Vinay Mohan ; Yadav, Mnika ; Chauhan, Rita ; Babu, Neelesh ; Chowdhary, Manish ; Ranjan, Anuj ; Mathkor, Darin Mansor ; Haque, Shafiul and Singh Tuli, Hardeep , et al. (2024) In Frontiers in Pharmacology 15. p.01-12
Abstract
Gastrointestinal malignancies are one of the major worldwide health concerns. In the present review, we have assessed the plausible therapeutic implication of Ursolic Acid (UA) against gastrointestinal cancer. By modulating several signaling pathways critical in cancer development, UA could offer anti-inflammatory, anti-proliferative, and anti-metastatic properties. However, being of low oral bioavailability and poor permeability, its clinical value is restricted. To deliver and protect the drug, liposomes and polymer micelles are two UA nanoformulations that can effectively increase medicine stability. The use of UA for treating cancers is safe and appropriate with low toxicity characteristics and a predictable pharmacokinetic profile.... (More)
Gastrointestinal malignancies are one of the major worldwide health concerns. In the present review, we have assessed the plausible therapeutic implication of Ursolic Acid (UA) against gastrointestinal cancer. By modulating several signaling pathways critical in cancer development, UA could offer anti-inflammatory, anti-proliferative, and anti-metastatic properties. However, being of low oral bioavailability and poor permeability, its clinical value is restricted. To deliver and protect the drug, liposomes and polymer micelles are two UA nanoformulations that can effectively increase medicine stability. The use of UA for treating cancers is safe and appropriate with low toxicity characteristics and a predictable pharmacokinetic profile. Although the bioavailability of UA is limited, its nanoformulations could emerge as an alternative to enhance its efficacy in treating GI cancers. Further optimization and validation in the clinical trials are necessary. The combination of molecular profiling with nanoparticle-based drug delivery technologies holds the potential for bringing UA to maximum efficacy, looking for good prospects with GI cancer treatment. (Less)
Please use this url to cite or link to this publication:
author
; ; ; ; ; ; ; ; and , et al. (More)
; ; ; ; ; ; ; ; ; ; and (Less)
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Frontiers in Pharmacology
volume
15
article number
1405497
pages
01 - 12
publisher
Frontiers Media S. A.
external identifiers
  • scopus:85200660217
ISSN
1663-9812
DOI
10.3389/fphar.2024.1405497
language
English
LU publication?
yes
id
80fd508f-64b3-48d7-98e0-a893d7b79c9d
date added to LUP
2024-10-04 18:24:11
date last changed
2025-06-01 01:18:21
@article{80fd508f-64b3-48d7-98e0-a893d7b79c9d,
  abstract     = {{Gastrointestinal malignancies are one of the major worldwide health concerns. In the present review, we have assessed the plausible therapeutic implication of Ursolic Acid (UA) against gastrointestinal cancer. By modulating several signaling pathways critical in cancer development, UA could offer anti-inflammatory, anti-proliferative, and anti-metastatic properties. However, being of low oral bioavailability and poor permeability, its clinical value is restricted. To deliver and protect the drug, liposomes and polymer micelles are two UA nanoformulations that can effectively increase medicine stability. The use of UA for treating cancers is safe and appropriate with low toxicity characteristics and a predictable pharmacokinetic profile. Although the bioavailability of UA is limited, its nanoformulations could emerge as an alternative to enhance its efficacy in treating GI cancers. Further optimization and validation in the clinical trials are necessary. The combination of molecular profiling with nanoparticle-based drug delivery technologies holds the potential for bringing UA to maximum efficacy, looking for good prospects with GI cancer treatment.}},
  author       = {{Chauhan, Abhishek and Pathak, Vinay Mohan and Yadav, Mnika and Chauhan, Rita and Babu, Neelesh and Chowdhary, Manish and Ranjan, Anuj and Mathkor, Darin Mansor and Haque, Shafiul and Singh Tuli, Hardeep and Ramniwas, Seema and Yadav, Vikas}},
  issn         = {{1663-9812}},
  language     = {{eng}},
  month        = {{07}},
  pages        = {{01--12}},
  publisher    = {{Frontiers Media S. A.}},
  series       = {{Frontiers in Pharmacology}},
  title        = {{Role of ursolic acid in preventing gastrointestinal cancer: recent trends and future perspectives}},
  url          = {{http://dx.doi.org/10.3389/fphar.2024.1405497}},
  doi          = {{10.3389/fphar.2024.1405497}},
  volume       = {{15}},
  year         = {{2024}},
}