BCOR internal tandem duplication and YWHAE-NUTM2B/E fusion are mutually exclusive events in clear cell sarcoma of the kidney.
Karlsson, Jenny LU ; Valind, Anders LU
and Gisselsson Nord, David
LU
(2016)
In Genes, Chromosomes and Cancer
55(2).
p.120-123
- Abstract
- Clear cell sarcoma of the kidney (CCSK) is the second most common pediatric renal tumor. Two recurrent genetic aberrations have been described in CCSK. One is a fusion of YWHAE and NUTM2B/E, the other is an internal tandem duplication (ITD) in the BCOR gene. Here it is shown that YWHAE-NUTM2B/E fusion and the BCOR ITD are mutually exclusive events and activated different downstream signaling systems. This has important diagnostic implications and opens up for further mechanistic studies of CCSK pathogenesis. © 2015 Wiley Periodicals, Inc.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/8148592
- author
- Karlsson, Jenny
LU
; Valind, Anders
LU
and Gisselsson Nord, David
LU
- organization
- publishing date
- 2016
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Genes, Chromosomes and Cancer
- volume
- 55
- issue
- 2
- pages
- 120 - 123
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- pmid:26493387
- wos:000368259600002
- scopus:84954393741
- pmid:26493387
- ISSN
- 1045-2257
- DOI
- 10.1002/gcc.22316
- language
- English
- LU publication?
- yes
- id
- 36c6581d-e55c-4944-b15d-cea0b37b79e4 (old id 8148592)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/26493387?dopt=Abstract
- date added to LUP
- 2016-04-01 11:04:58
- date last changed
- 2022-04-12 20:16:03
@article{36c6581d-e55c-4944-b15d-cea0b37b79e4,
abstract = {{Clear cell sarcoma of the kidney (CCSK) is the second most common pediatric renal tumor. Two recurrent genetic aberrations have been described in CCSK. One is a fusion of YWHAE and NUTM2B/E, the other is an internal tandem duplication (ITD) in the BCOR gene. Here it is shown that YWHAE-NUTM2B/E fusion and the BCOR ITD are mutually exclusive events and activated different downstream signaling systems. This has important diagnostic implications and opens up for further mechanistic studies of CCSK pathogenesis. © 2015 Wiley Periodicals, Inc.}},
author = {{Karlsson, Jenny and Valind, Anders and Gisselsson Nord, David}},
issn = {{1045-2257}},
language = {{eng}},
number = {{2}},
pages = {{120--123}},
publisher = {{John Wiley & Sons Inc.}},
series = {{Genes, Chromosomes and Cancer}},
title = {{BCOR internal tandem duplication and YWHAE-NUTM2B/E fusion are mutually exclusive events in clear cell sarcoma of the kidney.}},
url = {{http://dx.doi.org/10.1002/gcc.22316}},
doi = {{10.1002/gcc.22316}},
volume = {{55}},
year = {{2016}},
}