The effect of schizophrenia on length of in-hospital stay and major adverse cardiac events following acute coronary syndrome in Denmark
(2018) In European Heart Journal 39(1).- Abstract
- Background: The relationship between schizophrenia and acute coronary syndrome (ACS) has already been established. This study aims to investigate the difference in length of in-hospital stay (LoS) between a population with schizophrenia and a psychiatric healthy control (PHC) population following admission for a first ACS.
Methods: Data for this retrospective study was collected from three nationwide databases in Denmark; The Danish Civil Registration System, the National Patient register and the Danish Psychiatric Central Register. Patients diagnosed with a first ACS (unstable angina ICD-10 I20.0, NSTEMI ICD-10 I21.4 and STEMI ICD-10 I21.0-I21.3) between 2000–2014 were identified and screened for an additional diagnosis of narrow... (More) - Background: The relationship between schizophrenia and acute coronary syndrome (ACS) has already been established. This study aims to investigate the difference in length of in-hospital stay (LoS) between a population with schizophrenia and a psychiatric healthy control (PHC) population following admission for a first ACS.
Methods: Data for this retrospective study was collected from three nationwide databases in Denmark; The Danish Civil Registration System, the National Patient register and the Danish Psychiatric Central Register. Patients diagnosed with a first ACS (unstable angina ICD-10 I20.0, NSTEMI ICD-10 I21.4 and STEMI ICD-10 I21.0-I21.3) between 2000–2014 were identified and screened for an additional diagnosis of narrow spectrum schizophrenia ICD-10 F20. The patients were matched 1:2 to a PHC population on gender, age and year of first ACS diagnosis. The LoS, as well as the effect of schizophrenia on major adverse cardiac events (MACE: stroke, reinfarction and all-cause mortality) was investigated using cox regression analyses.
Results: A total of 1,572 patients were analysed (schizophrenia: n=524), 65.27% of the population were males and the mean age was 61.13 years. There was no difference in LoS (p>0.05) between the populations. Patients with schizophrenia had a higher prevalence of cardiac risk factors such as anemia and diabetes mellitus. Having schizophrenia had a significant effect on stroke (HR 1.47, 95% CI: 1.29–1.68)) and all-cause mortality rates (HR 2.69, 95% CI: 2.25–3.20). The results for the individual ACS diagnoses can be found in Table 1. (Less)
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https://lup.lub.lu.se/record/81fd32da-694e-4b7c-82aa-24eb9fa168c5
- author
- Attar, Rubina LU ; Valentin, J B ; Aagaard, J and Jensen, S E
- publishing date
- 2018-08
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- acute coronary syndromes, cardiac event, schizophrenia
- in
- European Heart Journal
- volume
- 39
- issue
- 1
- publisher
- Oxford University Press
- ISSN
- 1522-9645
- DOI
- 10.1093/eurheartj/ehy563.P4431
- language
- English
- LU publication?
- no
- id
- 81fd32da-694e-4b7c-82aa-24eb9fa168c5
- date added to LUP
- 2019-04-02 13:22:44
- date last changed
- 2020-11-12 02:29:06
@misc{81fd32da-694e-4b7c-82aa-24eb9fa168c5, abstract = {{Background: The relationship between schizophrenia and acute coronary syndrome (ACS) has already been established. This study aims to investigate the difference in length of in-hospital stay (LoS) between a population with schizophrenia and a psychiatric healthy control (PHC) population following admission for a first ACS.<br> <br> Methods: Data for this retrospective study was collected from three nationwide databases in Denmark; The Danish Civil Registration System, the National Patient register and the Danish Psychiatric Central Register. Patients diagnosed with a first ACS (unstable angina ICD-10 I20.0, NSTEMI ICD-10 I21.4 and STEMI ICD-10 I21.0-I21.3) between 2000–2014 were identified and screened for an additional diagnosis of narrow spectrum schizophrenia ICD-10 F20. The patients were matched 1:2 to a PHC population on gender, age and year of first ACS diagnosis. The LoS, as well as the effect of schizophrenia on major adverse cardiac events (MACE: stroke, reinfarction and all-cause mortality) was investigated using cox regression analyses.<br> <br> Results: A total of 1,572 patients were analysed (schizophrenia: n=524), 65.27% of the population were males and the mean age was 61.13 years. There was no difference in LoS (p>0.05) between the populations. Patients with schizophrenia had a higher prevalence of cardiac risk factors such as anemia and diabetes mellitus. Having schizophrenia had a significant effect on stroke (HR 1.47, 95% CI: 1.29–1.68)) and all-cause mortality rates (HR 2.69, 95% CI: 2.25–3.20). The results for the individual ACS diagnoses can be found in Table 1.}}, author = {{Attar, Rubina and Valentin, J B and Aagaard, J and Jensen, S E}}, issn = {{1522-9645}}, keywords = {{acute coronary syndromes; cardiac event; schizophrenia}}, language = {{eng}}, note = {{Conference Abstract}}, number = {{1}}, publisher = {{Oxford University Press}}, series = {{European Heart Journal}}, title = {{The effect of schizophrenia on length of in-hospital stay and major adverse cardiac events following acute coronary syndrome in Denmark}}, url = {{http://dx.doi.org/10.1093/eurheartj/ehy563.P4431}}, doi = {{10.1093/eurheartj/ehy563.P4431}}, volume = {{39}}, year = {{2018}}, }