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Virtual non-contrast images in photon-counting computed tomography: impact of different contrast phases

Gadsbøll, Eva Laurin LU ; Aurumskjöld, Marie-Louise LU ; Holmquist, Fredrik LU and Baubeta, Erik LU orcid (2024) In Acta Radiologica
Abstract
Background
Photon-counting computed tomography (PCCT) enables new ways of image reconstruction, e.g. material decomposition and creation of virtual non-contrast (VNC) series with higher resolution and lower radiation dose than standard computed tomography (CT). Clinical experiences of this are limited.
Purpose
To compare true non-contrast (TNC) series with VNC series derived from non-enhanced (VNCu), arterial phase (VNCa) and portal venous phase (VNCv) in clinically approved PCCT.
Material and Methods
A total of 45 clinical, tri-phasic abdominal CT scans from the PCCT Naetom Alpha, between February 2022 and November 2022, were retrospectively assessed. Placing a region of interest in six different locations in each VNC... (More)
Background
Photon-counting computed tomography (PCCT) enables new ways of image reconstruction, e.g. material decomposition and creation of virtual non-contrast (VNC) series with higher resolution and lower radiation dose than standard computed tomography (CT). Clinical experiences of this are limited.
Purpose
To compare true non-contrast (TNC) series with VNC series derived from non-enhanced (VNCu), arterial phase (VNCa) and portal venous phase (VNCv) in clinically approved PCCT.
Material and Methods
A total of 45 clinical, tri-phasic abdominal CT scans from the PCCT Naetom Alpha, between February 2022 and November 2022, were retrospectively assessed. Placing a region of interest in six different locations in each VNC series – right liver parenchyma, left liver parenchyma, spleen, aorta, erector spinae muscle, and in the subcutaneous fat – absolute Hounsfield values (HU) and standard deviations (SD) were collected. Differences in HU (ΔHU) were compared and statistically analyzed.
Results
Statistically significant differences between VNC and TNC were seen in all measurements, with the largest difference in the subcutaneous fat and the smallest difference in the erector spinae muscle. Only small differences were seen between VNCa and VNCv, where the largest differences were seen in the left and right liver lobes.
Conclusion
VNC images from the first-generation clinically approved PCCT showed a significant difference between VNC and TNC images. The differences vary with the type of tissue. Only small differences were seen depending from which contrast phase the VNC was derived. (Less)
Please use this url to cite or link to this publication:
author
; ; and
organization
publishing date
type
Contribution to journal
publication status
epub
subject
in
Acta Radiologica
publisher
SAGE Publications
external identifiers
  • pmid:39140849
ISSN
1600-0455
DOI
10.1177/02841851241271202
language
English
LU publication?
yes
id
82c43cef-62f7-487a-9347-373e00ff8721
date added to LUP
2024-08-15 16:25:07
date last changed
2024-08-16 06:53:48
@article{82c43cef-62f7-487a-9347-373e00ff8721,
  abstract     = {{Background<br/>Photon-counting computed tomography (PCCT) enables new ways of image reconstruction, e.g. material decomposition and creation of virtual non-contrast (VNC) series with higher resolution and lower radiation dose than standard computed tomography (CT). Clinical experiences of this are limited.<br/>Purpose<br/>To compare true non-contrast (TNC) series with VNC series derived from non-enhanced (VNCu), arterial phase (VNCa) and portal venous phase (VNCv) in clinically approved PCCT.<br/>Material and Methods<br/>A total of 45 clinical, tri-phasic abdominal CT scans from the PCCT Naetom Alpha, between February 2022 and November 2022, were retrospectively assessed. Placing a region of interest in six different locations in each VNC series – right liver parenchyma, left liver parenchyma, spleen, aorta, erector spinae muscle, and in the subcutaneous fat – absolute Hounsfield values (HU) and standard deviations (SD) were collected. Differences in HU (ΔHU) were compared and statistically analyzed.<br/>Results<br/>Statistically significant differences between VNC and TNC were seen in all measurements, with the largest difference in the subcutaneous fat and the smallest difference in the erector spinae muscle. Only small differences were seen between VNCa and VNCv, where the largest differences were seen in the left and right liver lobes.<br/>Conclusion<br/>VNC images from the first-generation clinically approved PCCT showed a significant difference between VNC and TNC images. The differences vary with the type of tissue. Only small differences were seen depending from which contrast phase the VNC was derived.}},
  author       = {{Gadsbøll, Eva Laurin and Aurumskjöld, Marie-Louise and Holmquist, Fredrik and Baubeta, Erik}},
  issn         = {{1600-0455}},
  language     = {{eng}},
  publisher    = {{SAGE Publications}},
  series       = {{Acta Radiologica}},
  title        = {{Virtual non-contrast images in  photon-counting computed tomography: impact of different contrast phases}},
  url          = {{http://dx.doi.org/10.1177/02841851241271202}},
  doi          = {{10.1177/02841851241271202}},
  year         = {{2024}},
}