Assessing accuracy in linkage analysis by means of confidence regions
(2002) In Preprint without journal information- Abstract
- When statistical linkage to a certain chromosomal region has been found, it is of interest to develop methods which quantify the accuracy with which the disease locus can be mapped. In this paper, we investigate the performance of three different types of confidence regions with asymptotically correct coverage probability as the number of pedigrees grows. Our setup is that of a saturated map of marker data. We show that the expected length of the confidence region is inversely proportional to the square of the noncentrality parameter and to a certain normalized slope-to-noise ratio. Our investigations reveal that testing performance criteria (such as the power to detect linkage) can be quite different from estimation based performance... (More)
- When statistical linkage to a certain chromosomal region has been found, it is of interest to develop methods which quantify the accuracy with which the disease locus can be mapped. In this paper, we investigate the performance of three different types of confidence regions with asymptotically correct coverage probability as the number of pedigrees grows. Our setup is that of a saturated map of marker data. We show that the expected length of the confidence region is inversely proportional to the square of the noncentrality parameter and to a certain normalized slope-to-noise ratio. Our investigations reveal that testing performance criteria (such as the power to detect linkage) can be quite different from estimation based performance criteria (such as the expected length of a confidence region). (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/830022
- author
- Hössjer, Ola LU
- organization
- publishing date
- 2002
- type
- Contribution to journal
- publication status
- unpublished
- subject
- in
- Preprint without journal information
- issue
- 2002:17
- publisher
- Manne Siegbahn Institute
- ISSN
- 0348-7911
- language
- English
- LU publication?
- yes
- id
- 14a08faa-e9cb-4fdc-b8d2-a5e3cdfa3b9e (old id 830022)
- date added to LUP
- 2016-04-04 09:30:00
- date last changed
- 2018-11-21 20:53:33
@article{14a08faa-e9cb-4fdc-b8d2-a5e3cdfa3b9e, abstract = {{When statistical linkage to a certain chromosomal region has been found, it is of interest to develop methods which quantify the accuracy with which the disease locus can be mapped. In this paper, we investigate the performance of three different types of confidence regions with asymptotically correct coverage probability as the number of pedigrees grows. Our setup is that of a saturated map of marker data. We show that the expected length of the confidence region is inversely proportional to the square of the noncentrality parameter and to a certain normalized slope-to-noise ratio. Our investigations reveal that testing performance criteria (such as the power to detect linkage) can be quite different from estimation based performance criteria (such as the expected length of a confidence region).}}, author = {{Hössjer, Ola}}, issn = {{0348-7911}}, language = {{eng}}, number = {{2002:17}}, publisher = {{Manne Siegbahn Institute}}, series = {{Preprint without journal information}}, title = {{Assessing accuracy in linkage analysis by means of confidence regions}}, year = {{2002}}, }