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von Willebrand factor D and EGF domains is an evolutionarily conserved and required feature of blastemas capable of multitissue appendage regeneration

Leigh, Nicholas D LU orcid ; Sessa, Sofia ; Dragalzew, Aline C ; Payzin-Dogru, Duygu ; Sousa, Josane F ; Aggouras, Anthony N ; Johnson, Kimberly ; Dunlap, Garrett S ; Haas, Brian J and Levin, Michael , et al. (2020) In Evolution & Development 22(4). p.297-311
Abstract

Regenerative ability varies tremendously across species. A common feature of regeneration of appendages such as limbs, fins, antlers, and tails is the formation of a blastema-a transient structure that houses a pool of progenitor cells that can regenerate the missing tissue. We have identified the expression of von Willebrand factor D and EGF domains (vwde) as a common feature of blastemas capable of regenerating limbs and fins in a variety of highly regenerative species, including axolotl (Ambystoma mexicanum), lungfish (Lepidosiren paradoxa), and Polpyterus (Polypterus senegalus). Further, vwde expression is tightly linked to the ability to regenerate appendages in Xenopus laevis. Functional experiments demonstrate a requirement for... (More)

Regenerative ability varies tremendously across species. A common feature of regeneration of appendages such as limbs, fins, antlers, and tails is the formation of a blastema-a transient structure that houses a pool of progenitor cells that can regenerate the missing tissue. We have identified the expression of von Willebrand factor D and EGF domains (vwde) as a common feature of blastemas capable of regenerating limbs and fins in a variety of highly regenerative species, including axolotl (Ambystoma mexicanum), lungfish (Lepidosiren paradoxa), and Polpyterus (Polypterus senegalus). Further, vwde expression is tightly linked to the ability to regenerate appendages in Xenopus laevis. Functional experiments demonstrate a requirement for vwde in regeneration and indicate that Vwde is a potent growth factor in the blastema. These data identify a key role for vwde in regenerating blastemas and underscore the power of an evolutionarily informed approach for identifying conserved genetic components of regeneration.

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publishing date
type
Contribution to journal
publication status
published
subject
in
Evolution & Development
volume
22
issue
4
pages
297 - 311
publisher
Wiley-Blackwell
external identifiers
  • pmid:32163674
  • scopus:85081387001
ISSN
1525-142X
DOI
10.1111/ede.12332
language
English
LU publication?
no
additional info
© 2020 The Authors. Evolution & Development published by Wiley Periodicals, Inc.
id
8379571e-b21e-40c9-afec-523eed247dce
date added to LUP
2020-04-27 17:29:09
date last changed
2024-10-03 00:24:43
@article{8379571e-b21e-40c9-afec-523eed247dce,
  abstract     = {{<p>Regenerative ability varies tremendously across species. A common feature of regeneration of appendages such as limbs, fins, antlers, and tails is the formation of a blastema-a transient structure that houses a pool of progenitor cells that can regenerate the missing tissue. We have identified the expression of von Willebrand factor D and EGF domains (vwde) as a common feature of blastemas capable of regenerating limbs and fins in a variety of highly regenerative species, including axolotl (Ambystoma mexicanum), lungfish (Lepidosiren paradoxa), and Polpyterus (Polypterus senegalus). Further, vwde expression is tightly linked to the ability to regenerate appendages in Xenopus laevis. Functional experiments demonstrate a requirement for vwde in regeneration and indicate that Vwde is a potent growth factor in the blastema. These data identify a key role for vwde in regenerating blastemas and underscore the power of an evolutionarily informed approach for identifying conserved genetic components of regeneration.</p>}},
  author       = {{Leigh, Nicholas D and Sessa, Sofia and Dragalzew, Aline C and Payzin-Dogru, Duygu and Sousa, Josane F and Aggouras, Anthony N and Johnson, Kimberly and Dunlap, Garrett S and Haas, Brian J and Levin, Michael and Schneider, Igor and Whited, Jessica L}},
  issn         = {{1525-142X}},
  language     = {{eng}},
  month        = {{03}},
  number       = {{4}},
  pages        = {{297--311}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{Evolution & Development}},
  title        = {{von Willebrand factor D and EGF domains is an evolutionarily conserved and required feature of blastemas capable of multitissue appendage regeneration}},
  url          = {{https://lup.lub.lu.se/search/files/79042970/842948v2.full.pdf}},
  doi          = {{10.1111/ede.12332}},
  volume       = {{22}},
  year         = {{2020}},
}