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Evidence for postnatal neurogenesis in the human amygdala

Roeder, Sebastian S. ; Burkardt, Petra ; Rost, Fabian ; Rode, Julian ; Brusch, Lutz ; Coras, Roland ; Englund, Elisabet LU orcid ; Håkansson, Karl ; Possnert, Göran and Salehpour, Mehran , et al. (2022) In Communications Biology 5(1).
Abstract

The human amygdala is involved in processing of memory, decision-making, and emotional responses. Previous studies suggested that the amygdala may represent a neurogenic niche in mammals. By combining two distinct methodological approaches, lipofuscin quantification and 14C-based retrospective birth dating of neurons, along with mathematical modelling, we here explored whether postnatal neurogenesis exists in the human amygdala. We investigated post-mortem samples of twelve neurologically healthy subjects. The average rate of lipofuscin-negative neurons was 3.4%, representing a substantial proportion of cells substantially younger than the individual. Mass spectrometry analysis of genomic 14C-concentrations in... (More)

The human amygdala is involved in processing of memory, decision-making, and emotional responses. Previous studies suggested that the amygdala may represent a neurogenic niche in mammals. By combining two distinct methodological approaches, lipofuscin quantification and 14C-based retrospective birth dating of neurons, along with mathematical modelling, we here explored whether postnatal neurogenesis exists in the human amygdala. We investigated post-mortem samples of twelve neurologically healthy subjects. The average rate of lipofuscin-negative neurons was 3.4%, representing a substantial proportion of cells substantially younger than the individual. Mass spectrometry analysis of genomic 14C-concentrations in amygdala neurons compared with atmospheric 14C-levels provided evidence for postnatal neuronal exchange. Mathematical modelling identified a best-fitting scenario comprising of a quiescent and a renewing neuronal population with an overall renewal rate of >2.7% per year. In conclusion, we provide evidence for postnatal neurogenesis in the human amygdala with cell turnover rates comparable to the hippocampus.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Communications Biology
volume
5
issue
1
article number
366
publisher
Nature Publishing Group
external identifiers
  • pmid:35440676
  • scopus:85128378294
ISSN
2399-3642
DOI
10.1038/s42003-022-03299-8
language
English
LU publication?
yes
id
8425b6a8-6c2c-47fd-9e66-a77435a1acaa
date added to LUP
2022-06-20 16:18:08
date last changed
2025-04-16 05:11:03
@article{8425b6a8-6c2c-47fd-9e66-a77435a1acaa,
  abstract     = {{<p>The human amygdala is involved in processing of memory, decision-making, and emotional responses. Previous studies suggested that the amygdala may represent a neurogenic niche in mammals. By combining two distinct methodological approaches, lipofuscin quantification and <sup>14</sup>C-based retrospective birth dating of neurons, along with mathematical modelling, we here explored whether postnatal neurogenesis exists in the human amygdala. We investigated post-mortem samples of twelve neurologically healthy subjects. The average rate of lipofuscin-negative neurons was 3.4%, representing a substantial proportion of cells substantially younger than the individual. Mass spectrometry analysis of genomic <sup>14</sup>C-concentrations in amygdala neurons compared with atmospheric <sup>14</sup>C-levels provided evidence for postnatal neuronal exchange. Mathematical modelling identified a best-fitting scenario comprising of a quiescent and a renewing neuronal population with an overall renewal rate of &gt;2.7% per year. In conclusion, we provide evidence for postnatal neurogenesis in the human amygdala with cell turnover rates comparable to the hippocampus.</p>}},
  author       = {{Roeder, Sebastian S. and Burkardt, Petra and Rost, Fabian and Rode, Julian and Brusch, Lutz and Coras, Roland and Englund, Elisabet and Håkansson, Karl and Possnert, Göran and Salehpour, Mehran and Primetzhofer, Daniel and Csiba, László and Molnár, Sarolta and Méhes, Gábor and Tonchev, Anton B. and Schwab, Stefan and Bergmann, Olaf and Huttner, Hagen B.}},
  issn         = {{2399-3642}},
  language     = {{eng}},
  number       = {{1}},
  publisher    = {{Nature Publishing Group}},
  series       = {{Communications Biology}},
  title        = {{Evidence for postnatal neurogenesis in the human amygdala}},
  url          = {{http://dx.doi.org/10.1038/s42003-022-03299-8}},
  doi          = {{10.1038/s42003-022-03299-8}},
  volume       = {{5}},
  year         = {{2022}},
}