Steroid Conversion Using Immobilized Living Microorganisms
(1978) 4. p.317-322- Abstract
- In steroid transformations some of the advantages of immobilized
microorganisms seem to be especially important, since the manufacture of
steroid drugs often involves very expensive intermediates and products
(1). Therefore, we have been studying two corticosteroid
transformations. The first reaction is an 11-β-hydroxylation catalyzed
by free or polyacrylamide immobilized Curvularia lunata, producing cortisol from Reichstein’s S (cortexolon) (1, 2). The second reaction is a 3-ketosteroid-Δ1-dehydrogenation of cortisol to predniso’one catalyzed by free or polyacrylamide immobilized Anthnobacten simplex (3, 4).
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/85823136-be13-4d39-827b-4d6f24d1200c
- author
- Larsson, P.O. LU ; Ohlson, S. and Mosbach, K. LU
- organization
- publishing date
- 1978
- type
- Chapter in Book/Report/Conference proceeding
- publication status
- published
- subject
- host publication
- Enzyme Engineering
- editor
- Broun, Georges B. ; Manecke, Georg and Wingard, Lemuel B.
- volume
- 4
- pages
- 6 pages
- publisher
- Plenum Press
- ISBN
- 978-1-4684-6985-1
- 0-306-40021-9
- 978-1-4684-6987-5
- DOI
- 10.1007/978-1-4684-6985-1_63
- language
- English
- LU publication?
- yes
- id
- 85823136-be13-4d39-827b-4d6f24d1200c
- date added to LUP
- 2024-06-22 15:43:49
- date last changed
- 2024-09-13 10:50:27
@inbook{85823136-be13-4d39-827b-4d6f24d1200c, abstract = {{In steroid transformations some of the advantages of immobilized <br> microorganisms seem to be especially important, since the manufacture of<br> steroid drugs often involves very expensive intermediates and products <br> (1). Therefore, we have been studying two corticosteroid <br> transformations. The first reaction is an 11-β-hydroxylation catalyzed <br> by free or polyacrylamide immobilized <i>Curvularia lunata</i>, producing cortisol from Reichstein’s S (cortexolon) (1, 2). The second reaction is a 3-ketosteroid-Δ<sup>1</sup>-dehydrogenation of cortisol to predniso’one catalyzed by free or polyacrylamide immobilized <i>Anthnobacten simplex</i> (3, 4).}}, author = {{Larsson, P.O. and Ohlson, S. and Mosbach, K.}}, booktitle = {{Enzyme Engineering}}, editor = {{Broun, Georges B. and Manecke, Georg and Wingard, Lemuel B.}}, isbn = {{978-1-4684-6985-1}}, language = {{eng}}, pages = {{317--322}}, publisher = {{Plenum Press}}, title = {{Steroid Conversion Using Immobilized Living Microorganisms}}, url = {{http://dx.doi.org/10.1007/978-1-4684-6985-1_63}}, doi = {{10.1007/978-1-4684-6985-1_63}}, volume = {{4}}, year = {{1978}}, }