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Steroid Conversion Using Immobilized Living Microorganisms

Larsson, P.O. LU ; Ohlson, S. and Mosbach, K. LU (1978) 4. p.317-322
Abstract
In steroid transformations some of the advantages of immobilized
microorganisms seem to be especially important, since the manufacture of
steroid drugs often involves very expensive intermediates and products
(1). Therefore, we have been studying two corticosteroid
transformations. The first reaction is an 11-β-hydroxylation catalyzed
by free or polyacrylamide immobilized Curvularia lunata, producing cortisol from Reichstein’s S (cortexolon) (1, 2). The second reaction is a 3-ketosteroid-Δ1-dehydrogenation of cortisol to predniso’one catalyzed by free or polyacrylamide immobilized Anthnobacten simplex (3, 4).
Please use this url to cite or link to this publication:
author
; and
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
host publication
Enzyme Engineering
editor
Broun, Georges B. ; Manecke, Georg and Wingard, Lemuel B.
volume
4
pages
6 pages
publisher
Plenum Press
ISBN
978-1-4684-6985-1
0-306-40021-9
978-1-4684-6987-5
DOI
10.1007/978-1-4684-6985-1_63
language
English
LU publication?
yes
id
85823136-be13-4d39-827b-4d6f24d1200c
date added to LUP
2024-06-22 15:43:49
date last changed
2024-09-13 10:50:27
@inbook{85823136-be13-4d39-827b-4d6f24d1200c,
  abstract     = {{In steroid transformations some of the advantages of immobilized <br>
microorganisms seem to be especially important, since the manufacture of<br>
 steroid drugs often involves very expensive intermediates and products <br>
(1). Therefore, we have been studying two corticosteroid <br>
transformations. The first reaction is an 11-β-hydroxylation catalyzed <br>
by free or polyacrylamide immobilized <i>Curvularia lunata</i>, producing cortisol from Reichstein’s S (cortexolon) (1, 2). The second reaction is a 3-ketosteroid-Δ<sup>1</sup>-dehydrogenation of cortisol to predniso’one catalyzed by free or polyacrylamide immobilized <i>Anthnobacten simplex</i> (3, 4).}},
  author       = {{Larsson, P.O. and Ohlson, S. and Mosbach, K.}},
  booktitle    = {{Enzyme Engineering}},
  editor       = {{Broun, Georges B. and Manecke, Georg and Wingard, Lemuel B.}},
  isbn         = {{978-1-4684-6985-1}},
  language     = {{eng}},
  pages        = {{317--322}},
  publisher    = {{Plenum Press}},
  title        = {{Steroid Conversion Using Immobilized Living Microorganisms}},
  url          = {{http://dx.doi.org/10.1007/978-1-4684-6985-1_63}},
  doi          = {{10.1007/978-1-4684-6985-1_63}},
  volume       = {{4}},
  year         = {{1978}},
}